Differences in Brain Function Between Relapsing and Abstaining Alcohol-Dependent Patients, Evaluated by Eeg Mapping

Saletu-Zyhlarz, Gerda; Arnold, Oliver; Anderer, P.; Oberndorfer, S; Walter, Henriëtte; Lesch, Otto-Michael; Böning, Jobst; Saletu, B.

doi:10.1093/alcalc/agh041

Cited by 85 publications

(105 citation statements)

References 54 publications

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“…Using the resting EEG for diagnostic and preventive purposes, therefore, makes sense. Moreover, EEGs may also be of prognostic value, as EEG patterns in patients who relapse differ from those in patients who continue to abstain [147]. In summary, as slow theta activity is believed to be inhibitory, alpha activity to reflect normal brain functioning, and fast beta activity to be excitatory, the low-voltage fast desynchronized patterns described in alcoholics may reflect hyperarousal of the CNS.…”

Section: Beta Bandmentioning

confidence: 99%

Chronic alcoholism: Insights from neurophysiology

Campanella¹,

Petit²,

Maurage³

et al. 2009

Neurophysiologie Clinique/Clinical Neurophysiology

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SummaryIntroduction. -Increasing knowledge of the anatomical structures and cellular processes underlying psychiatric disorders may help bridge the gap between clinical signs and basic physiological processes. Accordingly, considerable insight has been gained in recent years into a common psychiatric condition, i.e., chronic alcoholism. Material and methods. -We reviewed various physiological parameters that are altered in chronic alcoholic patients compared to healthy individuals -continuous electroencephalogram, oculomotor measures, cognitive event-related potentials and event-related oscillations -to identify links between these physiological parameters, altered cognitive processes and specific clinical symptoms. Results. -Alcoholic patients display: (1) high beta and theta power in the resting electroencephalogram, suggesting hyperarousal of their central nervous system; (2) abnormalities in smooth pursuit eye movements, in saccadic inhibition during antisaccade tasks, and in prepulse inhibition, suggesting disturbed attention modulation and abnormal patterns of prefrontal activation that may stem from the same prefrontal ''inhibitory'' cortical dysfunction; (3) decreased amplitude for cognitive event-related potentials situated along the continuum of informationprocessing, suggesting that alcoholism is associated with neurophysiological deficits at the level of the sensory cortex and not only disturbances involving associative cortices and limbic structures; and (4) decreased theta, gamma and delta oscillations, suggesting cognitive disinhibition at a functional level. Discussion. -The heterogeneity of alcoholic disorders in terms of symptomatology, course and outcome is the result of various pathophysiological processes that physiological parameters * Corresponding author. E-mail address: salvatore.campanella@chu-brugmann.be (S. Campanella).

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Section: Beta Bandmentioning

confidence: 99%

Chronic alcoholism: Insights from neurophysiology

Campanella¹,

Petit²,

Maurage³

et al. 2009

Neurophysiologie Clinique/Clinical Neurophysiology

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“…As slow activities are considered to be inhibitory, alpha activity may be viewed as an expression of normal brain functioning and fast beta activities as excitatory, the lowvoltage fast desynchronized patterns may be interpreted as hyperarousal of the central nervous system (CNS) (Saletu-Zyhlarz et al, 2004). The investigations by Bauer (2001b) and Winterer et al (1998) showed a worse prognosis for the patient group with a more 8 JOURNAL OF NEUROTHERAPY pronounced frontal CNS hyperarousal.…”

Section: Qeeg In Sudmentioning

confidence: 99%

“…It may be hypothesized that these hyperaroused relapsing patients require more CNS sedation than abstaining ones. EEG maps of alcohol-dependent patients differ significantly from those of normal controls and patients suffering from other mental disorders and might be useful for diagnostic purposes (Pollock, Schneider, Zemansky, Gleason, & Pawluczyk, 1992;Saletu et al, 2002;Saletu-Zyhlarz et al, 2004). Decreased power in slow bands in alcoholic patients may be an indicator of brain atrophy and chronic brain damage, whereas an increase in the beta band may be related to various factors such as medication use, family history of alcoholism, and=or hallucinations, suggesting a state of cortical hyperexcitability (CoutinChurchman, Moreno, Añ nez, & Vergara, 2006).…”

