Dietary regulation of adiponectin by direct and indirect lipid activators of nuclear hormone receptors

Rühl, Ralph; Landrier, Jean‐François

doi:10.1002/mnfr.201500619

Cited by 28 publications

(22 citation statements)

References 102 publications

(137 reference statements)

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“…The beneficial effects of magnesium intake on blood lipid parameters may be explained by the regulatory roles on the activity of lipoprotein lipase, fatty acid desaturase and lecithin‐cholesterol acyl transferase which are involved in the maintaining lipoprotein balance and fatty acid oxidation . Moreover, vitamin E induces adiponectin expression which involved in the regulation of glucose and lipid metabolism . In addition, vitamin E mediates carbohydrate metabolism through the increasing of intracellular magnesium and glutathione levels …”

Section: Discussionmentioning

confidence: 99%

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Afzali

Kashi

Momen‐Heravi

et al. 2019

Wound Repair Regeneration

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This study was carried out to determine the effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 57 patients with grade 3 DFU. Participants were randomly divided into two groups to take either 250 mg magnesium oxide plus 400 IU vitamin E (n = 29) or placebo per day (n = 28) for 12 weeks. Compared with the placebo, taking magnesium plus vitamin E supplements reduced ulcer length (β [difference in the mean of outcomes measures between treatment groups] −0.56 cm; 95% CI, −0.92, −0.20; p = 0.003), width (β −0.35 cm; 95% CI, −0.64, −0.05; p = 0.02) and depth (β −0.18 cm; 95% CI, −0.33, −0.02; p = 0.02). In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β −13.41 mg/dL; 95% CI, −20.96, −5.86; p = 0.001), insulin (β −1.45 μIU/ml; 95% CI, −2.37, −0.52; p = 0.003), insulin resistance (β −0.60; 95% CI, −0.99, −0.20; p = 0.003) and HbA1c (β −0.32%; 95% CI, −0.48, −0.16; p < 0.003), and a significant elevation in insulin sensitivity (β 0.007; 95% CI, 0.003, 0.01; p < 0.001) compared with the placebo. Additionally, compared with the placebo, taking magnesium plus vitamin E supplements decreased triglycerides (β −10.08 mg/dL; 95% CI, −19.70, −0.46; p = 0.04), LDL-cholesterol (β −5.88 mg/dL; 95% CI, −11.42, −0.34; p = 0.03), high sensitivity C-reactive protein (hs-CRP) (β −3.42 mg/L; 95% CI, −4.44, −2.41; p < 0.001) and malondialdehyde (MDA) (β −0.30 μmol/L; 95% CI, −0.45, −0.15; p < 0.001), and increased HDL-cholesterol (β 2.62 mg/dL; 95% CI, 0.60, 4.63; p = 0.01) and total antioxidant capacity (TAC) levels (β 53.61 mmol/L; 95% CI, 4.65, 102.57; p = 0.03). Overall, magnesium and vitamin E co-supplementation for 12 weeks to patients with DFU had beneficial effects on ulcer size, glycemic control, triglycerides, LDL-and HDL-cholesterol, hs-CRP, TAC, and MDA levels.The diabetic foot ulcer (DFU) is a chronic consequence of diabetes mellitus which mainly caused by neuropathy, different grades of ischemia, and infection that coincide with poor glycemic control and diminished neutrophil function. 1 The mortality rate among diabetic patients with DFU is higher than twofold compared with nonulcer patients. 2 Based on the previous evidence, the effective management of diabetes and timely treatment of foot ulcer are implicated for decrease the morbidity and mortality of DFU. 3 The nutritional status of diabetic patients correlates with the severity of ulcer and play an important role in the reversing of wound risk. 4 According to the prior studies, the alternation of magnesium metabolism is a common feature in diabetic patients which interference with glycemic control and contributes to impaired insulin sensitivity and chronic inflammatory status. 5In addition, observational evidence shown that there is an inverse association between magnesium levels and the occurrence of foot ulcers, nephropathy and retinopathy. 6 Similarly, it is repo...

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Section: Discussionmentioning

confidence: 99%

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Afzali

Kashi

Momen‐Heravi

et al. 2019

Wound Repair Regeneration

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“…9CDHRA can activate RXR and via this route also initiate nonpermissive heterodimers, such as RXR-PPAR, RXR-liver X receptors (LXRs), RXR-farnesoid receptors (FXR) and RXR-nuclear hormone receptor 4A (NR4A) protein, involved in the expression of a wide array of genes involved in inflammation and lipid metabolism, as reviewed in Desvergne (161) . A large overlap was found between beneficial anti-inflammatory effects of carotenoids in general and lipid metabolism for many RXR-heterodimer-mediated signalling pathway targets (131,(161)(162)(163)(164)(165)(166) .…”

Section: β-Carotene Bioactivation Pathway 75mentioning

confidence: 99%

β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion

Bohn

Desmarchelier

et al. 2019

Proc. Nutr. Soc.

