Difference in the effect of adiposity on bone density between pre- and postmenopausal women

Douchi, Tsutomu; Yamamoto, Shinako; Oki, Toshimichi; Maruta, Kuninori; Kuwahata, Riki; Yamasaki, Hedeki; Nagata, Yukihiro

doi:10.1016/s0378-5122(99)00114-0

Cited by 76 publications

(51 citation statements)

References 14 publications

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“…Some of the previous studies reported differences in body composition bone mineral relationships between premenopausal and postmenopausal women [10][11][12]. MacInnis et al [12] in a co-twin study on 30 to 65 year old women have shown the importance of the separation of the study subjects into two groups according to menopausal status.…”

Section: Discussionmentioning

confidence: 97%

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Gender differences in relationships between body composition components, their distribution and bone mineral density: a cross-sectional opposite sex twin study

2005

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Section: Discussionmentioning

confidence: 97%

“…A few studies have compared the relationship between body composition and bone mass in preand postmenopausal women [10][11][12], but there are no studies that have compared such relations in males of different age groups.…”

Section: Introductionmentioning

confidence: 99%

Gender differences in relationships between body composition components, their distribution and bone mineral density: a cross-sectional opposite sex twin study

2005

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“…However, the subjects of their study were older and postmenopausal women. Douchi et al (30) reported that lean mass rather than fat mass was a significant determinant of not only regional BMD but also total body BMD in pre-menopausal women. That is to say, in pre-menopausal females with regular menstruation, the effects on BMD of estrogen synthesized in adipose tissue are smaller because of female uterine hormone secretions.…”

Section: Discussionmentioning

confidence: 99%

Correlation between forearm bone mineral density and body composition in Japanese females aged 18–40 years

Arimatsu

Kitano

et al. 2005

Environ Health Prev Med

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Objective: The purpose of this study was to clarify the relationship between forearm bone mineral density (BMD), body mass index (BMI), and body composition focusing on body fat percentage (BF%) in Japanese females 18 to 40 years old.Methods: Subjects were 2,280 females 18-40 years old. Anthropometric measurements were taken, and a medical history was obtained by questionnaire, including age at the time of the study and age at menarche. BF% was measured by bioelectrical impedance analysis. Forearm BMD was measured using dual-energy X-ray absorptiometry (DXA). The correlations of BMD with BMI and BF% were analyzed using a structural equation model.Results: The standardized regression coefficients for the path from BMI to BMD and the path from BF% to BMD were 0.538 and −0.184 respectively. The squared multiple correlation of BMD was 0.146. In addition, the standardized regression coefficient for the path from BMI to BF% was 0.896.Conclusion: The results showed a positive correlation between BMD and BMI and an inverse correlation between BMD and BF%. At the same time, it was noted that BF% increased with BMI. This indicated that BMD is dependant on BF% in subjects who have a similar BMI. Therefore, this study concluded that it is necessary to take body composition measurements into account when examining the relationship between BMI and BMD, especially in young females.

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“…It has been demonstrated that postmenopausal women who are ≥ 30% overweight exhibit higher BMD measured at lumbar spine (L 2 -L 4 ), proximal femur and the radius compared to slim postmenopausal women [58,60,61,64]. Numerous authors have emphasised a significant positive correlation between BMI and BMD measured at lumbar spine and proximal epiphysis of the femur [58,60,61].…”

Section: Discussionmentioning

confidence: 99%

Wybrane hormony tkanki tłuszczowej, metabolizm kostny a osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u otyłych kobiet po menopauzie

Ostrowska

Świętochowska

Marek

et al. 2015

Endokrynologia Polska

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Selected adipose tissue hormones, bone metabolism, osteoprotegerin and receptor activator of nuclear factor-kB ligand in postmenopausal obese women Wybrane hormony tkanki tłuszczowej, metabolizm kostny a osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u otyłych kobiet po menopauzie AbstractIntroduction: It has been suggested that changes in the production of adipose tissue hormones in obese postmenopausal women might affect their bone status. The aim of this study was to determine whether obese postmenopausal women exhibited any relationship between serum levels of LP, ADIPO, RES, VISF, APE and bone metabolism markers (OC and CTx), OPG, sRANKL, the OPG/sRANKL ratio as well as BMD. Material and methods: 80 postmenopausal women (60 obese and 20 healthy) underwent BMD measurement using dual-energy X-ray absorptiometry (DXA) at lumbar spine L 2 -L 4 . Serum levels of selected adipose tissue hormones, OC, CTx, OPG and its soluble ligand, sRANKL, were assessed by ELISA. Results:Obese postmenopausal women demonstrated a significant increase in body mass, BMI and WHR associated with significant increases in LP and RES levels, a decrease in ADIPO concentration, suppression of OC, CTx, OPG and sRANKL and an increase in the OPG/sRANKL ratio and BMD. BMI correlated positively with BMD, LP, RES, OPG and the OPG/sRANKL ratio, whereas in the case of ADIPO, OC, CTx, sRANKL the relationship was negative. WHR was positively correlated with the OPG/sRANKL ratio, and negatively with ADIPO and APE. A positive correlation was found between BMD and LP, APE and the OPG/sRANKL ratio, while the correlation between BMD and ADIPO, CTx, sRANKL was negative. Significant positive correlations were also revealed between OC, CTx and ADIPO; OPG and ADIPO; sRANKL and ADIPO, RES; the OPG/sRANKL ratio and LP. OC correlated negatively with LP, RES, VISF, APE; CTx with LP, VISF, APE; OPG with LP; sRANKL with LP and APE; the OPG/sRANKL ratio with VISF. ADIPO was an independent predictor of OC, OPG and sRANKL, while LP turned out to be an independent predictor of CTx, OPG, sRANKL and the OPG/sRANKL ratio. Conclusions: Obesity in postmenopausal women can lead to changes in BMD, circulating levels of bone markers, OPG, sRANKL and/or the OPG/sRANKL ratio; these changes are associated with alterations in the concentrations of adipose tissue hormones under investigation. The relationships between bone status indicators and adipose tissue hormones, especially LP and ADIPO, seem to suggest that changes in these hormones observed in obese postmenopausal women might have a protective effect on bone tissue, most probably via a shift in the OPG/sRANKL ratio towards a functional excess of OPG. (Endokrynol Pol 2014; 65 (6): 438-448)

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Difference in the effect of adiposity on bone density between pre- and postmenopausal women

Cited by 76 publications

References 14 publications

Gender differences in relationships between body composition components, their distribution and bone mineral density: a cross-sectional opposite sex twin study

Gender differences in relationships between body composition components, their distribution and bone mineral density: a cross-sectional opposite sex twin study

Correlation between forearm bone mineral density and body composition in Japanese females aged 18–40 years

Wybrane hormony tkanki tłuszczowej, metabolizm kostny a osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u otyłych kobiet po menopauzie

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