Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARα and SREBP-1c in rats

Kim, Myung-Joo; Sim, Mi-Ok; Lee, Hae-In; Ham, Ju Ri; Seo, Kwon‐Il; Lee, Mi-Kyung

doi:10.1016/j.alcohol.2014.08.008

Cited by 32 publications

(27 citation statements)

References 51 publications

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“…However, little was previously known about how different ratios of DHA/EPA affect various pathways involved in lipid metabolism in the liver. Thus, in order to understand the mechanism of action underlying the differences in lipid profile and liver lipid deposition caused by DHA/EPA supplementation, the mRNA expression levels of the following proteins were analyzed: SREBP-1C [26], SCD-1 [27], FAS [28], ACC-1 [4], and HSL [29], which are proteins involved in lipogenesis; and AMPK [30], PPARα [31], PPARγ [31], CPT-1 [32], and ACOX [8], which are proteins involved in fatty acid oxidation. Mice treated with DHA/EPA showed promotion of the expression of Fra1 protein and its relative mRNA expression, and inhibition of the expression of PPARγ mRNA, which potentially indicated that DHA/EPA exert their effects on lipid metabolic modulation by accelerating the expression of Fra1 and restraining the expression of PPARγ, and thereby suppressing the expression of their downstream adipogenic genes.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice

et al. 2017

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BackgroundA sedentary lifestyle and poor diet are risk factors for the progression of non-alcoholic fatty liver disease. However, the pathogenesis of hepatic lipid accumulation is not completely understood. Therefore, the present study explored the effects of dietary supplementation of various ratios of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on a high-fat diet-induced lipid metabolism disorder and the concurrent liver damage.MethodsUsing high-fat diet-fed C57BL/6 J mice as the animal model, diets of various ratios of DHA/EPA (2:1, 1:1, and 1:2) with an n-6/n-3 ratio of 4:1 were prepared using fish and algae oils enriched in DHA and/or EPA and sunflower seed oils to a small extent instead of the high-fat diet.ResultsSignificantly decreased hepatic lipid deposition, body weight, serum lipid profile, inflammatory reactions, lipid peroxidation, and expression of adipogenesis-related proteins and inflammatory factors were observed for mice that were on a diet supplemented with DHA/EPA compared to those in the high-fat control group. The DHA/EPA 1:2 group showed lower serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein-cholesterol levels, lower SREBP-1C, FAS, and ACC-1 relative mRNA expression, and higher Fra1 mRNA expression, with higher relative mRNA expression of enzymes such as AMPK, PPARα, and HSL observed in the DHA/EPA 1:1 group. Lower liver TC and TG levels and higher superoxide dismutase levels were found in the DHA/EPA 2:1 group. Nonetheless, no other notable effects were observed on the biomarkers mentioned above in the groups treated with DHA/EPA compared with the DHA group.ConclusionsThe results showed that supplementation with a lower DHA/EPA ratio seems to be more effective at alleviating high-fat diet-induced liver damage in mice, and a DHA/EPA ratio of 1:2 mitigated inflammatory risk factors. These effects of n-3 polyunsaturated fatty acids (PUFA) on lipid metabolism may be linked to the upregulation of Fra1 and attenuated activity of c-Jun and c-Fos, thus ultimately reducing the severity of the lipid metabolism disorder and liver damage to some extent.

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Section: Discussionmentioning

confidence: 99%

Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice

et al. 2017

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“…UMB has been reported to exhibit neuroprotective effects in MPTP-induced mouse model and cross the blood-brain barrier, indicating that UMB has the potential to protect neuron from apoptosis [9]. UMB positively regulates peroxisome proliferator-activated receptor-␥ (PPAR-␥) activity and this action is involved in amelioration of metabolic disorders and alcohol-induced fatty liver [10][11][12]. PPAR-␥, belonging to the nuclear hormone receptor superfamily, has been certified as an important regulator of apoptosis, oxidative stress and inflammation [13][14][15], and also plays a significant role in the neuroprotection against cerebral ischemia-reperfusion injury [16].…”

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confidence: 99%

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

Wang

et al. 2015

Neuroscience Letters

110

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“…The compound lowers serum GLU (glucose) level in rats with streptozotocin diabetes, exhibit antioxidant, antinociceptive and anti-inflammatory effects, is used as derivative in the synthesis of drugs [2][3][4][5][6][7]. The recent study showed that HOC is α-amylase and α-glucosidase inhibitor in vitro [8], causes neuroprotective effects [9,10], attenuate alcohol-induced fatty liver in rats [11]. The abovementioned points that HOC might be considered either as a promising pharmaceutical agent, or as a biologically active food additive.…”

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confidence: 99%

Single and Repeat Dose Toxicity Study of 7-Hydroxycoumarin, Ethanol, and Their Mixture in Rats

Zinovieva¹,

Zhminko²

2017

JPP

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Acute and repeat-dose toxic effects of HOC (7-hydroxycoumarin), ethanol and their mixture were studied in rats. Single oral administration of HOC (5,000 mg/kg) caused transitional glycosuria associated with lowered serum glucose levels, decreased urea clearance. HOC given orally during 28 days (200 mg/kg) decreased serum glucose, and increased serum triglyceride concentrations. No enhancement of acute toxic effect of HOC (5,000 mg/kg) and ethanol (6,000 mg/kg) mixture was found in the acute toxicity study phase. Effect of HOC (200 mg/kg) and ethanol (750 mg/kg) during 28 days of exposure was less pronounced in comparison with HOC effect only, as far as neither decrease of glucose, nor increase of triglyceride serum concentrations were found.

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Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARα and SREBP-1c in rats

Cited by 32 publications

References 51 publications

Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice

Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

Single and Repeat Dose Toxicity Study of 7-Hydroxycoumarin, Ethanol, and Their Mixture in Rats

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