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5Paprika Bioanalytics BT, Debrecen, Hungary β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor-and retinoid X receptor-mediated signalling. To better understand the metabolic conversion of β-carotene, inter-individual differences regarding β-carotene bioavailability and bioactivity are key steps that determine its further metabolism and bioactivation and mediated signalling. Major carotenoid metabolites, the retinoids, can be stored as esters or further oxidised and excreted via phase 2 metabolism pathways. In this review, we aim to highlight the major critical control points that determine the fate of β-carotene in the human body, with a special emphasis on β-carotene oxygenase 1. The hypothesis that higher dietary β-carotene intake and serum level results in higher β-carotene-mediated signalling is partly questioned. Alternative autoregulatory mechanisms in β-carotene / retinoid-mediated signalling are highlighted to better predict and optimise nutritional strategies involving βcarotene-related health beneficial mediated effects.

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“…This adipokine has insulin-sensitisation properties of the target cells (liver, skeletal muscle and adipose tissue) and can enhance glucose uptake in muscle tissue (11)(12)(13) . Adiponectin also protects β-cells from immune attack and reduces insulin resistance through immunoregulatory and anti-inflammatory effects (11)(12)(13)(14) . In pregnant women, concentrations of adiponectin have been inversely associated with adverse maternal outcomes, such as GDM (15,16) , overweight and obesity (17) .…”

mentioning

confidence: 99%

“…Many factors can influence the expression of this adipokine. Vitamin D concentration is one example (13,20) , as it down-regulates pro-inflammatory cytokines and up-regulates anti-inflammatory cytokines. Vitamin D appears to be positively associated with adiponectin gene expression and suppresses the renin-angiotensin-aldosterone system (RAAS) components secreted by adipocytes, thus contributing to increased adiponectin secretion (20)(21)(22) .…”

mentioning

confidence: 99%

Longitudinal association of 25-hydroxyvitamin D with adipokines and markers of glucose metabolism among Brazilian pregnant women

Benaim

Cocate

Barros³

et al. 2018

Br J Nutr

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This study aimed to evaluate the longitudinal association of vitamin D status with glycaemia, insulin, homoeostatic model assessment of insulin resistance, adiponectin and leptin. A prospective cohort with 181 healthy, pregnant Brazilian women was followed at the 5th–13th, 20th–26th and 30th–36th gestational weeks. In this cohort, 25-hydroxyvitamin D (25(OH)D) plasma concentrations were analysed using liquid chromatography–tandem MS. Vitamin D status was categorised as sufficient or insufficient using the Endocrine Society Practice Guidelines (≥75/<75 nmol/l) and the Institute of Medicine (≥50/<50 nmol/l) thresholds. Linear mixed-effect regression models were employed to evaluate the association between vitamin D status and each outcome, considering interaction terms between vitamin D status and gestational age (P<0·1). At baseline, 70·7 % of pregnant women had 25(OH)D levels <75 nmol/l and 16 % had levels <50 nmol/l. Women with sufficient vitamin D status at baseline, using both thresholds, presented lower glycaemia than those with insufficient 25(OH)D. Pregnant women with 25(OH)D concentrations <75 nmol/l showed lower insulin (β=−0·12; 95 % CI −0·251, 0·009;P=0·069) and adiponectin (β=−0·070; 95 % CI −0·150, 0·010;P=0·085) concentrations throughout pregnancy than those with 25(OH)D levels ≥75 nmol/l. Pregnant women with 25(OH)D <50 nmol/l at baseline presented significantly higher leptin concentrations than those with 25(OH)D levels ≥50 nmol/l (β=−0·253; 95 % CI −0·044, 0·550;P=0·095). The baseline status of vitamin D influences the biomarkers involved in glucose metabolism. Vitamin D-sufficient women at baseline had higher increases in insulin and adiponectin changes throughout gestation than those who were insufficient.

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Dietary regulation of adiponectin by direct and indirect lipid activators of nuclear hormone receptors

Cited by 28 publications

References 102 publications

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion

Longitudinal association of 25-hydroxyvitamin D with adipokines and markers of glucose metabolism among Brazilian pregnant women

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