Section: Qeeg In Sudmentioning

confidence: 99%

“…Alcohol-dependent individuals have different synchronization of brain activity than light drinkers as reflected by differences in resting EEG coherence (Kaplan, Glueck, Hesselbrock, & Reed, 1985;Michael, Mirza, Mukundan, & Channabasavanna, 1993;Winterer, Enoch, et al, 2003) and power (e.g., Bauer, 2001aBauer, , 2001bEnoch, White, Harris, Rohrbaugh, & Goldman, 2002;Rangaswamy et al, 2002;Saletu-Zyhlarz et al, 2004). Most differences in EEG coherence and power are found in the alpha and beta bands.…”

Section: Qeeg In Sudmentioning

confidence: 99%

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EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy and Recommendations for Further Research

Sokhadze¹,

Cannon²,

Trudeau³

2008

Journal of Neurotherapy

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“…Alcohol-dependent individuals have different synchronization of brain activity than light drinkers as reflected by differences in resting EEG coherence (Kaplan et al, 1985;Michael et al, 1993;Winterer et al, 2003a) and power (e.g., Bauer, 2001;Enoch et al, 2002;Rangaswamy et al, 2002;Saletu-Zyhlarz et al, 2004). Most differences in EEG coherence and power are found at alpha (8-12 Hz), slowbeta (12 -20 Hz), and fast-beta (20 -30 Hz) frequencies.…”

Section: Introductionmentioning

confidence: 99%

Moderate-to-heavy alcohol intake is associated with differences in synchronization of brain activity during rest and mental rehearsal

Bruin

Stam

Bijl

et al. 2006

International Journal of Psychophysiology

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In alcohol-dependent individuals, synchronization of brain activity is different from that in non-alcohol-dependent individuals as reflected by EEG differences at alpha and beta frequencies . These EEG differences may not only be related to long-term alcohol intake but also to genetic factors that are associated with alcohol dependence. Thus, it is not known what the pure effect of long-term alcohol intake on synchronization of brain activity is. Therefore, we investigated whether EEG synchronization differs between light (0.5 -6 drinks per week), moderate (7 -20 drinks per week), and heavy (21 -53 drinks per week) drinkers. All participants (49 males and 47 females) were free of a personal and family history of alcohol dependence. Eyes-closed EEG was recorded at rest and during mental rehearsal of pictures. EEG synchronization was determined by computing Synchronization Likelihood for six frequency bands (0.5 -4 Hz, 4 -8 Hz, [8][9][10][11][12][12][13][14][15][16][17][18][19][20][20][21][22][23][24][25][26][27][28][29][30][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. Both male and female heavy drinkers displayed a loss of lateralization in alpha (8 -12 Hz) and slow-beta (12 -20 Hz) synchronization. In addition, moderately and heavily drinking males had lower fast-beta (20 -30 Hz) synchronization than lightly drinking males. It is concluded that both male and female drinkers who drink 21 alcoholic drinks per week or more have impaired synchronization of brain activity during rest and mental rehearsal at alpha and beta frequencies as compared to individuals who drink less. As individuals with a personal or family history of alcohol dependence were excluded, the confounding effects of genetic factors related to alcohol dependence on synchronization of brain activity were minimized. D

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Differences in Brain Function Between Relapsing and Abstaining Alcohol-Dependent Patients, Evaluated by Eeg Mapping

Cited by 85 publications

References 54 publications

Chronic alcoholism: Insights from neurophysiology

Chronic alcoholism: Insights from neurophysiology

EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy and Recommendations for Further Research

Moderate-to-heavy alcohol intake is associated with differences in synchronization of brain activity during rest and mental rehearsal

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