Combined oral supplementation of chromium picolinate, docosahexaenoic acid, and boron enhances neuroprotection in rats fed a high-fat diet

Abstract

Background/aim: A novel complex of a nutritional supplement (CDB) contains chromium picolinate (CrPic), phosphatidylserine (PS), docosahexaenoic acid (DHA), and boron (B). The present study aimed to investigate the effects of CDB on the metabolic profile and memory acquisition in rats fed a high-fat diet (HFD).Materials and methods: Male Wistar rats were divided into six groups and received either a regular diet or HFD supplemented with or without different levels of CDB (0, 11, or 22 mg/kg BW).Results: Rats fed the HFD had greater glucose, insulin, lipid profile, and serum malondialdehyde concentrations, but lower serotonin and tryptophan in the serum and brain and lower Cr concentrations in serum, kidney, brain, and liver (P < 0.0001). CDB complex supplementation reversed all the effects, and the reversal effect was more pronounced with HFD for some parameters. Latency was less (P < 0.05) but probe was greater (P < 0.0001) for rats fed a regular diet. Increasing CDB complex levels in the diets resulted in a linear decrease in latency (P < 0.0002) but a linear increase in probe (P < 0.0002). Conclusion:Findings of the present work indicate that the CDB complex could be considered as an alternative treatment for preventing certain metabolic diseases and improving neurological functions, such as learning and memory.

The addition of an amylopectin/chromium complex to branched-chain amino acids enhances muscle protein synthesis in rat skeletal muscle

“…Previous studies have that chromium enhances GLUT-4 translocation by increasing insulin receptor activation, which results in improved insulin sensitivity and glucose uptake [23]. For instance, studies done by our groups and others have reported that chromium picolinate (CrPic)/chromium histidinate (CrHis) may enhance carbohydrate and lipid metabolism by regulation of glucose transporters, PPAR-γ and p-IRS-1 expression, and other insulin metabolism aspects [22][23][24]45]. It has also been reported that CrHis/CrPic elevates liver GLUT-2 levels, as well as muscle Nrf2 and GLUT-4 levels, and reduces muscle NF-κB levels, with CrHis being superior to CrPic [46].…”

Alzheimer ve Parkinson Hastalıklarında Bor İçeren Bileşiklerin Nörokoruyucu Etkisi

“…500 ve 1000 mg/kg bakır kaynaklı toksisiteye maruz kalan gökkuşağı alabalığı (Oncorhynchus mykiss)'nın beyin dokusunda 1,25, 2,5, ve 5 mg/kg diyet boraksının nöroprotektif etkilerinin değerlendirildiği bir çalışmada, boraksa maruz bırakılan balık beyinlerindeki SOD, [72]. Yüksek yağlı diyetle beslenen sıçanlarda, krom pikolinat, fosfatidilserin, dokosaheksaenoik asit ve bor içeren yeni bir besin takviyesinin, Nrf2/heme oksijenaz 1 (Nrf2/HO-1) antioksidan yolağını aktive ederek beyni oksidatif strese karşı koruduğunu [73], bununla birlikte krom pikolinat, dokosaheksaenoik asit ve bor içeren besin takviyesinin, yüksek yağlı diyetin neden olduğu oksidatif hasarı geri çevirdiğini bildirmişlerdir [74]. Besin takviyesi olarak borun, yüksek yağlı diyet kaynaklı oksidatif strese karşı spesifik nöroprotektif etkileri olduğu rapor edilmiştir [73,74].…”

Insulin-like growth factor 1 in heat stress-induced neuroinflammation: novel perspective about the neuroprotective role of chromium

“…Dietary supplementation of Cr was shown to alleviate post-stroke brain infarction and hyperglycemia in rats (Chen et al 2016 ). Oral Cr administration was found to increase concentrations of 5-hydroxytryptamine and tryptophan in the serum and brain, improving neurological function in terms of learning and memory (Orhan et al 2017 ). More importantly, in depression, a condition extremely harmful to people's mental health, the administration of low-dose antidepressants supplemented with Cr was found to be an effective mitigation method (Młyniec et al 2014 ; Khodavirdipour et al 2020 ).…”