The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments

Aghajanian, Patrick; Hall, Susan L.; Wongworawat, Montri D.; Mohan, Subburaman

doi:10.1002/jbmr.2709

Cited by 179 publications

(153 citation statements)

References 107 publications

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“…It is important that the patient begins receiving nutritional support in the intensive care unit (ICU) during the initial postoperative course . Vitamin C has long been known to be critically important in the collagen formation of surgical wound healing; however, recent investigations have shown it plays a role in bone healing as well . Selenium is utilised by fibroblasts during the proliferative phase of wound healing and has become an invaluable wound‐healing supplement that is gaining use in postoperative nutritional regimens .…”

Section: Techniquementioning

confidence: 99%

The neurosurgical wound and factors that can affect cosmetic, functional, and neurological outcomes

Berry

Miulli

Lam

et al. 2018

International Wound Journal

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Surgically accessing pathological lesions located within the central nervous system (CNS) frequently requires creating an incision in cosmetic regions of the head and neck. The biggest factors of surgical success typically tend to focus on the middle portion of the surgery, but a vast majority of surgical complications tend to happen towards the end of a case, during closure of the surgical site incisions. One of the most difficult complications for a surgeon to deal with is having to take a patient back to the operating room for wound breakdowns and, even worse, wound or CNS infections, which can negate all the positive outcomes from the surgery itself. In this paper, we discuss the underlying anatomy, pharmacological considerations, surgical techniques and nutritional needs necessary to help facilitate appropriate wound healing. A successful surgery begins with preoperative planning regarding the placement of the surgical incision, being cognizant of cosmetics, and the effects of possible adjuvant radiation therapy on healing incisions. We need to assess patient's medications and past medical history to make sure we can optimise conditions for proper wound reepithelialisation, such as minimizing the amount of steroids and certain antibiotics. Contrary to harmful medications, it is imperative to optimise nutritional intake with adequate supplementation and vitamin intake. The goals of this paper are to reinforce the mechanisms by which surgical wounds can fail, leading to postoperative complications, and to provide surgeons with the reminder and techniques that can help foster a more successful surgical outcome.

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Section: Techniquementioning

confidence: 99%

The neurosurgical wound and factors that can affect cosmetic, functional, and neurological outcomes

Berry

Miulli

Lam

et al. 2018

International Wound Journal

View full text Add to dashboard Cite

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“…It was reported that the antioxidative substance vitamin E could prevent SAON due to its antioxidant property [22]. Vitamin C (VC) is a more portent antioxidant than vitamin E that VC also has benefit effect on bone development and maintenance by promoting genes producing bone matrix in osteoblasts [23]. VC supplementation may therefore attenuate SAON and promote the repair of SAON through its antioxidative effect and bone-anabolic effect.…”

Section: Introductionmentioning

confidence: 99%

Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model

Wang

et al. 2020

Biomaterials

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A B S T R A C TMagnesium (Mg)-based biometal attracts clinical applications due to its biodegradability and beneficial biological effects on tissue regeneration, especially in orthopaedics, yet the underlying anabolic mechanisms in relevant clinical disorders are lacking. The present study investigated the effect of magnesium (Mg) and vitamin C (VC) supplementation for preventing steroid-associated osteonecrosis (SAON) in a rat experimental model. In SAON rats, 50 mg/kg Mg, or 100 mg/kg VC, or combination, or water control was orally supplemented daily for 2 or 6 weeks respectively. Osteonecrosis was evaluated by histology. Serum Mg, VC, and bone turnover markers were measured. Microfil-perfused samples prepared for angiography and trabecular architecture were evaluated by micro-CT. Primary bone marrow cells were isolated from each group to evaluate their potentials in osteoblastogenesis and osteoclastogenesis. The mechanisms were tested in vitro. Histological evaluation showed SAON lesions in steroid treated groups. Mg and VC supplementation synergistically reduced the apoptosis of osteocytes and osteoclast number, and increased osteoblast surface. VC supplementation significantly increased the bone formation marker PINP, and the combination significantly decreased the bone resorption marker CTX. TNFα expression and oxidative injury were decreased in bone marrow in Mg/VC/combination group. Mg significantly increased the blood perfusion in proximal tibia and decreased the leakage particles in distal tibia 2 weeks after SAON induction. VC significantly elevated the osteoblast differentiation potential of marrow cells and improved the trabecular architecture. The combination supplementation significantly inhibited osteoclast differentiation potential of marrow cells. In vitro study showed promoting osteoblast differentiation effect of VC, and antiinflammation and promoting angiogenesis effect of Mg with underlying mechanisms. Mg and VC supplementation could synergistically alleviate SAON in rats, indicating great translational potentials of metallic minerals for preventing SAON.

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“…Scurvy is a clinical diagnosis with features that may include bleeding and swollen gums, loosening of teeth, bone abnormalities, arthralgia, delayed wound healing, anaemia and classic skin findings of perifollicular hyperkeratosis, petechiae and purpura. Fever can occur in the later stages of the disease …”

Section: Discussionmentioning

confidence: 99%