Dietary Supplementation with a Low Dose of Polyphenol-Rich Grape Pomace Extract Prevents Dextran Sulfate Sodium-Induced Colitis in Rats

Abstract

Evidence from several epidemiological and experimental studies points to a beneficial role of dietary polyphenols in inflammatory bowel disease. In this study, we investigate the protective effect of dietary supplementation with various amounts of a polyphenol-rich grape pomace extract (GPE) on the development of dextran sulfate sodium (DSS)-induced colitis in rats. Rats were fed 21 days on a semisynthetic diet enriched with GPE (0.1%, 0.5%, and 1%), and acute colitis was induced by DSS (40 g/L in the drinking water) administration during the last 7 days. The low GPE content in the diet (0.1%) attenuated clinical signs and colon shortening and limited DSS-induced histological lesions. GPE 0.1% also attenuated the DSS-induced increase in myeloperoxidase activity and improved superoxide dismutase activity. Higher amounts of GPE in the diet induced only weak and nonsignificant protective effects. These results suggest that consumption of a low amount of polyphenol-rich GPE helps protect against colitis development.

Functional Anthocyanin-Rich Sausages Diminish Colorectal Cancer in an Animal Model and Reduce Pro-Inflammatory Bacteria in the Intestinal Microbiota

“…In Figure 1 , considerable decelerations in weight gain at those points in the experiment can be observed, especially in the rats from the feed and control sausage cohorts. A possible explanation for this apparent protection against AOM and/or DSS inflammation in the case of the functional sausage cohort may be the known anti-inflammatory effect of anthocyanins [ 19 , 20 , 21 , 22 , 41 ].…”

Exploring the effects of phenolic compounds to reduce intestinal damage and improve the intestinal barrier integrity: A systematic review of in vivo animal studies

“…Regarding the animal models used in the 14 included in vivo animal studies: Wistar rats (n ¼ 4) [31,34,36,40], C57BL/10 SnSn mice (n ¼ 1) [35], C57BL/6J mice (n ¼ 1) [37], both C57BL/6 and IL-deficient mice (n ¼ 1) [38], both C57BL/6 and CD1 mice (n ¼ 1) [41], C57BL/6 mice alone (n ¼ 1) [43], weaned pigs (n ¼ 2) [33,44], SpragueeDawley rats (n ¼ 1) [32], IL-10 deficient mice (n ¼ 1) [39], and BALB/C mice (n ¼ 1) [45]. The current animal models used to assess intestinal inflammation are summarized in Table 1.…”

“…In in vivo animal studies, resveratrol as an extract was the most commonly used source of PCs (n ¼ 6) [31,32,34,35,44,45]; after its oral (n ¼ 5) [31,34,35,44,45], or intravenous administration (n ¼ 1) [32]. Other PC sources used in in vivo animal studies were: oral grape seed extract (GSE) (n ¼ 2) [38,39], oral grape pomace extract (n ¼ 1) [40], oral cranberry extract (n ¼ 1) [37], oral curcumin (n ¼ 1) [35], oral hesperidin (n ¼ 1) [43], oral Olive (Olea europaea) leaves extract (n ¼ 1) [41], genistein by intestinal injection (n ¼ 1) [36], and oral chlorogenic acid (n ¼ 1) [33]. Complete information on the included animal studies is reported in Table 2.…”

Encapsulación de extractos antioxidantes desde sub-productos agroindustriales: una revisión

“…En algunos de estos sub-productos también están presentes taninos, vitaminas, carotenos, pigmentos y otros. En los últimos años se han publicado diversos estudios que señalan que los compuestos bioactivos naturales extraídos de los vegetales son beneficiosos para la salud humana ya que poseen actividad antioxidante, tienen propiedades anticancerígenas, cardioprotectoras, antimicrobianas y antiinflamatorias 10,23,32,33 . Por esto la extracción de este tipo de compuesto en conjunto con el concepto de economía circular, es un "hot topic" en la actualidad.…”