Dietary N-nitroso compounds, endogenous nitrosation, and the risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study

Keszei, András; Goldbohm, R. Alexandra; Schouten, Leo J.; Jakszyn, Paula; Brandt, Piet A. van den

doi:10.3945/ajcn.112.043885

Cited by 138 publications

(111 citation statements)

References 43 publications

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“…Gastric cancer is a progressive disease. Surgical resection is the only potential curative treatment, however despite the adjuvant or neoadjuvant chemotherapy/chemoradiotherapy administered on patients, the disease recurs in majority of the patients (Cunningham et al, 2006 dietary N-nitroso compounds and endogenous nitrosation (Keszei et al, 2013;Li et al, 2013;Pohl et al, 2013). Determination of primary prevention and risk factors is important for such diseases with bad prognosis and fast progression.…”

Section: Introductionmentioning

confidence: 99%

Esophageal Cancer, Gastric Cancer and the use of Pesticides in the Southwestern of Turkey

Yıldırım¹,

Kaya²,

Yıldız³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

Esophageal Cancer, Gastric Cancer and the use of Pesticides in the Southwestern of Turkey

Yıldırım¹,

Kaya²,

Yıldız³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…NDMA, nitrite, and heme iron intake was measured using questionnaire data as described previously (6).…”

Section: Methodsmentioning

confidence: 99%

Meat Consumption and the Risk of Barrett's Esophagus in a Large Dutch Cohort

Keszei

Schouten

Driessen

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Increasing meat intake and its possible role in the development of esophageal adenocarcinoma raises the question whether meat consumption is associated with the premalignant lesion, Barrett's esophagus.Methods: Associations between the risk of Barrett's esophagus and meat consumption, intake of Nnitrosodimethylamine, nitrite, and heme iron were examined in the Netherlands Cohort Study among 120,852 subjects aged 55 to 69 years in 1986. Exposure was measured on the basis of a 150-item food frequency questionnaire. After 16.3 years of follow-up, 447 Barrett's esophagus cases with specialized intestinal metaplasia and 3,919 subcohort members were analyzed in a case-cohort design.Results: There was no association of any of the examined exposures with Barrett's risk in men or women. Results were similar in age-adjusted and fully adjusted models and in models excluding the first two years of follow-up.Conclusions: Our results do not support a role of meat consumption and N-nitrosation related factors in the development of Barrett's esophagus.Impact: The possible causal association between red meat intake and esophageal adenocarcinoma is unlikely to be mediated by mechanisms through the development of Barrett's esophagus. Cancer Epidemiol Biomarkers Prev; 22(6); 1162-6. Ó2013 AACR.

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“…Almost all Nnitroso compounds tested have been shown to have carcinogenic activity in experimental animals (13), and thus exposure to N-nitroso compounds is suspected to correlate with the induction of human cancer. Moreover, the endogenous formation of N-nitroso compounds is reported to relate with cancer induction in epidemiological study (10,(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Antimutagenicity Screening of Extracts from Medicinal and Edible Plants against N-Methyl-N-nitrosourea by the Ames Assay

Tatsuzaki¹,

Yang²,

Kojo

et al. 2014

Genes and Environment

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N-Nitroso compounds are suspected to be causative agents for human cancer. N-Methyl-N-nitrosourea (MNU) is a typical direct acting mutagen with alkylation activity of DNA, and has been reported to be formed in vivo. Therefore, it is important for cancer chemoprevention toˆnd some compounds to inhibit mutagenicity induced by MNU. The inhibitory eŠect of plant extracts against the mutagenicity of MNU was evaluated using the Ames assay with Salmonella typhimurium TA1535. Among 43 extracts derived from medicinal and edible plant assayed, Glycyrrhiza aspera ethanolic extract, Glycine max extract with 40% iso‰avone aglycone (ISOMAX AG40) and Zingiber o‹cinale ethanolic extract at the range 0.01-1.0 mg/plate inhibited MNU-induced mutagenicity in S. typhimurium TA1535. No cytotoxicity of the three extracts were observed in Salmonella typhimuirum TA1535, indicating that inhibition of MNU-induced mutagenicity was apparently due to the antimutagenic potency of Glycyrrhiza aspera ethanolic extract, ISOMAX AG40 and Zingiber o‹cinale ethanolic extract. Therefore, the results of relative mutagenicity showed that Glycyrrhiza aspera ethanolic extract and ISOMAX AG40 decreased the mutagenic eŠects to 5.4% and 2.6%, respectively, whereas Zingiber o‹cinale ethanolic extract decreased it to 45%.

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Dietary N-nitroso compounds, endogenous nitrosation, and the risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study

Abstract: These results suggest that N-nitroso compounds may influence the risk of ESCC in men, but there are no clear associations for other esophageal and gastric subtypes.

Cited by 138 publications

References 43 publications

Esophageal Cancer, Gastric Cancer and the use of Pesticides in the Southwestern of Turkey

Esophageal Cancer, Gastric Cancer and the use of Pesticides in the Southwestern of Turkey

Meat Consumption and the Risk of Barrett's Esophagus in a Large Dutch Cohort

Antimutagenicity Screening of Extracts from Medicinal and Edible Plants against N-Methyl-N-nitrosourea by the Ames Assay

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