Different mechanisms of risperidone result in improved interpersonal trust, social engagement and cooperative behavior in patients with schizophrenia compared to trifluoperazine

Abstract

Aim: Atypical antipsychotic treatment (e.g. risperidone) has been found to improve social functioning more than standard antipsychotic treatment. However, it is unclear which specific social behaviors are implicated in this improvement. The current study employed an interactive puzzle game to examine how social behaviors contribute to the improvement of social functioning by comparing patients receiving risperidone with those receiving trifluoperazine.Methods: Scores on the Positive and Negative Syndrome Scale, executive functioning, and social functioning were obtained from 24 patients with schizophrenia receiving either risperidone (n = 12) or trifluoperazine (n = 12), before their social behavior was measured in the interactive Tangrams Game. Immediately after the Tangrams Game, participants filled in two questionnaires measuring their interpersonal trust and rejection toward their game partner.Results: Patients receiving risperidone showed more social engagement, cooperative behavior and interpersonal trust toward their game partners than those receiving trifluoperazine. Additional multivariate analysis of variance revealed that lower affiliative behavior was a function of positive symptoms; interpersonal trust had an impact on social engagement but executive functioning did not explain lower interpersonal trust or social disengagement.Conclusion: Improvement of social competence by risperidone might be related to the enhancement of both social behaviors and interpersonal trust as well as better symptom resolution.

Interpersonal risk communication matters more than media risk communication in its impact on individuals’ trust and preventive behaviors during COVID-19

“…Therefore, interpersonal trust is conceived of as a distal factor that can affect individuals' behavioral responses to a risky situation. A number of studies have focused on the development of interpersonal trust and its impact on individuals' behavioral intentions such as social engagement, risk reduction behaviors, organizational citizenship behavior, job satisfaction, innovative behaviors, prosocial behaviors (i.e, knowledge sharing), greater patients' knowledge, and adherence to treatment plans [ 52 , 58 , 63 ]. However, there is a lack of research that explores the impact of interpersonal trust on individuals’ preventive behaviors, especially during the COVID-19.…”

Psychopathological profile and antipsychotic treatment may be linked to internalised stigma in schizophrenia – a cross-sectional study

“…Risperidone is a member of the second-generation group of antipsychotic drugs, which is currently recognised as first choice in schizophrenia treatment due to its relative safety and efficacy [30]. Although no previous data exists on the link between the use of risperidone and internalised stigma, data from one randomised controlled trial suggests that risperidone may improve social engagement, cooperative behaviour and the interpersonal trust of patients with schizophrenia, which may prevent the patient experiencing a sense of alienation [31].…”