Dietary Reference Intakes for The Antioxidant Nutrients

Monsen, Elaine R

doi:10.1016/s0002-8223(00)00189-9

Cited by 276 publications

(97 citation statements)

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“…The current recommended dietary allowance (RDA) for vitamin C for healthy individuals is 90mg/day for adult males, and 75mg/day for adult females, 15–65mg/day for children depending on age and gender, and 40–50mg/day for infants (14) . In adults, intakes above RDA are recommended during pregnancy, if lactating, and in smokers (additional 15, 50 and 35mg/day, respectively) (14) .…”

Section: Epidemiology and Human Studies In Vitamin Cmentioning

confidence: 99%

“…In adults, intakes above RDA are recommended during pregnancy, if lactating, and in smokers (additional 15, 50 and 35mg/day, respectively) (14) . Based on data from the most recent National Health and Nutrition Examination Survey (NHANES) 2003–2006 (4) , the Center for Disease Control reported the overall prevalence of vitamin C deficiency in the U.S. to be 6%.…”

Section: Epidemiology and Human Studies In Vitamin Cmentioning

confidence: 99%

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The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments

Aghajanian

Hall

Wongworawat

et al. 2015

Journal of Bone and Mineral Research

168

141

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Vitamin C is an important antioxidant and cofactor which is involved in the regulation of development, function and maintenance of several cell types in the body. Deficiencies in vitamin C can lead to conditions such as scurvy, which, among other ailments, causes gingivia, bone pain and impaired wound healing. This review examines the functional importance of vitamin C as it relates to the development and maintenance of bone tissues. Analysis of several epidemiological studies and genetic mouse models regarding the effect of vitamin C shows a positive effect on bone health. Overall, vitamin C exerts a positive effect on trabecular bone formation by influencing expression of bone matrix genes in osteoblasts. Recent studies on the molecular pathway for vitamin C actions that include direct effects of vitamin C on transcriptional regulation of target genes by influencing the activity of transcription factors and by epigenetic modification of key genes involved in skeletal development and maintenance are discussed. With an understanding of mechanisms involved in the uptake and metabolism of vitamin C and knowledge of precise molecular pathways for vitamin C actions in bone cells, it is possible that novel therapeutic strategies can be developed or existing therapies can be modified for the treatment of osteoporotic fractures.

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Section: Epidemiology and Human Studies In Vitamin Cmentioning

confidence: 99%

Section: Epidemiology and Human Studies In Vitamin Cmentioning

confidence: 99%

The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments

Aghajanian

Hall

Wongworawat

et al. 2015

Journal of Bone and Mineral Research

168

141

View full text Add to dashboard Cite

show abstract

“…The diet was prepared using soy oil. According to Slover (1971), every 100 g of refined soy oil contains 10.1 mg of alpha-tocopherol (which corresponds to approximately 4.87 IU of alpha-tocopherol/kg of diet [21]), 59.3 mg of gamma-tocopherol, and 26.4 mg of delta-tocopherol [22]. Table 2 lists the final concentration of VE in the diets.…”

Section: Methodsmentioning

confidence: 99%

Vitamin E Supplementation in Chemical Colorectal Carcinogenesis: A Two-Edged Knife

et al. 2014

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This work investigated the effects of Vitamin E (VE) on aberrant crypt foci (ACF) incidence, oxidative stress parameters (serum and hepatic VE concentration, and homocysteine, glutathione (GSH), and malondialdehyde (MDA) levels), and expression of both cyclooxygenase-2 (COX2) and proliferating cellular nuclear antigen (PCNA) in experimental colorectal carcinogenesis. Male Wistar rats received subcutaneous injections of 1,2-dimethylhydrazine (DMH) twice a week, for two weeks (40 mg/kg), except for the Control group. Animals were separated into groups that received different amounts of VE in the diet: 0 IU (0×), 75 IU (recommended daily intake, RDI), 225 IU (3× RDI), or 1500 IU (20× RDI), during (dDMH) or after (aDMH) administration of carcinogen. The 0×dDMH and 3×dDMH groups showed decreased serum VE levels. Hepatic VE concentration was higher in 3×aDMH as compared with the other groups. All the groups, except the Control and the 0×aDMH groups, had reduced GSH levels. The 0×dDMH, 0×aDMH, and 20×aDMH groups exhibited increased MDA levels. The aDMH groups had higher ACF incidence and PCNA expression. The 0×aDMH group presented higher ACF rate, followed by 20×aDMH. Moreover, the 3×aDMH group displayed reduced ACF incidence and COX2 expression. Multivariate analysis revealed that GSH modulated homocysteine levels and COX2. These results suggested that 1500 IU of VE is hazardous, whereas 225 IU of VE has beneficial effects on chemical colorectal carcinogenesis.

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“…The determination of fat-soluble vitamins A and E plays an important role in nutritional and biochemical studies, and analytical methods available and capable of determining these vitamins in different samples are imperative (6). The possible protective effect of vitamin E against environmental and drug toxicity has also attracted the attention of many investigators (7). The dietary reference intake of vitamin E for an adult person is 15 mg.day -1 (8).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Extraction Parameters for Fat Soluble Vitamins and Major Element Analysis in Polygonum Cognatum Meissn Plant (Madimak)

Ulusoy¹,

Acıdereli²,

Tutar³

2016

Journal of the Turkish Chemical Society, Section A: Chemistry

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Abstract:The concentrations of fat-soluble vitamins (A and E) and various metal ions (Ca, Cd, Cr, Co, Cu, Fe, Mg, Mn, Pb, Zn) have been determined in Polygonum cognatum Meissn plant samples collected in Sivas, Turkey. Analysis of vitamins were carried out by HPLC after Soxhlet extraction and metal ions were determined by FAAS after microwave digestion, respectively. The study is focused on two main purposes: optimization of sample preparing parameters prior to determination and chemical analysis of a common edible plant in Anatolia. There was not enough information about this plant in point of vitamins and various metal species. Consequently, useful and detailed data were introduced to literature for a well-known and so consumed edible plant.

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Dietary Reference Intakes for The Antioxidant Nutrients

Cited by 276 publications

References 0 publications

The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments

The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments

Vitamin E Supplementation in Chemical Colorectal Carcinogenesis: A Two-Edged Knife

Optimization of Extraction Parameters for Fat Soluble Vitamins and Major Element Analysis in Polygonum Cognatum Meissn Plant (Madimak)

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