Dietary patterns interact with chromosome 9p21 rs1333048 polymorphism on the risk of obesity and cardiovascular risk factors in apparently healthy Tehrani adults

Mollahosseini, Mehdi; Rahimi, Mohammad; Yekaninejad, Mir Saeed; Maghbooli, Zhila; Mirzaei, Khadijeh

doi:10.1007/s00394-018-1872-1

Cited by 15 publications

(13 citation statements)

References 47 publications

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“…Therefore, the analysis of dietary patterns has been identified as a more realistic representation of dietary habits, since it takes into account the complex interactions between nutrients and other components of a diet, thus making interventions to change eating habits possible [44,45]. Studies on the association and interaction between SNPs and nutrient intake or dietary patterns on obesity risk factors have also made some progress [46,47], which can well find the relationship between the three, laying the foundation for further research. In our study, four dietary patterns of male children were identified, of which NSDP was related to higher FBG levels and AFDP was associated with higher levels of LDL.…”

Section: Discussionmentioning

confidence: 99%

Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children

Zhu

Xue

Guo

et al. 2020

IJERPH

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A genome-wide association study (GWAS) in the Han Chinese population had found that single nucleotide polymorphism (SNP) on the CMTM7 gene rs347134 was significantly associated with Body Mass Index (BMI). In the present study, the association of the rs347134 SNP with obesity and its interaction with dietary patterns (DPs) were explored in Han Chinese children. This cross-sectional study group included 1292 children, in whom obesity-related indicators were evaluated, the rs347134 SNP was genotyped by improved Multiple Ligase Detection Reaction (iMLDR), and the DPs were identified by principal component factor analysis. The GG genotype exhibited higher odds of general overweight/obesity (P = 0.038) and central obesity (P = 0.039) than AA + GA genotypes in boys. Four DPs of boys were identified: healthy balanced (HBDP), nuts and sweets-based (NSDP), animal food-based (AFDP), and wheaten and dairy-based (WDDP). Boys with the GG genotype were significantly more inclined to AFDP (P = 0.028) and had a shorter sleep duration (P = 0.031). Significant interactions were observed; boys with the GG genotype displayed a higher LDL in AFDP (P = 0.031) and higher FBG in NSDP (P = 0.038), respectively. Our findings indicate for the first time that the GG genotype of CMTM7 rs347134 is potentially a novel obesity risk factor for Han Chinese male children and is associated with dietary patterns more or less.

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Section: Discussionmentioning

confidence: 99%

Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children

Zhu

Xue

Guo

et al. 2020

IJERPH

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“…The diet scores were estimated using a semi-quantitative FFQ including a list of 147 food items this questionnaire has well-established reliability and validity speci cally for Iranian adults. [15,16], Domestic measurements and servings underwent conversion into weight (g day − 1 ), followed by converting food items to 18 food groups to extract dietetic models [17].…”

Section: Dietary Assessmentmentioning

confidence: 99%

Interactions between Caveolin 1 polymorphism and the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) diet on Metabolic dyslipidemia in overweight and obese adult women: a cross-sectional study

Khatibi

Mirzababaei

Shiraseb

et al. 2021

Preprint

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Objective: A higher incidence of metabolic dyslipidemia (MD) and its association with many diseases attracted considerable attention to its control. Caveolin 1 (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND( is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients.Results: Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β=-0.25±132, P=0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to MIND diet may exhibit the lower dyslipidemia.This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.

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“…Unlike general obesity, defined as elevated total body adiposity irrespective of its distribution, central obesity represent a high level of abdominal or visceral fat, which is a stronger predictor of obesity-related diseases [ 7 ]. Obesity is a multifactorial phenomenon, resulting from an interaction between genetic variants and environmental factors, including diet, physical inactivity, low sleep quality, obesogens, and even the diversity and composition of gut microbiota [ 8 , 9 ]. Also, a low basal metabolic rate (BMR), as a leading component of total daily energy expenditure, is one of the main metabolic predictors for the development of body weight gain [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Interaction of MC4R rs17782313 variants and dietary carbohydrate quantity and quality on basal metabolic rate and general and central obesity in overweight/obese women: a cross-sectional study

et al. 2022

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Background Recent studies have shown that dietary carbohydrate quantity and quality as well as genetic variants may contribute to determining the metabolic rate and general and central obesity. This study aimed to examine interactions between melanocortin 4 receptor gene (MC4R) rs17782313 and dietary carbohydrate intake, glycemic index (GI), and glycemic load (GL) on body mass index (BMI), waist circumferences (WC), basal metabolic rate (BMR), and BMR/kg in overweight/obese women. Methods A total of 282 Iranian women (BMI ≥ 25) aged 18–56 years were enrolled in this cross-sectional study. All participants were assessed for blood parameters, body composition, BMR, and dietary intake. Dietary carbohydrate intake, GI, and GL were determined using a valid, reliable 147-item food frequency questionnaire. MC4R rs17782313 was genotyped by the restriction fragment length polymorphism (PCR-RFLP) method. Results After adjustment for age and energy intake, significant interactions were observed between carbohydrate intake and MC4R rs17782313 in terms of BMI (P Interaction = 0.007), WC (P Interaction = 0.02), and BMR/kg (P Interaction = 0.003) in this way that higher carbohydrate intake, compared with lower intake, was associated with an increase in BMI and WC for individuals with C allele carriers (TC + CC genotypes), while related to an increase in BMR/kg for those carrying the TT genotype. No significant interaction was found between MC4R rs17782313 and GI and GL on BMI, WC, BMR/kg, and BMR. Conclusions Interactions between the MC4R rs17782313 and carbohydrate intake probably can have an effect on BMI, WC, and BMR/kg in overweight/obese women.

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Dietary patterns interact with chromosome 9p21 rs1333048 polymorphism on the risk of obesity and cardiovascular risk factors in apparently healthy Tehrani adults

Cited by 15 publications

References 47 publications

Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children

Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children

Interactions between Caveolin 1 polymorphism and the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) diet on Metabolic dyslipidemia in overweight and obese adult women: a cross-sectional study

Interaction of MC4R rs17782313 variants and dietary carbohydrate quantity and quality on basal metabolic rate and general and central obesity in overweight/obese women: a cross-sectional study

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