Dietary polyphenol impact on gut health and microbiota

Wan, Murphy Lam Yim; Co, Vanessa Anna; El‐Nezami, Hani

doi:10.1080/10408398.2020.1744512

Cited by 174 publications

(116 citation statements)

References 182 publications

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“…In fact, the microbiota's shift can directly affect the vital functions of the organism (Järbrink-Sehgal and Andreasson 2020; Wan et al 2020;Wang et al 2020). In this study, we observed an increase in the strains producing SCFA, including Prevotella, Alloprevotella, Lactobacillus, Ruminococcaceae, Blautia as a result of the application of the (MMGPE).…”

Section: Discussionsupporting

confidence: 51%

The combination of mare's milk and grape polyphenol extract for treatment of dysbiosis induced by dextran sulfate sodium

et al. 2020

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Abstract. Kozhakhmetov S, Babenko D, Nurgaziyev M, Tuyakova A, Nurgozhina A, Muhanbetganov N, Chulenbayeva L, Sergazy S, Gulyayev A, Saliev T, Kushugulova A. 2020. The combination of mare's milk and grape polyphenol extract for treatment of dysbiosis induced by dextran sulfate sodium. Biodiversitas 21: 2275-2280. This study showed the potential of a biological product based on mare's milk and a complex of grape polyphenols to modulate intestinal microflora after dextran sulfate sodium (DSS)-induced dysbiosis. Rat ulcerative colitis has been developed using intra-gastric administration of 10% DSS solution. To track changes in the structure of the microbiome at all stages of the study, the next-generation sequencing of the 16S rRNA gene section and LotuS conveyor were used. The results of sequencing demonstrated a decrease in biological diversity of microbiota after the induction of colitis, and recovery after 7 days of use of the (MMGPE). The product induced the structural changes of the microbiome damaged by DSS. Representatives of SCFA producing bacteria increased concentrations of Prevotella, Alloprevotella, Lactobacillus, Ruminococcaceae, and Blautia.

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Section: Discussionsupporting

confidence: 51%

The combination of mare's milk and grape polyphenol extract for treatment of dysbiosis induced by dextran sulfate sodium

et al. 2020

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“…Some of the positive effects in which the MeD is involved, regard the intake of phytochemical compounds present in vegetable foods, such as antioxidants [ 42 , 43 ]. They are metabolized by the intestinal microbiota and are thought to modulate the gut barrier function and immune response, helping to build strength against pathogenic microbes [ 44 – 46 ]. Some of the important molecules for their antioxidant action are: glutathione, ascorbic acid, vitamins A, D, E, polyphenols, omega-3, zinc, selenium, amino acids [ 47 ].…”

Section: Lifestyle and Gluten-free Dietary Advicementioning

confidence: 99%

How to manage celiac disease and gluten-free diet during the COVID-19 era: proposals from a tertiary referral center in a high-incidence scenario

et al. 2020

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The outbreak of COVID-19 and SARS-CoV-2 infection is spreading worldwide as the first coronavirus pandemic. The clinical picture is variable but flu-like symptoms are common with bilateral interstitial pneumonia being the most frightening presentation. No specific therapies nor vaccine have been developed to date and the only way to limit the virus diffusion is by modifying one’s lifestyle limiting social life and following strict hygienic precautions. No data is available on the risk of COVID-19 and its outcomes in celiac disease (CeD). The restrictions applied to counter COVID-19 can impact on CeD treatment and gluten-free dieting, the only available therapy for CeD. With the present manuscript, we aim to support gastroenterologists and nutritionists in the management of CeD patients in the new pandemic scenario, being conscious that availability and local situations are extremely various.

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“…31,32 In addition, after an HFD induces harmful bacteria, it will further negatively affect the intestinal epithelial cells or trigger the pro- Accumulating evidence shows that restricting dietary intake can modulate the gut microbiota and inhibit obesity and its associated diseases. 34 Cani et al 29 to activate TLR4 and producing a strong response to inflammation.…”

Section: Discussionmentioning

confidence: 99%

Spirulina platensis alleviates chronic inflammation with modulation of gut microbiota and intestinal permeability in rats fed a high‐fat diet

Wang

Chen

et al. 2020

J Cellular Molecular Medi

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Recent research suggested that taking a high‐fat diet (HFD) may lead to a gut microbiota imbalance and colon tissue damage. This would lead to increased intestinal permeability and consequent constant circulation of low‐grade inflammatory cytokines. Spirulina platensis can protect against HFD‐induced metabolic inflammation and can stimulate the growth of beneficial bacteria in in vitro stool cultures. However, it is unknown whether this beneficial effect acts on intestinal tissues. In this study, rats were fed a high‐fat diet fed with 3% S platensis for 14 weeks. We analysed endotoxin, the composition of the microbiota, inflammation and gut permeability. We found that S platensis decreased the bodyweight and visceral fat pads weight of the HFD‐fed rats. In addition, it lowered the levels of lipopolysaccharide and pro‐inflammatory cytokines in serum. Our results showed that S platensis could largely reduce the relative amount of Proteobacteria and the Firmicutes/Bacteroidetes ratio in faecal samples from HFD‐fed rats. S platensis significantly reduced intestinal inflammation, as shown by decreased expression of myeloid differentiation factor 88 (MyD88), toll‐like receptor 4 (TLR4), NF‐κB (p65) and inflammatory cytokines. S platensis also ameliorated the increased permeability and decreased expression of tight junction proteins in the intestinal mucosa, such as ZO‐1, Occludin and Claudin‐1. Therefore, in HFD‐induced gut dysbiosis rats, S platensis benefits health by inhibiting chronic inflammation and gut dysbiosis, and modulating gut permeability.

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Dietary polyphenol impact on gut health and microbiota

Cited by 174 publications

References 182 publications

The combination of mare's milk and grape polyphenol extract for treatment of dysbiosis induced by dextran sulfate sodium

The combination of mare's milk and grape polyphenol extract for treatment of dysbiosis induced by dextran sulfate sodium

How to manage celiac disease and gluten-free diet during the COVID-19 era: proposals from a tertiary referral center in a high-incidence scenario

Spirulina platensis alleviates chronic inflammation with modulation of gut microbiota and intestinal permeability in rats fed a high‐fat diet

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