Peptic Ulcer Frequency Differences Related to H. Pylori or Aines

Carli, Diego Michelon De; Pires, Rafael Cardoso; Rohde, S; Kavalco, Caroline Mayara; Fagundes, Renato Borges

doi:10.1590/s0004-28032015000100010

Cited by 11 publications

(11 citation statements)

References 24 publications

(40 reference statements)

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“…Our results confirmed those of other African authors including Millogo [6], Lawson [8], Diarra [7], and Diouf [11] with respectively 43.4, 43.56 years, 43.28 years and 42.5 years. The PUD occurs at a later age in the European than in African one [8].…”

Section: Demographic Aspectssupporting

confidence: 91%

Peptic Ulcer Disease in CHUYO

Coulibaly¹,

Sermé²,

Godonou³

et al. 2016

OJGas

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Background: Prevalence of Peptic Ulcer Disease (PUD) is decreasing in developed countries since the use of the treatments for eradication of Helicobacter pylori. Objectives: To revalue the sociodemographic, clinical and evolutionary aspects of the PUD among hospitalized patients in CHUYO. Methodology: This prospective study is related to 65 files of patients hospitalized in hepato-gastroenterology and general surgical services of the CHUYO between March 1st and August 31st, 2015. Results: Hospital utilization rate was 6.59%. The average age of patients was 40.6 years with extremes of 17 and 80 years. The sex ratio was 9.8. The location of the ulcer was 69.23% in stomach. A notion of taking aggressive gastrointestinal products was found in 62 patients (95.4%). The clinical picture was represented by diffuse abdominal pain (76.92%), peritoneal irritation syndrome (64.61%) and epigastric pain (56.92%), anemia (23.07%). Gastric perforations (64.61%) and gastrointestinal bleeding (12.30%) were the main complications. Consumption of non-steroidal anti-inflammatory drugs (NSAIDs) was found in 81.5% of cases. The management was medical and/or surgical with an overall mortality rate of 7.7%. Conclusion: The PUD rate decreased from 10.12% to 6.59% in 5 years. The complications are dominated by stomach perforations. They are relative increase and seem related to NSAIDs. Better management of this disease requires awareness of the population to selfmedication.

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“…Because HP is the most common infection in humans, and as a consequence of its chronic character, may trigger serious diseases with considerable morbidity 1 , 3 , 4 , 5 , 8 , 13 , 19 , 20 , 30 . Comparative study of its prevalence in distinct regions over the years is of great importance to analyze if the health improvement of population translate into reducing the prevalence, as well as guiding strategies and guidelines for the prevention and specific treatment for each area proportional to the degree of socioeconomic and cultural development 2 , 7 , 11 , 12 , 14 , 20 , 26 , 28 , 29 .…”

Section: Discussionmentioning

confidence: 99%

“…The recommendation of the American College of Gastroenterology in 2007 is to realize HP urease test in patients with dyspepsia, active ulcer or history of ulcer, lymphomas, in chronic use of proton pump inhibitors and steroid anti-inflammatories 3 ; in anemic patients with vitamin B12 and iron deficiency; and asymptomatic patients with a family history of gastric cancer or in families with HP treatment 4 , 9 , 10 , 23 , 24 , 29 . In Brazil, the III HP Brazilian Consensus in 2012, had as one of the goals disclose and guide dietetic and hygiene measures to the population, develop strategies with the Ministry of Health to improve sanitation and water reservoirs and guide health professionals regarding HP prevention , diagnosis and treatment 2 , 3 , 4 , 6 , 9 , 11 , 12 , 14 , 25 , 30 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Helicobacter Pylori Ten Years Ago Compared to the Current Prevalence in Patients Undergoing Upper Endoscopy

Frugis

Czeczko

Malafaia

et al. 2016

ABCD, arq. bras. cir. dig.

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Background: Helicobacter pylori has been extensively studied since 1982 it is estimated that 50% of the world population is affected. The literature lacks studies that show the change of its prevalence in the same population over time. Aim: To compare the prevalence of H. pylori in 10 years interval in a population that was submitted to upper endoscopy in the same endoscopy service. Method: Observational, retrospective and cross-sectional study comparing the prevalence of H. pylori in two samples with 10 years apart (2004 and 2014) who underwent endoscopy with biopsy and urease. Patients were studied in three consecutive months of 2004, compared to three consecutive months of 2014. The total number of patients was 2536, and 1406 in 2004 and 1130 in 2014. Results: There were positive for H. pylori in 17 % of the sample as a whole. There was a significant decrease in the prevalence from 19.3% in 2004 to 14.1% in 2014 (p<0.005). Conclusion: There was a 5.2% reduction in the prevalence of H. pylori comparing two periods of three consecutive months with 10 years apart in two equivalent population samples.

