Dietary isoflavones and gastric cancer: A brief review of current studies

Golpour, Sahar; Rafie, Nahid; Safavi, Sayyed Morteza; Miraghajani, Maryam

doi:10.4103/1735-1995.170627

Cited by 16 publications

(6 citation statements)

References 35 publications

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“…The morbidity of gastric cancer has increased with economic development and changes in dietary patterns[19-22]. Furthermore, Helicobacter pylori infection, gastric polyps, and gastritis can lead to gastric cancer[23-27].…”

Section: Discussionmentioning

confidence: 99%

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

Sheng¹,

Chen²,

Tu³

et al. 2016

WJG

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AIMTo explore expression of angiopoietin-like protein 2 (ANGPTL2) and its effect on biological behavior such as proliferation and invasiveness in gastric cancer.METHODSWestern blotting was used to detect expression of ANGPTL2 in 60 human normal gastric tissues, 60 human gastric cancer tissues and gastric cell lines including GES-1, N87, SGC7901, BGC823 and PAMC82. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Transwell assay were used to detect the proliferation and invasive ability of gastric cancer cells.RESULTSCompared to normal tissues, ANGPTL2 protein levels were significantly upregulated in gastric tissues, and this level was closely correlated with gastric tumor grade, clinical stage and lymph node metastasis. Compared to GES-1 cells, ANGPTL2 mRNA and protein levels were significantly increased in gastric cancer cells including N87, SGC7901, BGC823 and PAMC82. The expression of ANGPTL2 in highly malignant gastric cancer cell lines BGC823 and PAMC82 was significantly higher than in low malignancy gastric cancer cell lines N87 and SGC7901. MTT and Transwell experiments indicated that the proliferation rate and invasive ability of stable overexpressed gastric cancer cells was faster than in cells transfected with Lv-NC and blank control cells, and the invasive ability of stable overexpressed gastric cancer cells was higher than that of cells transfected with Lv-NC and blank control cells.CONCLUSIONANGPTL2 contributed to proliferation and invasion of gastric cancer cells. In clinical treatment, ANGPTL2 may become a new target for treatment of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

Sheng¹,

Chen²,

Tu³

et al. 2016

WJG

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“…[ 1 ] Diet modification is the most important preventive and treatment strategy against breast cancer. [ 2 3 4 5 6 ] Although dietary fat is associated with increased risk of mammary tumor, some types of fats such as omega-3 and conjugated linoleic acids (CLA) can have protective effects. [ 7 8 ]…”

Section: Introductionmentioning

confidence: 99%

The effects of conjugated linoleic acids on breast cancer: A systematic review

et al. 2016

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Recently prevention strategies for breast cancer are focused on lifestyle modification such as diet. Some dietary factors such as Conjugated linoleic acid (CLA) can lower the risk of breast cancer, metastasis and some factors concerning this malignancy. Many studies have been established in this field, but their results are inconsistent. Therefore, we evaluated this association based on systematic review among published scientific literature. We performed an electronic search using PubMed, Cochrane, Scopus, Google Scholar and Persian database (Iran Medex, magiran) to identify relevant studies. We summarized the findings of 8 papers in this review. Although, three cohort studies were not overall identified a protective effect of CLA dietary intake or CLA content in breast tissue on breast cancer incidence, metastasis and death, one of them showed an inverse association after adjusting for age. Also, among case-control studies a weak inverse association between breast cancer risk and CLA dietary intake and serum levels among post-menopausal women was reported. Besides, a clinical trial showed that some indicator of breast tumor decreased after CLA administration among women with breast adenocarcinoma. Lacking published evidence suggested inconsistent results. So, further well-designed studies are required, particularly in considering the main breast cancer risk factors.

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“…Gastric cancer is one of the most common human epithelial malignancies and remains the second leading cause of cancer-associated mortality for clinical cancer ( 1 ). Clinical statistics and investigations have shown that >70% of new cases of gastric cancer-associated deaths occur in developing countries ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Application of novel targeting nanoparticles contrast agent combined with contrast‑enhanced computed tomography during screening for early‑phase gastric carcinoma

Zhang

et al. 2017

Exp Ther Med

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Gastric cancer is one of the most common human tumors worldwide. The biggest bottleneck is a lack of advanced and sensitive protocols for the diagnosis of patients with early-stage gastric cancer. Therefore, more sensitive methods of diagnosing gastric cancer are urgently required to improve survival rates. In this clinical study, contrast-enhanced computed tomography (CECT) with targeting nanoparticles contrast agent (CECT-TNCA) was used to diagnose early-stage gastric cancer. The specific-targeted tyrosine kinase inhibitors of gastric cancer, including platelet-derived growth factor receptor-β, Ret and Kit, were used as TNCAs. A total of 484 patients with suspected gastric cancer were voluntarily recruited to investigate the efficacy of CECT-TNCA in the diagnosis of patients with early-stage gastric cancer. Patients with suspected gastric cancer were subjected CT and CECT-TNCA to detect whether gastric tumors existed. TNCA was orally administered before CT and CECT-TNCA (20 min). Our diagnostic data revealed that CECT-TNCA improved sensitivity and provided a new protocol to diagnose tumors in patients with suspected gastric cancer at the early stage. In addition, imaging using CECT-TNCA enabled the visualization of tiny nodules in the gastric area. CECT-TNCA diagnosed 182 patients with suspected gastric cancer as tumor-free. CECT-TNCA confirmed gastric cancer in 302 patients. Our novel diagnosis indicated significantly (P<0.01) differential signal enhancement in the gastric nodules via CECT-TNCA compared with CT, suggesting higher accuracy and the accumulation of TNCA in tumor nodules in the stomach. Furthermore, survival rates of patients detected by early-diagnosis of CECT-TNCA were significantly higher than the mean five-year survival (P<0.01). In conclusion, our investigations demonstrate that the sensibility and accuracy of CT is improved through combination with liposome-encapsulated nanoparticle contrast agent for the diagnosis of early stage gastric cancer when compared with single CT detection. CECT-TNCA improves the accuracy of CT and diagnostic confidence in assessing mural enhancement in patients with suspected gastric cancer.

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Dietary isoflavones and gastric cancer: A brief review of current studies

Cited by 16 publications

References 35 publications

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

The effects of conjugated linoleic acids on breast cancer: A systematic review

Application of novel targeting nanoparticles contrast agent combined with contrast‑enhanced computed tomography during screening for early‑phase gastric carcinoma

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