Dietary Omega-3 Lipids Delay the Onset and Progression of Autoimmune Lupus Nephritis by Inhibiting Transforming Growth Factor β mRNA and Protein Expression

Chandrasekar, Bysani; Troyer, Dean A.; Venkatraman, Jaya T.; Fernandes, Gabriel

doi:10.1006/jaut.1995.0030

Cited by 77 publications

(43 citation statements)

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“…Therefore, plasma levels of PDGF would fall following ®sh oil supplementation without a concomitant fall in serum PDGF levels. Fish oil-enriched diets have previously been reported to reduce tissue TGFb mRNA expression in speci®c animal models of disease (Chandrasekar et al, 1995). However, our ®nding of no effect of n-3 fatty acid supplementation on TGFb is in keeping with an earlier study which reported that dietary n-3 fatty acids did not alter TGFb mRNA expression in mononuclear cells .…”

Section: Discussionsupporting

confidence: 90%

The effect of low-dose fish oil supplementation on serum growth factors in healthy humans

et al. 2000

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Objective: To examine the effect of low-dose ®sh oil supplementation on speci®c growth factors, purported to play a central role in lesion formation, and also on the total growth factor activity of serum, as assessed by the induction of DNA synthesis in cultured human arterial smooth muscle cells. Design: Randomized placebo-controlled double-blind intervention study. Setting: Free-living population. Subjects: Sixty-three healthy volunteers, 37 males and 26 females. Interventions: Four treatment regimes with subjects receiving 0, 0.3,0.6 or 0.9 gaday of n-3 PUFA for an 8 week period. Blood samples were taken at baseline and following the 8 week intervention. All samples were analysed in batch following completion of the study. Results: Consumption of ®sh oil had no effect on serum platelet-derived growth factor (PDGF), or transforming growth factor beta (TGFb) concentration. Furthermore, ®sh oil supplementation did not alter the total growth factor activity of serum. Conclusions: Results indicate that low-dose ®sh oil supplementation, equivalent to about two portions of fatty ®sh per week and providing less than 1 g n-3 PUFAaday, does not alter the levels of the major serum growth factors and does not modify total serum growth factor activity in healthy human volunteers. Sponsorship: European Union shared cost project (FAIR-CT-95-0085).

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Section: Discussionsupporting

confidence: 90%

The effect of low-dose fish oil supplementation on serum growth factors in healthy humans

et al. 2000

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“…These cytokines stimulate production of PGs, and it is interesting to speculate that feeding fish oil fats ameliorates renal disease in short-lived B/W mice by both suppressing pro-inflammatory cytokine production and altering the profile of prostaglandins produced upon stimulation by way of substituting EPA and DHA for arachidonic acid in membrane phospholipids. In additional studies we have shown that at 6.5 months of age, kidney tissue from fish oil fed B/W mice also had reduced TGFI31 mRNA and protein levels compared to corn oil fed animals (62). The alteration of cytokine production by fish oil supplementation is organ specific.…”

Section: Fish Oil Fats and Autoimmune Disease In The Short-lived B/w mentioning

confidence: 82%

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

Troyer

Venkatraman

Fernandes

1998

AGE

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Aging is accompanied by a steady increase in the incidence of spontaneous tumors and a decline in immune function. Calorie restriction (CR) or supplementation with (0-3 fats prolongs life span, suppresses tumorigenesis, and ameliorates immune function in a variety of experimental models. We suggest that decreased oxidant stress and upregulation of apoptosis mediate the effects of calorie restriction on immunity and longevity. CR prolongs life span in several animal models and our studies have examined the effects of CR on the immune system and on tumorigenesis.

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“…CR has also been found to maintain naive T cells and prevent the rise of memory T cells with age in both short-and long-lived strains of mice and rats (Fernandes et al, 1994(Fernandes et al, , 1997Reddy et al, 1999). Earlier we reported that CR decreased the expression of mRNA coding for pro-inflammatory cytokines and increased the expression of mRNA coding for anti-inflammatory cytokines, including transforming growth factor beta (TGF␤), in B/W mice (Chandrasekar et al, 1995b). Further CR was also found to decrease free radical generation by increasing antioxidant enzyme activities (Byun et al, 1995;Fernandes et al, 1995;Semsei et al, 1989;Venkatraman et al, 1998).…”

Section: Introductionmentioning

confidence: 90%

“…Increased life span in CR fed mice was mainly due to a delay in the onset of lifeshortening diseases such as malignancy and kidney disease in mice and rats (Chandrasekar et al, 1995a;Fernandes et al, 1976Fernandes et al, , 1994Fernandes et al, , 1995. In the case of autoimmune-prone mice, CR is found to delay the early loss of T-cell immune function and to decrease the formation of immune complexes in the kidneys (Chandrasekar et al, 1995b;Fernandes et al, 1995). CR has also been found to maintain naive T cells and prevent the rise of memory T cells with age in both short-and long-lived strains of mice and rats (Fernandes et al, 1994(Fernandes et al, , 1997Reddy et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of H₂O₂‐induced apoptosis of lymphocytes by calorie restriction during aging

Avula

Fernandes

2002

Microscopy Res & Technique

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Calorie restriction (CR) is known to delay the aging process in rodents and is postulated to act by decreasing free radical generation and increasing antioxidant enzyme activity. The present study was designed to investigate the effect of CR and age on oxidative stress-induced apoptosis and associated changes in the levels of TNF-alpha, and Bcl-2 in splenic T lymphocytes. Ad libitum (AL)- or CR-fed C57BL/6J mice were sacrificed either at 6 (young) or 18 (old) months and splenic lymphocytes were incubated with or without 25 micro M H2O2 to induce apoptosis. Apoptosis increased with age in cells of AL-fed mice incubated with H2O2. CR prevented this rise in apoptosis in total splenic lymphocytes and in CD4(+) and CD8(+) T lymphocyte subsets either with or without H2O2. Free radicals increased and mitochondrial membrane potential decreased in aged mice. CR prevented these changes and also prevented the age-associated increase in TNF-alpha and loss of Bcl-2 in total splenic lymphocytes and in CD4(+) and CD8(+) lymphocyte subsets. In summary, lymphocytes in aged AL-fed mice were much more susceptible to oxidative stress-induced apoptosis whereas CR normalized apoptosis by preventing the increase in TNF-alpha and the decrease in Bcl-2 associated with aging.

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Dietary Omega-3 Lipids Delay the Onset and Progression of Autoimmune Lupus Nephritis by Inhibiting Transforming Growth Factor β mRNA and Protein Expression

Cited by 77 publications

References 0 publications

The effect of low-dose fish oil supplementation on serum growth factors in healthy humans

The effect of low-dose fish oil supplementation on serum growth factors in healthy humans

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

Inhibition of H₂O₂‐induced apoptosis of lymphocytes by calorie restriction during aging

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Dietary Omega-3 Lipids Delay the Onset and Progression of Autoimmune Lupus Nephritis by Inhibiting Transforming Growth Factor β mRNA and Protein Expression

Cited by 77 publications

References 0 publications

The effect of low-dose fish oil supplementation on serum growth factors in healthy humans

The effect of low-dose fish oil supplementation on serum growth factors in healthy humans

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

Inhibition of H2O2‐induced apoptosis of lymphocytes by calorie restriction during aging

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Inhibition of H₂O₂‐induced apoptosis of lymphocytes by calorie restriction during aging