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“…Nonetheless, bleeding risk associated with aspirin therapy was attenuated to nonsignificant after additionally adjusting for HP infection. As is well known that HP infection increases the incidence of gastric and duodenal ulceration [ 19 , 20 ], and the prevalence of HP infection in China is much higher than the other developed countries [ 21 ]. Therefore, it was conceivable that subjects with HP infection in our current study might have occult gastrointestinal ulceration which exposed them at higher risk of gastrointestinal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Effects of low-dose aspirin in subjects with dyslipidemia

Lou

Chen

Xia³

2016

Lipids Health Dis

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BackgroundTo evaluate the efficacy and safety of aspirin usage for coronary heart disease (CHD) primary prevention in patients with dyslipidemia.MethodsA cross-sectional study was conducted to enrolled subjects with documented dyslipidemia. A total of 202 patients with dyslipidemia were recruited and 138 were undergone aspirin treatment before this indexed admission and 64 had never been treated with aspirin. All subjects were undergone coronary angiography to diagnoses CHD. Clinical characteristics were collected and comparisons were performed between subjects with aspirin and subjects without aspirin therapy. Logistic regression analysis was conducted to assess the relation between aspirin and incident CHD and bleeding events.ResultsCompared to those with aspirin therapy, CHD incidence was significantly higher in subjects without aspirin therapy (23.4 % versus 18.1 %, P < 0.05). Five patients in the aspirin group had gastrointestinal bleeding and no bleeding event was occurred in subjects without aspirin therapy. Subjects with aspirin therapy had higher rate of previous helicobacter pylori (HP) infection (8.7 % versus 4.7 %, P < 0.05). Compared to subjects without CHD, subjects with CHD were older, had higher frequencies of males and smokers, had higher heart rate, serum LDL cholesterol, Lp(a) and Hs-CRP levels. Percentages of subjects with hypertension, diabetes, gastrointestinal bleeding, and HP infection were also considerably higher in CHD group (P < 0.05 for all comparison). Logistic regression analysis revealed that aspirin was associated with reduced incidence of CHD, with odds ratio (OR) of 0.85 (95 % confidence interval (CI): 0.80-0.94, P < 0.05). Regarding safety endpoint, gastrointestinal bleeding risk associated with aspirin was attenuated to nonsignificant after adjusting for HP infection, with OR of 1.16 (95 % CI: 0.99-1.52, P = 0.178).ConclusionAspirin is beneficial for reducing incident CHD, while modestly increases gastrointestinal bleeding risk. Screening subjects with previous HP infection may avoid aspirin-related gastrointestinal bleeding.

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“…Работы 1980-х и 1990-х годов показывали, что при язве двенадцатиперстной кишки и в 70 % случаев при язве желудка распространенность инфекции H. pylori составляет 90 % [13]. Однако эпидемиологические исследования последних 20-30 лет отразили тенденцию к резкому снижению заболеваемости, темпов госпитализации и смертности от H. pylori-ассоциированной патологии, что, по-видимому, можно связать с постоянным улучшением социально-экономических и гигиенических условий, появлением современных антисекреторных препаратов, а также с широким внедрением в клиническую практику эрадикационной терапии [14,15].…”

Section: рис 2 гастритоподобный вариант неходжкинской лимфомы желудunclassified

MALT lymphoma and erosive and ulcerative lesions of the stomach: modern diagnostic approaches and own clinical observation

et al. 2019

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Due to the pronounced polymorphism of stomach MALT-lymphoma endoscopic manifestations, often mimicking inflammatory changes of various etiologies, difficulties arise in the timely diagnosis of this disease. The alertness of the endoscopist and the use of integrated approaches to endoscopic diagnosis, taking into account the existing criteria for differential diagnosis, will undoubtedly improve the results of treatment.

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Peptic Ulcer Frequency Differences Related to H. Pylori or Aines

Cited by 11 publications

References 24 publications

Peptic Ulcer Disease in CHUYO

Prevalence of Helicobacter Pylori Ten Years Ago Compared to the Current Prevalence in Patients Undergoing Upper Endoscopy

Effects of low-dose aspirin in subjects with dyslipidemia

MALT lymphoma and erosive and ulcerative lesions of the stomach: modern diagnostic approaches and own clinical observation

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