Dietary Intake of Folate and Assessment of the Folate Deficiency Prevalence in Slovenia Using Serum Biomarkers

Pravst, Igor; Lavriša, Živa; Hribar, Maša; Hristov, Hristo; Kvarantan, Naska; Seljak, Barbara Koroušić; Gregorič, Matej; Blaznik, Urška; Gregorič, Nadan; Zaletel, Katja; Oblak, Adrijana; Osredkar, Joško; Žmitek, Katja; Kušar, Anita

doi:10.3390/nu13113860

Cited by 19 publications

(18 citation statements)

References 92 publications

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“…Our previous in vivo studies had confirmed that compared with supplementation limited to the periconceptional period, prolonged maternal folic acid supplementation throughout pregnancy was more beneficial to the neurobehavioral development of offspring [8]. Low folate status in early life is linked to the risk of numerous adverse health conditions throughout life, from congenital disabilities to cardiovascular disease, cancer, and cognitive dysfunction in the elderly [1][2][3][4][5][6][7]. However, the impact of folic acid on neurodevelopment is complicated, other than NTDs.…”

Section: Discussionmentioning

confidence: 97%

“…It has been conclusively established that folic acid supplementation prior to and during early pregnancy (up to 12 weeks of gestation) can prevent neural tube defects (NTDs). In recent years, low folate status in early life has been linked to the risk of numerous adverse health conditions throughout life, from congenital disabilities to cardiovascular disease, cancer, and cognitive dysfunction in the elderly [1][2][3][4][5][6][7]. However, the impact of folic acid on neurodevelopment is complicated, other than NTDs.…”

Section: Introductionmentioning

confidence: 99%

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Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis

Zhou

Sun

et al. 2022

IJMS

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Early life stage folate status may influence neurodevelopment in offspring. The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from conception to 2 years) of life. This study aimed to evaluate the effect of early life stage folic acid deficiency on de novo telomere synthesis, neurobehavioral development, and the cognitive function of offspring rats. The rats were divided into three diet treatment groups: folate-deficient, folate-normal, and folate-supplemented. They were fed the corresponding diet from 5 weeks of age to the end of the lactation period. After weaning, the offspring rats were still fed with the corresponding diet for up to 100 days. Neurobehavioral tests, folic acid and homocysteine (Hcy) levels, relative telomere length in brain tissue, and uracil incorporation in telomere in offspring were measured at different time points. The results showed that folic acid deficiency decreased the level of folic acid, increased the level of Hcy of brain tissue in offspring, increased the wrong incorporation of uracil into telomeres, and hindered de novo telomere synthesis. However, folic acid supplementation increased the level of folic acid, reduced the level of Hcy of brain tissue in offspring, reduced the wrong incorporation of uracil into telomeres, and protected de novo telomere synthesis of offspring, which was beneficial to the development of early sensory-motor function, spatial learning, and memory in adolescence and adulthood. In conclusion, early life stage folic acid deficiency had long-term inhibiting effects on neurodevelopment and cognitive function in offspring.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis

Zhou

Sun

et al. 2022

IJMS

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“…In addition, the biomarkers of vitamins were not considered. However, previous studies suggested that diet intake was highly correlated with B vitamin status [ 30 , 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort

