The effect of low-dose fish oil supplementation on serum growth factors in healthy humans

Wallace, Julie; McCabe, Anthony; Roche, Helen M.; Higgins, S.; Robson, Paula J.; Gilmore, William S.; McGlynn, Hugh; Strain, J. J.

doi:10.1038/sj.ejcn.1601076

Cited by 8 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PDGF concentrations in plasma in our study were reduced by consumption of 3.4g/d of EPA+DHA. This is in contrast to the results of an earlier study of 63 healthy participants in which the consumption of 0.3, 0.6 or 0.9 g/day of EPA+DHA for 8 weeks had no effect on serum PDGF levels[9]. A dose of 0.6 mg/day is consistent with slightly more than 2 portions of fatty fish per week, and 1 g/day is consistent with about 4 fatty fish meals per week.…”

Section: Discussioncontrasting

confidence: 98%

The effects of EPA + DHA and aspirin on inflammatory cytokines and angiogenesis factors

Block¹,

Dier²,

CalderonArtero³

et al. 2012

WJCD

View full text Add to dashboard Cite

Objective In a recent study, we showed that the combination of aspirin plus the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) synergistically inhibited platelet function. As aspirin, EPA, and DHA have demonstrated anti-inflammatory properties, we hypothesized that the ingestion of EPA and DHA, with and without aspirin, would reduce plasma levels of inflammatory cytokines and angiogenesis factors more than aspirin alone and before aspirin was ingested. Methods Using multiplex technology, we investigated the effects of aspirin (single-dose 650 mg on day 1), EPA+DHA (3.4 g/d for days 2-29), and aspirin with EPA+DHA (day 30) on plasma levels of inflammatory cytokines and angiogenesis factors in healthy adults. Results Aspirin alone had no effect on any factor versus baseline, but EPA+DHA, with and without aspirin, significantly reduced concentrations of 8 of 9 factors. Although EPA+DHA plus aspirin reduced concentrations of a subset of the factors compared to baseline, neither aspirin alone nor the combination significantly reduced the level of any analyte more robustly than EPA+DHA alone. Conclusions These data suggest that EPA+DHA has more pronounced down-regulatory effects on inflammation and angiogenesis than aspirin. The implications of these findings for the use of combined therapy for cardiovascular disease remain to be clarified.

show abstract

Section: Discussioncontrasting

confidence: 98%

The effects of EPA + DHA and aspirin on inflammatory cytokines and angiogenesis factors

Block¹,

Dier²,

CalderonArtero³

et al. 2012

WJCD

View full text Add to dashboard Cite

show abstract

“…Consistent with these reports, several clinical studies have shown that consumption of n-3 PUFA-rich fish oil leads to the down-regulation of proinflammatory cytokines and the upregulation of antiinflammatory mediators and has benefits in RA prevention and treatment [11,12]. However, some human studies have reported controversial results [13][14][15].…”

Section: Introductionmentioning

confidence: 80%

Endogenous conversion of n-6 to n-3 polyunsaturated fatty acids attenuates K/BxN serum-transfer arthritis in fat-1 mice

Woo

Lim

Park

et al. 2015

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…In addition, it has been shown that n-3 PUFAs down-regulate pro-inflammatory cytokines and up-regulated anti-inflammatory mediators in RA [ 17 , 26 ]. However, other studies reported controversial results [ 27 , 28 ]. Therefore, the efficacy of n-3 PUFA on RA has not been clarified yet.…”

Section: Discussionmentioning

confidence: 99%

N-3 polyunsaturated fatty acids restore Th17 and Treg balance in collagen antibody-induced arthritis

et al. 2018

View full text Add to dashboard Cite

N-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and were considered useful for the treatment of rheumatoid arthritis (RA). Recently, several studies suggested that n-3 PUFAs attenuated arthritis in animal model and human, however the mechanism is still unclear. Interleukin 17 (IL-17) is a pro-inflammatory cytokine mainly produced by T helper 17 (Th17) cells which cause tissue inflammation and bone erosion leading to joint destruction. In contrast, regulatory T (Treg) cells down-regulate various immune responses by suppression of naïve T cells. The imbalance between Th17 cells and Tregs cell is important for the pathogenesis of RA. Here, we investigated whether n-3 PUFAs attenuate arthritis in collagen antibody-induced arthritis (CAIA) model. We used fat-1 transgenic mice expressing the Caenorhabditis elegans fat-1 gene encoding an n-3 fatty acid desaturase that converts n-6 to n-3 fatty acids, leading to abundant n-3 fatty acids without the need of a dietary n-3 supply. Clinical arthritis score was significantly attenuated in fat-1 mice compared to wild type (WT) mice on day 7 (1.6±1.8, p = 0.012) and day 9 (1.5±1.6, p = 0.003). Ankle thickness also decreased significantly in fat-1 mice compared to WT mice (1.82±0.11, p = 0.008). The pathologic finding showed that inflammatory cell infiltration and bone destruction were reduced in fat-1 mice compared to WT. The expression levels of IL-17 and related cytokines including IL-6 and IL-23 decreased in the spleen and ankle joint tissue of fat-1 mice compared to WT mice. Furthermore, Treg cells were expanded in the spleen of fat-1 mice and Treg cell differentiation was significantly higher in fat-1 mice than in wild type (p = 0.038). These data suggest that n-3 PUFAs could attenuate arthritis through increasing the expression of FoxP3 and the differentiation of Treg, while reducing IL-17 production. Therefore, dietary supplementation of n-3 PUFAs could have a therapeutic potential for the treatment of RA.

show abstract

The effect of low-dose fish oil supplementation on serum growth factors in healthy humans

Cited by 8 publications

References 26 publications

The effects of EPA + DHA and aspirin on inflammatory cytokines and angiogenesis factors

The effects of EPA + DHA and aspirin on inflammatory cytokines and angiogenesis factors

Endogenous conversion of n-6 to n-3 polyunsaturated fatty acids attenuates K/BxN serum-transfer arthritis in fat-1 mice

N-3 polyunsaturated fatty acids restore Th17 and Treg balance in collagen antibody-induced arthritis

Contact Info

Product

Resources

About