Dietary <scp>d</scp>‐Psicose Reduced Visceral Fat Mass in High‐Fat Diet‐Induced Obese Rats

Chung, Young Mee; Lee, Juhyun; Kim, Deuk Youl; Hwang, Se Hee; Hong, Young Ho; Kim, Seong Bo; Lee, Song Jin; Park, Chi Hye

doi:10.1111/j.1750-3841.2011.02571.x

Cited by 66 publications

(52 citation statements)

References 26 publications

(27 reference statements)

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“…Therefore, the dose applied in the present study is considered physiologically appropriate and safe for examining the effects of D-xylose on adipogenesis and lipid metabolism. Several dietary carbohydrates have been tested for their effects on blood glucose levels, adipose tissue mass, and blood lipid profiles [58,59]. Moreover, L-arabinose, another sucrose inhibitor, has been found to reduce postprandial blood glucose levels after the intake of sucrose [58] and Dpsicose, a C-3 epimer of D-fructose, reduced visceral fat mass in HFD-induced obese rats [59].…”

Section: Discussionmentioning

confidence: 99%

“…Several dietary carbohydrates have been tested for their effects on blood glucose levels, adipose tissue mass, and blood lipid profiles [58,59]. Moreover, L-arabinose, another sucrose inhibitor, has been found to reduce postprandial blood glucose levels after the intake of sucrose [58] and Dpsicose, a C-3 epimer of D-fructose, reduced visceral fat mass in HFD-induced obese rats [59]. Further studies are needed to study differences in specificity for various carbohydrate digestive enzymes in response to sucrose-based dietary carbohydrates.…”

Section: Discussionmentioning

confidence: 99%

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d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

Lim

Shin

et al. 2015

Nutrition Research

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

Lim

Shin

et al. 2015

Nutrition Research

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“…In animal studies investigating the anti-obesity effects of d-allulose, d-allulose content in the diet was mainly set at the level of 3% (27) or 5% (11,12,15,28), although the carbohydrate source in the diets and the animal model varied depending on studies. Our previous study (28) reported that a 5% d-allulose diet for 8 wk significantly suppressed body fat accumulation and increased energy expenditure in rats fed a sucrose-based diet.…”

Section: Resultsmentioning

confidence: 99%

“…Among rare sugar sweeteners, d-allulose (d-ribo-2-hexulose), which was previously referred to d-psicose, has recently received much attention as a potential anti-diabetic and anti-obesity ingredient (8)(9)(10)(11)(12)(13)(14)(15), and has not shown adverse effects that are observed in conventional non-or low-calorie sweeteners.…”

mentioning

confidence: 99%

Comparison of Anti-Obesity Effect between Two Types of Syrup Containing Rare Sugars in Wistar Rats

Ochiai

Misaki

Yamada

et al. 2017

J Nutr Sci Vitaminol

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Summary d-Allulose-containing rare sugar sweeteners have been categorized into two types, rare sugar syrup (RSS), consisting of 4 rare monosaccharides, and modified glucose syrup (MGS), rich in d-allulose, which was previously referred to d-psicose. The anti-obesity effect of RSS and d-allulose has been already clarified, but that of rare monosaccharides other than d-allulose in RSS has not yet been well understood. Here, we investigated and compared the anti-obesity effect of RSS and MGS in rats. Male Wistar rats were divided into 4 dietary groups: a high-sucrose control diet group (S), a high-fructose corn syrup diet group (HFCS), an RSS diet group (RSS), and an MGS diet group (MGS). RSS significantly suppressed abdominal adipose tissue weight and total body fat accumulation in comparison to sucrose. On the other hand, MGS reduced body weight gain, but not abdominal fat accumulation, relative to sucrose. The weight of the liver and kidneys was significantly higher in the RSS and MGS groups than in the S and HFCS groups, but serum biochemical parameters and hepatic lipids contents were not significantly different among the groups. The present study shows that two types of d-allulose-containing rare sugar sweeteners can suppress body fat accumulation or weight gain in a different manner and that RSS could be used as more effective sweeteners in place of sucrose and HFCS to maintain healthy body weight.

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“…Due to its high-calorie content, feeding a HFD was expected to promote live weight gain. Chung et al (27) found that Sprague-Dawley rats fed a HFD (3.85 kcal/kg energy) compared with rats fed a standard diet (4.65 kcal/kg energy) for 4 weeks had an increase in weight gain. Sahin et al (28) also found that rats fed a HFD for 12 weeks had greater body weights compared with rats fed a regular diet.…”

Section: Discussionmentioning

confidence: 99%

Combined oral supplementation of chromium picolinate, docosahexaenoic acid, and boron enhances neuroprotection in rats fed a high-fat diet

Orhan¹,

Şahin²,

Tuzcu³

et al. 2017

Turk J Med Sci

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Background/aim: A novel complex of a nutritional supplement (CDB) contains chromium picolinate (CrPic), phosphatidylserine (PS), docosahexaenoic acid (DHA), and boron (B). The present study aimed to investigate the effects of CDB on the metabolic profile and memory acquisition in rats fed a high-fat diet (HFD).Materials and methods: Male Wistar rats were divided into six groups and received either a regular diet or HFD supplemented with or without different levels of CDB (0, 11, or 22 mg/kg BW).Results: Rats fed the HFD had greater glucose, insulin, lipid profile, and serum malondialdehyde concentrations, but lower serotonin and tryptophan in the serum and brain and lower Cr concentrations in serum, kidney, brain, and liver (P < 0.0001). CDB complex supplementation reversed all the effects, and the reversal effect was more pronounced with HFD for some parameters. Latency was less (P < 0.05) but probe was greater (P < 0.0001) for rats fed a regular diet. Increasing CDB complex levels in the diets resulted in a linear decrease in latency (P < 0.0002) but a linear increase in probe (P < 0.0002). Conclusion:Findings of the present work indicate that the CDB complex could be considered as an alternative treatment for preventing certain metabolic diseases and improving neurological functions, such as learning and memory.

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Dietary d‐Psicose Reduced Visceral Fat Mass in High‐Fat Diet‐Induced Obese Rats

Cited by 66 publications

References 26 publications

d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

d-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet–induced obese mice

Comparison of Anti-Obesity Effect between Two Types of Syrup Containing Rare Sugars in Wistar Rats

Combined oral supplementation of chromium picolinate, docosahexaenoic acid, and boron enhances neuroprotection in rats fed a high-fat diet

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