Differences in the ability of cells to fuse are mediated by strains of epstein‐barr virus

Abstract

Epstein-Barr virus (EBV) preparations from both NPC-KT cells (NPC-EBV) and P3HR-1 cells (HR-1-EBV) can induce cell fusion between EBV receptor (EBVR)-positive Raji cells and EBVR-negative cells, but other strains of EBV cannot induce cell fusion. The effect of these two EBV isolates on ability of cells to fuse has been studied to determine if there are differences in the biological properties of the different EBV isolates, particularly the isolates obtained from nasopharyngeal carcinoma such as NPC-EBV. The frequency of cell fusion between NPC-EBV-superinfected Raji cells and EBVR-negative epithelial cells (Ad-AH) was increased more than 30-fold in the presence of medium containing 1% dimethylsulfoxide (DMSO). However, the frequency of cell fusion between HR-1-EBV-superinfected Raji cells and Ad-AH cells was unaffected under the same conditions. The data show that differences in the ability of cells to fuse are induced by variants of EBV in response to DMSO. These differences may be important in elucidating the different biological properties of EBV isolates and might have implications for the pathophysiology of EBV-associated illness.

Primary Description of a New Entity, Renal Cell–Like Carcinoma of the Nasal Cavity

“…11 The nasal tumor was the initial presentation for up to 20% of these cases 11 and in subsequent reports. [12][13][14][15][16][17][18][19][20] A synchronous renal primary tumor was confirmed in all of these cases.…”

Unusual Metastases of Renal Cell Carcinoma

“…We have found one single case in the literature [8], We believe that the oral cavity métastasés were inci sional métastasés. This patient is still alive 10 years after the initial diagnosis despite métastases at various body sites.…”

Case Report Metastatic renal cell carcinoma to the left maxillary sinus

“…Even though many metastatic tumors originating from renal cancer develop in multiples, most metastatic tumors in the nasal or paranasal sinuses are single and treated surgically (Matsumoto and Yanagihara, 1982). Patients with a single resectable metastatic lesion should be treated aggressively, since they have an excellent chance for extended survival before further progression of this disease.…”