The combination of mare's milk and grape polyphenol extract for treatment of dysbiosis induced by dextran sulfate sodium

Kozhakhmetov, Samat; Babenko, Dmitriy; Nurgaziyev, Madiyar; Tuyakova, Altynay; Nurgozhina, Ayaulym; Muhanbetganov, Nurislam; Chulenbayeva, Laura; Sergazy, Shynggys; Gulyaev, A. E.; Saliev, Timur; Kushugulova, Аlmagul

doi:10.13057/biodiv/d210558

Cited by 3 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current findings of the beneficial effects of mare's milk on the intestinal microbiota are supported by previously published studies that showed a significant association between mare's milk and the actions of intestinal microflora [ 23 ]. Interestingly, animal treatment with SP alone for 7 days restored the microflora levels of Lactobacillus population to that of the HC group, which shows that SP has much broader activity in restoring a wider range of microbiota than the positive control 5-ASA.…”

Section: Discussionsupporting

confidence: 85%

Therapeutic Potential of Metabolites from Lactobacillus rhamnosus and Mare’s Milk in the Treatment of Dysbiosis

Kozhakhmetov

Babenko²,

Kozhakhmetova

et al. 2022

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Ulcerative colitis is an inflammatory bowel disease that forms ulcerations in the mucous membrane of the colon and rectum, in which gut microbiota plays a pivotal role in its pathogenesis. Agents modulating microbial dysbiosis caused by colitis can help in the remission of this disease. The current study describes the potential therapeutic effects of active metabolites from Lactobacillus rhamnosus and mare’s milk which have potential therapeutic values on the intestinal microbiota and proinflammatory cytokines. The analysis of the V1-V3 16S rDNA site revealed significant changes in the intestinal microbiome composition before and after treatment in the treated group compared to the positive control group that was treated with 5-aminosalicylic acid (5-ASA). So the effect of the study product on dextran sulfate sodium-induced dysbiosis was shown to be more potent than the positive control, 5-ASA. The level of proinflammatory cytokines also decreased under the influence of a biological product.

show abstract

Section: Discussionsupporting

confidence: 85%

Therapeutic Potential of Metabolites from Lactobacillus rhamnosus and Mare’s Milk in the Treatment of Dysbiosis

Kozhakhmetov

Babenko²,

Kozhakhmetova

et al. 2022

BioMed Research International

Self Cite

View full text Add to dashboard Cite

show abstract

“…Considering the role of the gut–liver axis in the development of liver fibrosis and the importance of gut microbiota homeostasis [ [29] , [30] , [31] ], we speculate that lingonberry; cranberry and blueberry extracts may achieve their anti-fibrotic activity by improving and maintaining the integrity of intestinal epithelial, and gut microbiota. Previously, we showed that plant polyphenols can significantly influence and change intestinal microbiota [ 32 ]. Nevertheless, further research is needed to decipher the exact protective mechanism of blueberry and cranberry extracts against CCl4-induced liver damage.…”

Section: Discussionmentioning

confidence: 99%

Blueberry and cranberry extracts mitigate CCL4-induced liver damage, suppressing liver fibrosis, inflammation and oxidative stress

Sergazy¹,

Shulgau²,

Kamyshanskiy³

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…They prefer oligosaccharides to be consumed and have immunomodulatory effects (Ding et al 2017;Kusharyati et al 2020). Mare's milk also contains biologically active compounds; lysozyme; lactoferrin; the vitamins A, B1, B2, B6, B9, B12, and C; and the trace elements Na, Ca, K, P, Fe, Mg, Cu, I, S, Si, Zn, and C (Kozhakhmetov et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy

et al. 2020

Self Cite

View full text Add to dashboard Cite

Abstract. Nurgaziyev M, Atenov Y, Khassenbekova Z, Akpanova S, Rysbekov K, Kozhakhmetov S, Nurgozhina A, Sergazy S, Chulenbayeva L, Ospanova Z, Tuyakova A, Mukhambetganov N, Sattybayeva R, Urazova S, Galymgozhina N, Zhumadilova A, Gulyaev A, Kushugulova A. 2020. Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy. Biodiversitas 21: 5065-5071. Antibiotic treatment can severely affect the gut microbiome for short-term and long-term consequences. Probiotic and prebiotic supplements are widely prescribed to modulate the composition and function of the human gut microbiome. The current study aims to determine the impacts of mare’s milk prebiotics on the diversity of gut bacterial communities and the local immune system when administered during and after a course of antibiotic therapy. Six children aged 4 to 5 years diagnosed with bilateral bronchopneumonia were prescribed cephalosporin (cefuroxime) antibiotics. During the 60 days of the study, three children consumed mare’s milk prebiotics, while the other three did not. Fecal samples were collected daily during antibiotic therapy and every five days after the last day of antibiotic treatment. Total DNA was isolated, and the taxonomic composition of the gut microbiome was analyzed by sequencing the 16S rRNA gene (V1-V3 region). The MULTIPLEX MAP platform was used to evaluate the local immune status. The relative abundance of 11 genera was reduced and did not recover until the last day of the study. The abundance of Bacteroides was not significantly altered in either group. Christensenella, Rothia, Abiotrophia, Acinetobacter, Anaerotruncus, Holdemania, and Turicibacter numbers were significantly increased on day five and remained at the same level during the study period. Cephalosporin administration also reduced the levels of pro-inflammatory and anti-inflammatory cytokines/chemokines (MIP1α, TNFα, GMCSF, GCSF, sCD40L, FGF2, TGFα, IL1α, and IP10).

show abstract

The combination of mare's milk and grape polyphenol extract for treatment of dysbiosis induced by dextran sulfate sodium

Cited by 3 publications

References 24 publications

Therapeutic Potential of Metabolites from Lactobacillus rhamnosus and Mare’s Milk in the Treatment of Dysbiosis

Therapeutic Potential of Metabolites from Lactobacillus rhamnosus and Mare’s Milk in the Treatment of Dysbiosis

Blueberry and cranberry extracts mitigate CCL4-induced liver damage, suppressing liver fibrosis, inflammation and oxidative stress

Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy

Contact Info

Product

Resources

About