Application of novel targeting nanoparticles contrast agent combined with contrast‑enhanced computed tomography during screening for early‑phase gastric carcinoma

Zhang, Kaimin; Du, Xijian; Yu, Kai; Zhang, Kaiyu; Zhou, Yifang

doi:10.3892/etm.2017.5388

Cited by 8 publications

(9 citation statements)

References 46 publications

(41 reference statements)

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“…Here, we found that RET was significantly upregulated in GC tissues in relation to normal gastric mucosa, supporting the similar findings of Zhang et al, and their conclusion that RET overexpression may be one of the molecular changes driving gastric carcinogenesis 34 . This is additionally underpinned by the fact that the new diagnostic method developed by Zhang et al, based on contrast-enhanced computed tomography (CECT) combined with liposome-encapsulated targeted contrast agents containing tyrosine kinase inhibitors of GC, including RET, allowed for the effective diagnosis of patients in the early stage of gastric cancer 53 . To our knowledge, the cited study of Zhang et al is the only one existing in the scientific literature which assessed by IHC the expression level of RET protein in the series of GC tissues.…”

Section: Discussionmentioning

confidence: 99%

Expression of the Body-Weight Signaling Players: GDF15, GFRAL and RET and their clinical relevance in Gastric Cancer

Buchholz¹,

Antosik²,

Grzanka³

et al. 2021

J. Cancer

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The existence, the functional role and clinical relevance of GDF15 and its signaling through a GFRAL/RET-dependent complex in gastric cancer (GC) and other human tumors remain to be elucidated, despite the widespread recognition of obesity as an important cancer-predisposing factor. Therefore, we aimed to analyze the expression levels of GDF15, GFRAL and RET in GC tissues in relation to each other and clinicopathological features, including patient survival, in order to establish a potential implication of the body-weight signaling pathway in the pathology and clinical outcome of GC. Protein expression was examined by immunohistochemistry on tissue microarrays containing 104 and 30 consecutive GC and normal gastric mucosa samples, whereas gene expression data for The Cancer Genome Atlas cohort of 413 GC patients were obtained from public sources. We found that the protein expression of GDF15, GFRAL and RET was significantly elevated and positively correlated in our set of GC tissues, which was reflected in their tendency to be overexpressed in low-grade and intermediate-grade tumors rather than high-grade ones. No other relationships between the expression status of the examined proteins and clinicopathological characteristics of GC patients were found. Through in silico data analysis, we showed that high GDF15 expression was associated with better overall survival (OS) of GC patients, whereas the opposite was true for high levels of GFRAL or RET . Specifically, GFRAL and RET emerged as independent prognostic factors associated with poor OS. Furthermore, high combined expression of the three markers: GDF15+GFRAL+RET was significantly associated with reduced OS, and it was an independent prognostic factor of borderline significance in terms of OS, when adjusted for covariates. If validated in large-scale studies, the individual and combined expression of GDF1 5, GFRAL and RET may provide significant clinical implications for the prognosis prediction of GC patients.

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Section: Discussionmentioning

confidence: 99%

Expression of the Body-Weight Signaling Players: GDF15, GFRAL and RET and their clinical relevance in Gastric Cancer

Buchholz¹,

Antosik²,

Grzanka³

et al. 2021

J. Cancer

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“…Comparing various medical topics using liposomal delivery systems for imaging and therapy, oncology is the area with the biggest collection of data referring to its broad application. Liposome-nanoparticle hybrids that include metallic components such as: gold nanoparticles [75,81] or gadolinium nanoparticles (GdNPs) [63,82,83], and ultrasuperand superparamagnetic iron oxide nanoparticles (SPIONs)-called magnetoliposomes (MLs) [60,84,85]-can serve in the visualization of the cancer tissues using CT and MRI. Liposome-based CAs incorporating gadolinium were the first introduced nanostructure that has been widely used in various systems [86][87][88].…”