Zhang

et al. 2022

Nutrients

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The evidence regarding the intake of dietary folate, vitamin B6, and vitamin B12 in relation to mortality in the general population is limited. This study aimed to examine the relationship between dietary intakes of folate, vitamin B6, and vitamin B12 in relation to all-cause and cause-specific mortality in a large U.S. cohort. This study included a total of 55,569 adults from the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES 1999–2014. Vital data were determined by linking with the National Death Index records through 31 December 2015. Cox proportional hazards models were used to investigate the relationships of all-cause and cause-specific mortality with dietary folate, vitamin B6, and vitamin B12 intake. Dietary intakes of folate and vitamin B6 were inversely associated with mortality from all-cause, cardiovascular disease, and cancer for men and with mortality from all-cause and cardiovascular disease for women. In men, the multivariable hazard ratios (95% confidence intervals) for the highest versus lowest quintiles of folate and vitamin B6 were 0.77 (0.71–0.85) and 0.79 (0.71–0.86) for all-cause mortality, 0.59 (0.48–0.72) and 0.69 (0.56–0.85) for CVD mortality, and 0.68 (0.56–0.84) and 0.73 (0.60–0.90) for cancer mortality, respectively. Among women, the multivariable hazard ratios (95% confidence intervals) for the highest versus lowest quintiles of folate and vitamin B6 were 0.86 (0.78–0.95) and 0.88 (0.80–0.97) for all-cause mortality and 0.53 (0.41–0.69) and 0.56 (0.44–0.73) for CVD mortality, respectively. No significant associations between dietary vitamin B12 and all-cause and cause-specific mortality were observed. In conclusion, higher dietary intakes of folate and vitamin B6 were significantly associated with lower all-cause and cardiovascular mortality. Our findings suggest that increasing the intake of folate and vitamin B6 may lower the mortality risk among U.S. adults.

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“…The Slovenian national dietary survey SI.Menu was conducted in 2017/2018 ( 104 ), and the 2017 edition of the branded foods dataset was used to estimate the nutritional composition of reported foods. This approach has already supported several epidemiological studies, which investigated diet-related-risk factors and population intakes of total/free sugars ( 69 ), dietary fiber ( 70 ), TFAs ( 68 ), vitamin D ( 67 ) and folate ( 71 ).…”

Section: The Exploitation Of Use Of Branded Foods Database In Nutrition Researchmentioning

confidence: 97%

“… List only include studies where Slovenian branded food databases were exploited directly. Food monitoring studies datasets were used for several other studies, for example, to support in the sampling of foods in the food supply for assessment of the content of trans fatty acids in foods ( 64 , 65 ), for assessment of salt iodization ( 66 ), for assessment of dietary intakes ( 67 – 71 ), food marketing ( 25 , 72 – 74 ) and offers in vending machines ( 75 , 76 ). Studies exploiting additional Slovenian branded foods composition datasets ( 44 , 66 , 77 – 79 ) are also not included .…”

Section: The Exploitation Of Use Of Branded Foods Database In Nutrition Researchmentioning

confidence: 99%

Branded Foods Databases as a Tool to Support Nutrition Research and Monitoring of the Food Supply: Insights From the Slovenian Composition and Labeling Information System

et al. 2022

Self Cite

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Branded foods databases are becoming very valuable not only in nutrition research but also for clinical practice, policymakers, businesses, and general population. In contrast to generic foods, branded foods are marked by rapid changes in the food supply because of reformulations, the introduction of new foods, and the removal of existing ones from the market. Also, different branded foods are available in different countries. This not only complicates the compilation of branded foods datasets but also causes such datasets to become out of date quickly. In this review, we present different approaches to the compilation of branded foods datasets, describe the history and progress of building and updating such datasets in Slovenia, and present data to support nutrition research and monitoring of the food supply. Manufacturers are key sources of information for the compilation of branded foods databases, most commonly through food labels. In Slovenia, the branded food dataset is compiled using standard food monitoring studies conducted at all major retailers. Cross-sectional studies are conducted every few years, in which the food labels of all available branded foods are photographed. Studies are conducted using the Composition and Labeling Information System (CLAS) infrastructure, composed of a smartphone application for data collection and online data extraction and management tool. We reviewed various uses of branded foods datasets. Datasets can be used to assess the nutritional composition of food in the food supply (i.e., salt, sugar content), the use of specific ingredients, for example, food additives, for nutrient profiling, and assessment of marketing techniques on food labels. Such datasets are also valuable for other studies, for example, assessing nutrient intakes in dietary surveys. Additional approaches are also being tested to keep datasets updated between food monitoring studies. A promising approach is the exploitation of crowdsourcing through the mobile application VešKajJeš, which was launched in Slovenia to support consumers in making healthier dietary choices.

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Dietary Intake of Folate and Assessment of the Folate Deficiency Prevalence in Slovenia Using Serum Biomarkers

Cited by 19 publications

References 92 publications

Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis

Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis

Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort

Branded Foods Databases as a Tool to Support Nutrition Research and Monitoring of the Food Supply: Insights From the Slovenian Composition and Labeling Information System

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