Differential Diagnostic Ultrasound Criteria of Papillary and Follicular Carcinomas: A Multivariate Analysis

Cordes, Michael; Kondrat, Pawel; Uder, Michael; Kuwert, Torsten; Sąsiadek, Marek

doi:10.1055/s-0034-1366282

Cited by 12 publications

(9 citation statements)

References 11 publications

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“…Liu et al 26 and Lai et al 27 drew the identical conclusion that lobulated or irregular margin was the significant feature on ultrasound for FTCs. Besides, we found that “taller than wide” in FTCs was rare (17.9% in our study and only 4–11% in the study of Cordes et al 11 ). By contrast, due to capsule confinement and relatively even tumor growth, FTA is generally round to oval with smooth margin.…”

Section: Discussionsupporting

confidence: 42%

“…[5][6][7] Moreover, ultrasonographic features of thyroid cancer have been reported, including solid, hypoechoic, irregular or micro-lobulated margin, taller than wide shape and microcalcifications with sensitivity of 26-87% and specificity of 53-93%, 8,9 but these ultrasonographic features are representative of papillary carcinomas. [10][11][12][13] Therefore, the purpose of our study is to explore the sonographic features of FTCs and the value of sonography in differentiating FTC from FTA.…”

Section: Introductionmentioning

confidence: 99%

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The Value of Sonography in Distinguishing Follicular Thyroid Carcinoma from Adenoma

Li¹,

Song²,

Lan³

et al. 2021

CMAR

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Purpose: Differentiation between follicular thyroid carcinomas (FTCs) and follicular thyroid adenomas (FTAs) is difficult and the sonographic features of FTC are not yet fully established. The purpose of this study is to explore the sonographic features of FTC and the value of sonography in differentiating FTCs from FTAs. Patients and Methods: A total of 28 pathologically proven FTCs and 53 FTAs in 78 patients who were performed thyroid surgery were included in this retrospective study. The sonographic features of each tumor including an interrupted halo, satellite nodule(s) with or without halo ring, local irregularity of margin and cluster of grapes sign were evaluated. A mode image of FTC halo was built up in our study. The frequencies of the sonographic features were compared by chi-square test or Fisher exact test between FTCs and FTAs. The relative risk of malignancy was assessed by logistic regression analysis. Results: Logistic regression analysis showed that a thick, irregular and/or interrupted halo with or without satellite nodule(s), hypoechoic or marked hypoechoic echogenicity, a predominantly solid pattern, cluster of grapes sign, micro-or macro-calcifications, rim calcifications correlated with significant increases in relative risk for FTCs (odds ratio 11.48 (1.37-96.56), 6.74 (1.05-43.30), 17.51 (1.78-172.53), 9.55 (1.44-63.46), 9.36 (1.25--70.15) and 17.45 (1.04-292.65), respectively, p<0.05). Two new sonographic features, an interrupted halo and satellite nodule(s) with or without halo ring, can only be found in FTCs. Conclusion:An interrupted halo and satellite nodule(s) with or without halo ring are specific sonographic features for FTCs. Sonography could play a role in differentiating follicular thyroid carcinoma from adenoma.

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Section: Discussionsupporting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

The Value of Sonography in Distinguishing Follicular Thyroid Carcinoma from Adenoma

Li¹,

Song²,

Lan³

et al. 2021

CMAR

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“…Further, although this study enrolled five pathological types of thyroid nodules, most of the malignant nodules were PTCs. However, the follicular thyroid carcinoma appears with different sonographic characteristics from PTC and tend to show more benign US features ( 22 , 23 ), which make it difficult for CAD systems to distinguish FTC from thyroid nodules. Large-scale multicenter studies are needed to overcome these drawbacks and generalize the findings.…”

Section: Discussionmentioning

confidence: 99%

A Clinical Assessment of an Ultrasound Computer-Aided Diagnosis System in Differentiating Thyroid Nodules With Radiologists of Different Diagnostic Experience

Zhang

Chen

et al. 2020

Front. Oncol.

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Introduction This study aimed to assess the diagnostic performance and the added value to radiologists of different levels of a computer-aided diagnosis (CAD) system for the detection of thyroid cancers. Methods 303 patients who underwent thyroidectomy from October 2018 to July 2019 were retrospectively reviewed. The diagnostic performance of the senior radiologist, the junior radiologist, and the CAD system were compared. The added value of the CAD system was assessed and subgroup analyses were performed according to the size of thyroid nodules. Results In total, 186 malignant thyroid nodules, and 179 benign thyroid nodules were included; 168 were papillary thyroid carcinoma (PTC), 7 were medullary thyroid carcinoma (MTC), 11 were follicular carcinoma (FTC), 127 were follicular adenoma (FA) and 52 were nodular goiters. The CAD system showed a comparable specificity as the senior radiologist (86.0% vs. 86.0%, p > 0.99), but a lower sensitivity and a lower area under the receiver operating characteristic (AUROC) curve (sensitivity: 71.5% vs. 95.2%, p < 0.001; AUROC: 0.788 vs. 0.906, p < 0.001). The CAD system improved the diagnostic sensitivities of both the senior and the junior radiologists (97.8% vs. 95.2%, p = 0.063; 88.2% vs. 75.3%, p < 0.001). Conclusion The use of the CAD system using artificial intelligence is a potential tool to distinguish malignant thyroid nodules and is preferable to serve as a second opinion for less experienced radiologists to improve their diagnosis performance.

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“…In the present case, the lesion exhibiting eggshell calcification also displayed punctiform blood flow signals, in agreement with previous findings by Lee and Rho ( 35 ). In previous studies, a lesion with characteristics of FC, including solid echogenicity, ill-defined margins, incomplete halo and macrocalcifications, was identified by US ( 32 , 35 , 38 , 39 ). In addition, the mass displayed a hyperechoic appearance, which is common in FC ( 27 , 37 ).…”

Section: Discussionmentioning

confidence: 99%

Primary follicular thyroid carcinoma metastasis to the kidney and widespread dissemination: A case report

et al. 2016

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Distant metastases are more common in follicular thyroid carcinoma (FC) than in papillary thyroid carcinoma. However, FC metastasis to the kidney with eggshell calcification, as observed in the present case, is rare. The current report presents a case of a 67-year-old woman exhibiting a solitary tumor in the mid pole of the left kidney. Radical nephrectomy was performed, as the tumor was diagnosed as a primary renal carcinoma using contrast-enhanced computed tomography. Once the tumor was confirmed to be FC, total thyroidectomy was performed. Following administration of an oral therapeutic dose of 100 mCi 131I, functional imaging demonstrated the presence of multifocal metastases in the chest and abdomen. Euthyrox® was prescribed orally to aid normal thyroid function. Follow-up 6 months later using radionuclide imaging demonstrated the disappearance of the multifocal metastases in the chest and abdomen. The distant metastasis of FC may represent the initial symptom of the primary lesion, which was neglected. Ultrasound is an effective method to examine nodules located on the thyroid.

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Differential Diagnostic Ultrasound Criteria of Papillary and Follicular Carcinomas: A Multivariate Analysis

Cited by 12 publications

References 11 publications

The Value of Sonography in Distinguishing Follicular Thyroid Carcinoma from Adenoma

The Value of Sonography in Distinguishing Follicular Thyroid Carcinoma from Adenoma

A Clinical Assessment of an Ultrasound Computer-Aided Diagnosis System in Differentiating Thyroid Nodules With Radiologists of Different Diagnostic Experience

Primary follicular thyroid carcinoma metastasis to the kidney and widespread dissemination: A case report

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