Dietary Cycloinulooligosaccharides Enhance Intestinal Immunoglobulin A Production in Mice

Ishikawa, Takeshi; Nanjo, Fumio

doi:10.1271/bbb.80733

Cited by 31 publications

(20 citation statements)

References 17 publications

(23 reference statements)

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“…The serum IgG IgM and IgA contents were determined by the radial immunodiffusion technique according to Ishikawa and Nanjo (2009). Briefly, the serum samples were appropriately diluted with 50 mM Tris-HCl buffer (pH 8.0) containing 0.14 M NaCl, 1% BSA, and 0.05% Tween 20.…”

Section: Methodsmentioning

confidence: 99%

Effects of Replacing Soybean Meal with Fermented Rapeseed Meal on Performance, Serum Biochemical Variables and Intestinal Morphology of Broilers

Zeng²,

Ding

2012

Asian Australas. J. Anim. Sci

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This trial was performed to study the effects of replacing soybean meal (SBM) with fermented rapeseed meal (RSM) on growth performance, serum biochemistry variable and intestinal morphology of broilers. A total of 640 d-old Arbor Acres broiler chicks were randomly allocated to 4 dietary treatments, 4 pens per treatment and 40 birds per pen for a 6-wk feeding trial. In the four treatment groups, fermented RSM replaced soybean meal at 0, 5, 10, and 15%, respectively. On 21 d and 42 d, two birds from each pen were randomly selected and slaughtered. Blood samples and sections of duodenum, jejunum, and ileum were collected for measurement of serum biochemical variables and intestinal morphology, respectively. Results showed that body weight gain (BWG) and feed conversion (FC) were significantly (p<0.01) poorer for birds fed the 15% fermented RSM diet than those fed with 0, 5 and 10% fermented RSM diets during all periods. Compared with 0 and 5% fermented RSM groups, IgG content in the serum of birds in 10 and 15% fermented RSM groups was improved (p<0.01) urea nitrogen content of serum was reduced (p<0.01) during both growing and finishing periods. However, IgM, phosphorus and calcium levels increased (p<0.05) only during the growing period. Increased (p<0.05) villus height was observed in the duodenum and jejunum of broilers fed the diet with 10% fermented RSM. In addition, villus height to crypt depth ratio in the jejunum was significantly higher (p<0.01) for birds fed the diet with 10% fermented RSM than for those fed diets with 0, 5 and 15% fermented RSM. The present results suggest that RSM fermented with Lactobacillus fermentum and Bacillus subtilis is a promising alternative protein source and that it could be safely used replace up to 10% SBM in broiler diets.

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Section: Methodsmentioning

confidence: 99%

Effects of Replacing Soybean Meal with Fermented Rapeseed Meal on Performance, Serum Biochemical Variables and Intestinal Morphology of Broilers

Zeng²,

Ding

2012

Asian Australas. J. Anim. Sci

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“…Furthermore, immunoglobulin A (IgA) plays a key role in maintaining a noninflammatory relationship between the host and the gut microbiota (Peterson et al, 2007), as well as microbiota composition (Round and Mazmanian, 2009). Indirect evidence suggests that SCFAs might also promote the secretion of IgA by B cells (Ishikawa and Nanjo, 2009). Another point at which SCFAs operate in the gut is in tissue repair.…”

Section: Scfas Major Mediators Of Gut Homeostasismentioning

confidence: 99%

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

2014

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One explanation for the increased incidence of allergies, asthma, and even some autoimmune diseases has been the hygiene hypothesis. However, recent studies also highlight an important role for diet and bacterial metabolites in controlling various immune pathways, including gut and immune homeostasis, regulatory T cell biology, and inflammation. Dietary-related metabolites engage "metabolite-sensing" G-protein-coupled receptors, such as GPR43, GPR41, GPR109A, GPR120, and GPR35. These receptors are expressed on immune cells and some gut epithelial cells and generally mediate a direct anti-inflammatory effect. Insufficient intake of "healthy foodstuffs" adversely affects the production of bacterial metabolites. These metabolites and those derived directly from food drive beneficial downstream effects on immune pathways. We propose that insufficient exposure to dietary and bacterial metabolites might underlie the development of inflammatory disorders in Western countries. This review highlights what is currently known about diet, metabolites, and their associated immune pathways in relation to the development of inflammatory disease.

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“…This effect of SCFA is primarily dependent on HDAC inhibitor activity but independent of GPR43 [37]. It has also been shown that cycloinulooligosaccharides dietary increased SCFA and IgA production in mice, indirectly indicating that SCFA might promote the secretion of IgA by B cells [38]. …”

Section: Scfa Regulation Of Immune Responsementioning

confidence: 99%

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

et al. 2016

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Gut microbiota has been well recognized in regulation of intestinal homeostasis and pathogenesis of inflammatory bowel diseases. However, the mechanisms involved are still not completely understood. Further, the components of the microbiota which are critically responsible for such effects are also largely unknown. Accumulating evidence suggests that, in addition to pathogen-associated molecular patterns (PAMP), nutrition and bacterial metabolites might greatly impact the immune response in the gut and beyond. Short-chain fatty acids (SCFA), which are metabolized by gut bacteria from otherwise indigestible fiber-rich diets, have been shown to ameliorate diseases in animal models of inflammatory bowel diseases (IBD) and allergic asthma. Although the exact mechanisms for the action of SCFA are still not completely clear, most notable among the SCFA targets is the mammalian G protein-coupled receptor pair of GPR41 and GPR43. In addition to the well-documented inhibition of histone deacetylases (HDAC) activity mainly by butyrate and propionate, which causes anti-inflammatory activities on IEC, macrophages, and dendritic cells, SCFA has recently been implicated in promoting development of Treg cells and possibly other T cells. In addition to animal models, the beneficial effects have also been reported from the clinical studies that used SCFA therapeutically in controlled trial settings in inflammatory disease, in that application of SCFA improved indices of IBD and therapeutic efficacy was demonstrated in acute radiation proctitis. In this review article, we will summarize recent progresses of SCFA in regulation of intestinal homeostasis as well as in pathogenesis of IBD.

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Dietary Cycloinulooligosaccharides Enhance Intestinal Immunoglobulin A Production in Mice

Cited by 31 publications

References 17 publications

Effects of Replacing Soybean Meal with Fermented Rapeseed Meal on Performance, Serum Biochemical Variables and Intestinal Morphology of Broilers

Effects of Replacing Soybean Meal with Fermented Rapeseed Meal on Performance, Serum Biochemical Variables and Intestinal Morphology of Broilers

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

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