Differences in Peptic Ulcer Between the East and the West

Leong, Rupert W.

doi:10.1016/j.gtc.2009.03.010

Cited by 33 publications

(23 citation statements)

References 82 publications

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“…A recent study conducted in São Paulo, Brazil, reported high prevalence of duodenal ulcer related to H. pylori infection (12) . This study did not assess the use of NSAID and could be also reflecting different type of Brazilian population (11) because in Rio Grande do Sul, the most southern Brazilian state, was observed a decrease of duodenal ulcer prevalence along 10 years. This study did not approach H. pylori status or NSAID intake (21) .…”

Section: Discussionmentioning

confidence: 98%

Peptic Ulcer Frequency Differences Related to H. Pylori or Aines

Carli

Pires

Rohde

et al. 2015

Arq. Gastroenterol.

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-Background -Peptic ulcer etiology has been changing because of H. pylori decline. Objective -To estimate peptic ulcer prevalence in 10 years-interval and compare the association with H. pylori and use of non-steroidal anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs use was 3.5% in A and 13.3% in B. Neither condition occurred in 10.4% and 20.5% in A and B respectively. Comparing both periods, we observed reduction of peptic ulcer associated to H. pylori (P=0.000), increase of peptic ulcer related to non-steroidal anti-inflammatory drugs (P=0.000) and idiopathic peptic ulcer (P=0.002). The concurrent association of H. pylori and non-steroidal anti-inflammatory drugs was also higher in B (P=0.002). Rates of gastric ulcer were higher and duodenal ulcer lower in the second period. Conclusions -After 10 years, the prevalence of peptic ulcer decreased, as well as ulcers related to H. pylori whereas ulcers associated to non-steroidal anti-inflammatory drugs increased.There was an inversion in the pattern of gastric and duodenal ulcer and a rise of idiopathic peptic ulcer. HEADINGS -Peptic ulcer. Helicobacter pylori. Non-steroidal anti-inflammatory agents. Stomach ulcer. Duodenal ulcer.

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Section: Discussionmentioning

confidence: 98%

Peptic Ulcer Frequency Differences Related to H. Pylori or Aines

Carli

Pires

Rohde

et al. 2015

Arq. Gastroenterol.

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“…31 Compared with the West, Hong Kong has a higher prevalence of peptic ulcer disease. [38][39][40] Therefore, it is possible that clinicians in Hong Kong have a higher tendency to prescribe gastroprotective agents compared with other countries. Furthermore, medications in HA are highly subsidized (85% to 98%) by the government.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study

et al. 2015

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“…Secondly, discordant results may be due to the geographic distribution variations of Helicobacter species. Epidemiologically, The prevalence of H. Pylori in East Asian countries is significantly higher than in western countries [12]. Investigators from Taiwan obtained DNA fragments of Helicobacter sp.…”

Section: Introductionmentioning

confidence: 99%

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

et al. 2011

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BackgroundSince the isolation of Helicobacter species in biliary system, a hypothetical question was raised about the role of these agents in the development of cholelithiasis. This meta-analysis is to explore the association between the Helicobacter infection and biliary lithiasis.Methodology/Principal FindingsA systematic literature search was performed to identify all eligible articles. Meta-analysis which was carried out using odds ratio and random effect model, 95% confidence intervals for odds ratio was calculated. Quantitative assessment of heterogeneity was explored by chi-square test with significance set at P value 0.10 and was measured using I 2 statistic. Eighteen studies published between 1998 and 2011 were finally eligible for meta-analysis. H. Pylori, H. Bilis, H. Hepaticus, H. Pullorum and H. Ganmani were studied. With heterogeneity (I2 = 69.5%, P<0.0001), significantly higher pooled infection rates of H. Pylori (OR: 2.59, 35.82% versus 26.75%, P = 0.01) and H. Hepaticus (OR: 3.13, 31.30% versus 12.12%, P = 0.02) were observed in lithiasis group. Higher prevalence of H. Pylori in cholelithiasis patients were reported by studies from East Asia, South Asia and South America. Evidences supporting the higher presence of H. Pylori in cholelithiasis patients could be found by PCR for detecting 16s rRNA in bile, 26kDa protein gene in biliary tissue and immunohistochemistry. Using multiple detection tests could increase the detection rate of H. Pylori.Conclusions/SignificancesOur meta-analysis suggests a trend of higher presence of H. Pylori in cholelithiasis patients than control group and this trend was significant in the regions with higher prevalence of this agent. Evidences supporting the association between Helicobacter and cholelithiasis could be found by using different tests but the gold standard for the identification of these bacteria in biliary system has yet to be established. Considering obvious heterogeneity, a large multi-center study will facilitate us to further clarify the association between the Helicobacter infection and cholelithiasis.

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Differences in Peptic Ulcer Between the East and the West

Cited by 33 publications

References 82 publications

Peptic Ulcer Frequency Differences Related to H. Pylori or Aines

Peptic Ulcer Frequency Differences Related to H. Pylori or Aines

Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study

Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

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