Primary Description of a New Entity, Renal Cell–Like Carcinoma of the Nasal Cavity

Zur, Karen B.; Brandwein, Margaret; Wang, Beverly; Som, Peter M.; Gordon, Ronald E.; Urken, Mark L.

doi:10.1001/archotol.128.4.441

Cited by 48 publications

(56 citation statements)

References 26 publications

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“…Both vimentin, which stains the intermediate filaments of tissues of mesenchymal origin, and Pax-8, a marker of mullerian, renal and thyroid tissue, are not expressed in SNRLCA [13]. While the cell of origin of SNRLCA is not established, [7,8,10, 11] DOG-1 and SOX-10 expression confirm the seromucinous phenotype of SNRLCA. Even based on the earlier cases, a seromucinous phenotype was implied given the frequent S100 immunoreactivity, and carbonic anhydrase expression typical of Scheiderian seromucinous glands [10].…”

Section: Discussionmentioning

confidence: 89%

“…SNRCLA is a relatively new entity that was first described in in 2002 when Zur et al described a patient with a sinonasal clear cell carcinoma resembling renal cell carcinoma in the absence of any underlying primary renal tumor [7]. Since that initial description, additional reports have surfaced and currently there are 13 patients described in the Negative Pax-8 staining (f).…”

Section: Discussionmentioning

confidence: 99%

“…Endoscopically, this tumor has been described in most articles to be a red, polypoid appearing mass. Tumor subsites have included the following: nasal cavity (N = 9), paranasal sinuses (N = 2), nasopharynx (N = 2) [7][8][9][10]. This case is unique in that it occurred 8 years after radiation therapy for a contralateral "acinic cell carcinoma."…”

Section: Discussionmentioning

confidence: 99%

“…The tumor can be organized in solid, nodular, or follicular forms with rare mitotic activity. Extension invasion and necrosis are not typically seen [7,8,11,12].…”

Section: Discussionmentioning

confidence: 99%

“…The aforementioned seromucinous phenotype raises consideration for named salivary clear cell tumors [7,8]. A major diagnostic challenge given the SOX-10 and DOG-1 immunoreactivity will be in distinguishing the lesion from acinic cell carcinoma.…”

Section: Primary (Named) Salivary Clear Cell Lesionsmentioning

confidence: 99%

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Sinonasal Renal Cell-Like Carcinoma: Case Report and Review of the Literature

Kubik

Barasch

Choby

et al. 2016

Head and Neck Pathol

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recent WHO classification of primary sinonasal malignancies contains 44 distinct histopathologic entities [3]. Understandably, these cancers present a formidable challenge for both the surgeon and pathologist.In this article we present an unusual case of clear cell neoplasia of the paranasal sinuses found to be consistent with sinonasal renal cell-like adenocarcinoma (SNRCLA). The finding of clear cell neoplasia in a sinonasal specimen is rare but associated with a surprisingly wide differential diagnosis. When evaluating the differential diagnosis for a clear cell neoplasm of the sinonasal tract, an underlying renal cell carcinoma (RCC) must first be ruled out. RCC is the most common metastatic lesion to the nasal cavity and paranasal sinuses [4] and approximately 6-15% of patients with RCC will have metastatic deposits in the head and neck [5,6]. In addition to metastatic RCC, other diagnostic considerations for clear cell neoplasia in the paranasal sinuses include a clear cell variant of squamous cell carcinoma, melanoma, primary salivary clear cell carcinoma, metastatic clear cell thyroid carcinoma, clear cell predominant mucoepidermoid carcinoma, and SNRCLA. Case ReportAn 80 year old female presented to our otolaryngology clinic with an asymptomatic right sinonasal mass. She reported a history of left sided acinic cell carcinoma treated at an outside institution with endonasal resection and adjuvant radiotherapy approximately eight years prior. Diagnostic nasal endoscopy revealed a large friable soft tissue mass arising from the lateral nasal wall near the axilla of the right middle turbinate. Imaging revealed a 3 cm tumor centered at the right nasolacrimal sac with extension superiorly to involve the nasal septum and dura of the anterior Abstract The differential diagnosis for clear cell neoplasms of the sinonasal tract is wide but critical to understand. In this paper, we describe a case of renal cell-like adenocarcinoma (SNRCLA) presenting as a paranasal sinus mass with clear cell morphology. The relevant literature is reviewed and the workup for clear cell neoplasms described. SNRCLA is a rarely encountered low grade glandular malignancy of the paranasal sinuses. Despite its morphologic mimicry of renal cell carcinoma, SNRCLA demonstrates a seromucinous phenotype and is associated with a favorable prognosis and low recurrence rates after surgical resection.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The tumor can be organized in solid, nodular, or follicular forms with rare mitotic activity. Extension invasion and necrosis are not typically seen [7,8,11,12].…”

Section: Discussionmentioning

confidence: 99%

Section: Primary (Named) Salivary Clear Cell Lesionsmentioning

confidence: 99%

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