Dietary supplementation with specific oligosaccharide mixtures decreases parameters of allergic asthma in mice

Vos, Anneke S. de; Esch, Betty C.A.M. van; Stahl, Bernd; M’Rabet, Laura; Folkerts, Gert; Nijkamp, Frans P.; Garssen, Johan

doi:10.1016/j.intimp.2007.07.024

Cited by 117 publications

(97 citation statements)

References 27 publications

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“…A specific scGOS/lcFOS mixture was shown to reduce the allergic reaction against ovalbumin in mice. 53 GOS/FOS in dietary products was shown to possibly provide an opportunity to stimulate the adaptive immune response in a Th1-direction and subsequently inhibit infections and Th2-related immune disorders in humans, such as allergies. 51 GOS blocks atopic dermatitis in mice by at least partly inducing production of IL-10 and suppressing the production of cytokines such as IL-17, which are involved in skin inflammation.…”

Section: Prebiotics and Allergy And Atopic Dermatitismentioning

confidence: 99%

Prebiotics in infant formula

2014

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The gastrointestinal microbiota of breast-fed babies differ from classic standard formula fed infants. While mother's milk is rich in prebiotic oligosaccharides and contains small amounts of probiotics, standard infant formula doesn't. Different prebiotic oligosaccharides are added to infant formula: galacto-oligosaccharides, fructo-oligosaccharide, polydextrose, and mixtures of these. There is evidence that addition of prebiotics in infant formula alters the gastrointestinal (GI) microbiota resembling that of breastfed infants. They are added to infant formula because of their presence in breast milk. Infants on these supplemented formula have a lower stool pH, a better stool consistency and frequency and a higher concentration of bifidobacteria in their intestine compared to infants on a non-supplemented standard formula. Since most studies suggest a trend for beneficial clinical effects, and since these ingredients are very safe, prebiotics bring infant formula one step closer to breastmilk, the golden standard. However, despite the fact that adverse events are rare, the evidence on prebiotics of a significant health benefit throughout the alteration of the gut microbiota is limited.

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Section: Prebiotics and Allergy And Atopic Dermatitismentioning

confidence: 99%

Prebiotics in infant formula

2014

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“…The effects of scGOS and lcFOS (9:1)(Immunofortis®) have been studied in a murine vaccination model (Vos, Haarman et al 2006), in an allergic asthma model (Vos, van Esch et al 2007) and a cow's milk allergy model (Schouten, van Esch et al 2009). The response to vaccination of mice fed the scGOS/lcFOS diet was significant enhanced, as well as the fecal Bifidobacteria and Lactobacilli proportions.…”

Section: Nondigestible Oligosaccharidesmentioning

confidence: 99%

Development of the Immune System - Early Nutrition and Consequences for Later Life

Kerperien¹,

Schouten²,

Boehm³

et al. 2012

Recent Advances in Immunology to Target Cancer, Inflammation and Infections

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“…In allergic asthmatic adults, allergen-specific Th2-response was reduced and peak expiratory flow was improved by this same combination [35] . In another study, the same mixture prevented asthma-like symptoms in infants with atopic dermatitis [36] . In mice, several parameters of allergic asthma were reduced by a specific mixture of oligosaccharides consisting of scGOS/lcFOS and scGOS/lcFOS/pectin-derived acidic oligosaccharides (pAOS) [36] .…”

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confidence: 91%

Beneficial bacteria as a treatment for allergic asthma

2014

Inflamm Cell Signal

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The limitations of the current therapy for allergic asthma highlight the need for novel therapeutics with longterm benefits, greater disease control and increased efficacy. Interventions targeting the gut microbiota have gained a lot of attention as a treatment approach for a range of allergic disorders. In accord, there is a growing interest in the use of potentially beneficial bacteria as a therapy for allergic asthma. Animal models played a key role in the understanding of the immunomodulatory capacity of specific bacteria. These models revealed that the gut microbiota can influence the immune function beyond the gut. Therapeutic effects of beneficial bacteria alone or in combination with non-digestible oligossachrides in animal models included reducing allergic airway responses and allergic symptoms. Beneficial bacteria-based therapeutic strategies proved also to be useful in patients, reducing the allergic response and preventing asthma-like symptoms. Studies conducted so far indicate clear bacterial strains-dependent treatment effects. A better understanding of the cross talk between the administered beneficial bacteria and the host mucosal immune system is required before clinically effective bacteria-based strategies can be developed. This brief review addresses current evidence for the potential of beneficial bacteria as a treatment approach for allergic asthma and discusses opportunities for beneficial bacteria interventions in allergic asthma.

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Dietary supplementation with specific oligosaccharide mixtures decreases parameters of allergic asthma in mice

Cited by 117 publications

References 27 publications

Prebiotics in infant formula

Prebiotics in infant formula

Development of the Immune System - Early Nutrition and Consequences for Later Life

Beneficial bacteria as a treatment for allergic asthma

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