Differences in cytotoxicity between 5% tetracycline hydrochloride and 15% EDTA as root canal irrigant

Juniarti, Devi Eka; Samadi, Karlina; Sudirman, Achmad

doi:10.20473/j.djmkg.v41.i2.p67-69

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…The stability in water and the higher hydrophilicity of zein fibers with PEO in the shell, required for a potential application of these fiber mats in wound healing, facilitated cell attachment and migration, not only on the surface of the fiber mats, but also within the pores of the mats (Figure 7). However, this depended on either the changed morphology of the fibers (Figure 7) or the presence of T in the fibers [65], or a combination of both. Most often, cells are unable to penetrate into fiber mats due to the dense structure of the mats and small pore size, resulting in cell migration only on the surface of the mat.…”

Section: Discussionmentioning

confidence: 99%

Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

et al. 2020

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The development of biomaterials for wound healing applications requires providing a number of properties, such as antimicrobial action, facilitation of cell proliferation, biocompatibility and biodegradability. The aim of the present study was to investigate morphological and mechanical properties of zein-based microfibers, ultimately aimed at creating an environment suitable for wound healing. This was achieved through co-axial electrospinning of core–shell microfibers, with zein protein in the core and polyethylene oxide (PEO) in the shell. Small amounts of PEO or stearic acid were additionally incorporated into the fiber core to modify the morphology and mechanical properties of zein fibers. The presence of PEO in the core was found to be essential for the formation of tubular fibers, whereas PEO in the shell enhanced the stability of the microfibers in water and ensured high elasticity of the microfiber mats. Tetracycline hydrochloride was present in an amorphous form within the fibers, and displayed a burst release as a result of pore-formation in the fibers. The developed systems exhibited antimicrobial activity against Staphylococcus aureus and Escherichia coli, and showed no cytotoxic effect on fibroblasts. Biocompatibility, antimicrobial activity and favorable morphological and mechanical properties make the developed zein-based microfibers a potential biomaterial for wound healing purposes.

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Section: Discussionmentioning

confidence: 99%

Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

et al. 2020

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“…Sifat ini akan membersihkan smear layer karena kemampuannya dalam membentuk ikatan kompleks (chelate) dengan kandungan kalsium yang terdapat pada smear layer. 17 Sebagai larutan irigasi, asam sitrat memiliki kemampuan membuang smear layer terutama debris anorganik untuk membersihkan dinding dentin. 18,19 Sesuai dengan penelitian yang telah dilakukan oleh peneliti, pada kavitas yang diulas dengan asam sitrat 6%, dihasilkan kavitas yang tidak sepenuhnya bersih.…”

Section: Penelitianunclassified

Perbedaan daya pembersih kavitas saponin ekstrak kulit manggis (Garcinia mangostana Linn) 0,78% dan asam sitrat 6% (The difference of 0,78% saponin from mangosteen pericarp extract and 6% citric acid for cleanliness of cavity)

Setianingrum

Suardita

Subiyanto

et al. 2019

CDJ

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Background: Cleanliness of cavity is considered important for a restoration. Smear layer formed after cavity preparation should be removed in order not to disrupt the bond adhesion between restorative materials and dental cavities. Saponins contained in mangosteen pericarp (Garcinia mangostana L.) have surfactant properties that can eliminate the smear layer assessed. 6% citric acid is a chelating agent which can eliminate the inorganic particles of the smear layer. Until now, the research on the differences of 0,78% saponin from mangosteen pericarp extract and 6% citric acid for cleanliness of cavity has never been done. Purpose: To see the differences between 0,78% saponin from mangosteen pericarp extract and 6% citric acid as cavity cleanser. Method: Eighteen human teeth with complete crown, no caries, and no fractures were randomized in 3 groups (n≥6), in this experiment use (n=6). The cavity was prepared using wheels bur for hand use instrument. After instrumentation, each cavity on the first group used 0,78% saponin from mangosteen pericarp extract as cavity cleanser, the second group used 6% citric acid as cavity cleanser, and the control group used aquadest. Then, the teeth were split to be observed on Scanning Electron Microscope (SEM). Result: For Mann- Whitney test there were significant differences just between 078% saponin from mangosteen pericarp extract with 6% citric acid, and 6% citric acid with aquadest, but not for 0,78% saponin from mangosteen pericarp extract with aquadest. Median value of 6% citric acid showed 2,000 which is the smallest value compared to the value of the other groups. Conclusion: The cleanliness of cavity with 6% citric acid is better than that with 0,78% saponin from mangosteen pericarp extract.

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Differences in cytotoxicity between 5% tetracycline hydrochloride and 15% EDTA as root canal irrigant

Cited by 2 publications

References 6 publications

Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

Perbedaan daya pembersih kavitas saponin ekstrak kulit manggis (Garcinia mangostana Linn) 0,78% dan asam sitrat 6% (The difference of 0,78% saponin from mangosteen pericarp extract and 6% citric acid for cleanliness of cavity)

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