Section: Medical Imagingmentioning

confidence: 99%

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

Musielak

Potoczny

Boś-Liedke

et al. 2021

IJMS

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Nanotechnology has introduced a new quality and has definitely developed the possibilities of treating and diagnosing various diseases. One of the scientists’ interests is liposomes and metallic nanoparticles (LipoMNPs)—the combination of which has introduced new properties and applications. However, the field of creating hybrid nanostructures consisting of liposomes and metallic nanoparticles is relatively little understood. The purpose of this review was to compile the latest reports in the field of treatment and medical imaging using of LipoMNPs. The authors focused on presenting this issue in the direction of improving the used conventional treatment and imaging methods. Most of all, the nature of bio-interactions between nanostructures and cells is not sufficiently taken into account. As a result, overcoming the existing limitations in the implementation of such solutions in the clinic is difficult. We concluded that hybrid nanostructures are used in a very wide range, especially in the treatment of cancer and magnetic resonance imaging. There were also solutions that combine treatments with simultaneous imaging, creating a theragnostic approach. In the future, researchers should focus on the description of the biological interactions and the long-term effects of the nanostructures to use LipoMNPs in the treatment of patients.

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“…NVs can be conjugated with QDs to function as vehicles to transport specific therapeutic cargo (eg aptamer) to target GI premalignant lesions directly 19,56. A vesicle composite probe is constructed in multiple steps to carry a specific aptamer for direct detection of the lesion (Figure 2).…”

Section: Combined Targeting Of Nvs and Hif Against Gi Premalignant Lementioning

confidence: 99%

“…Localized surface plasmon resonance biosensors with self-assembled gold nanoislands (SAM-AuNIs) has been demonstrated to be another direct method for direct target detection and this method may be able to distinguish exosomes from different sources 57. QD-conjugated NVs encapsulated with NPs can also be used as various imaging contrast agents, in combination with computer tomography and other imaging tools, as an indirect method to identify GI lesions 19–21Figure 2Using QD-conjugated NVs to directly detect GI premalignant lesions.…”

Section: Combined Targeting Of Nvs and Hif Against Gi Premalignant Lementioning

confidence: 99%

<p>Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy</p>

Huang¹,

Deng²,

Liang³

2019

IJN

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Premalignant lesions arise from cells that abnormally proliferate and have a tendency to become cancerous. Developing methods to specifically target and remove these premalignant lesions is imperative to the prevention of malignant progression into gastrointestinal (GI) tumors. However, accurate detection and diagnosis of GI precancerous lesions is challenging, as these lesions show little or no structural change. Thus, this prevents early intervention and reduces the success rate of therapy. In this review, we performed a systematic analysis of the technological advancements in the combined application of nanovesicles (NVs) and the human interstitial fluid (HIF) to specifically target GI premalignant lesions. NVs, which include quantum dots (QDs), are small membranous vehicles of a nanometer diameter that are widely used as drug delivery vectors, therapeutic effectors and diagnostic sensors. HIF is the fluid that is present in human interstitial tissues (HITs) in which signaling molecules and agents travel and can be found throughout the body. HIF is exploited by tumor cells for their invasion, migration and spread. Because the HITs span the entire submucosa of the gastrointestinal tract, they have been increasingly targeted in GI tumor therapy. The challenges involved in the combined application of NVs and HIF in the detection, diagnosis, prognosis and therapy of GI premalignant lesions are also discussed.

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Application of novel targeting nanoparticles contrast agent combined with contrast‑enhanced computed tomography during screening for early‑phase gastric carcinoma

Cited by 8 publications

References 46 publications

Expression of the Body-Weight Signaling Players: GDF15, GFRAL and RET and their clinical relevance in Gastric Cancer

Expression of the Body-Weight Signaling Players: GDF15, GFRAL and RET and their clinical relevance in Gastric Cancer

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

<p>Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy</p>

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