Dietary copper and human health: Current evidence and unresolved issues

Bost, Muriel; Houdart, Sabine; Oberli, Marion; Kalonji, Esther; Huneau, Jean‐François; Margaritis, Irène

doi:10.1016/j.jtemb.2016.02.006

Cited by 508 publications

(326 citation statements)

References 79 publications

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“…Fe is required for adequate erythropoietic function (oxygen transport and storage), oxidative metabolism, and cellular immune response (7). Zn is required for general metabolism, and catalytic, structural and regulatory functions (8), and Cu is required for Fe metabolism, antioxidant defense, neuropeptide synthesis, and immune function (9). In the present study, serum concentrations of 55 Mn, 56 Fe, 63 Cu, 66 Zn, 59 Co and 208 Pb were determined in esophageal and lung cancer patients (Table I).…”

Section: Discussionmentioning

confidence: 59%

Changes in blood concentrations of trace metals in cancer patients receiving cisplatin-based chemotherapy

Nakamura¹,

Takahashi²,

Niigata³

et al. 2016

Biomedical Reports

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Abstract. The administration of cisplatin (CDDP) may influence trace metal concentrations in body fluids. In order to test this hypothesis, the blood concentrations of trace metals were determined during the present study in eight Japanese esophageal and lung cancer patients receiving CDDP-based chemotherapy. The levels of manganese, iron (Fe), cobalt, copper, zinc (Zn), platinum and lead in the plasma were determined by inductively coupled plasma-mass spectrometry. In addition, the serum levels of Fe, transferrin and ferritin were evaluated. The baseline plasma concentration of Fe in patients with esophageal cancer was significantly lower than that in lung cancer patients (P=0.011), although there were no significant differences identified with respect to the plasma levels of other trace metals. The data obtained from six fasting patients without blood transfusion demonstrated that plasma concentrations of Fe increased 3.5-fold soon after CDDP treatment and returned to baseline levels ~10 days after therapy. The excessive Fe levels in the bloodstream induced changes in serum ferritin and transferrin levels. Furthermore, serum Zn levels increased 1.8-fold in the 1-3 days following CDDP treatment, and serum cystatin C levels transiently increased. These findings indicate that serum Fe and Zn levels may be useful to understanding the physiological responses in the early stages of CDDP-based chemotherapy, which may be associated with systemic inflammation and/or tissue distribution of CDDP.

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Section: Discussionmentioning

confidence: 59%

Changes in blood concentrations of trace metals in cancer patients receiving cisplatin-based chemotherapy

Nakamura¹,

Takahashi²,

Niigata³

et al. 2016

Biomedical Reports

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“…In human nutrition, essential elements such as Ca, magnesium (Mg), sodium (Na), potassium (K), iron (Fe), zinc (Zn), copper (Cu) and manganese (Mn) are required for the normal maintenance of the human body for several biochemical reactions [10,41]. The Ca, Mg and phosphorus (P) play crucial role in the formation of bones and teeth, while Na and K play role in electrolyte balance and transmission of nerve signals; Cu, Zn and Mn play the role in many enzyme reactions, and Fe constitutes the main parts of the hemoglobin for carrying oxygen from one place to another [9,41].…”

Section: Fishery Products High Mountains Mid-hills Taraimentioning

confidence: 99%

Role of inland fishery and aquaculture for food and nutrition security in Nepal

Gurung

2016

Agric & Food Secur

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Fish as a food is generally acceptable to all regardless of region, religion, race, gender and age across Nepal. The aquaculture and open-water capture fishery contributes about 2 % of agricultural gross domestic production; this share of fisheries sector is tiny but promising having a fastest 8-9 % annual growth rate. Nevertheless, the contribution of fisheries sector is big from nutritional security perspective to poor and marginalized communities and thus cannot be ignored. Generally, the role and importance of the inland water fisheries had been rarely elaborated with perspectives to food and nutritional security in Himalayan landlocked country. Therefore, the aim of this paper was to elucidate the role and potential of inland fisheries for food and nutrition security in Nepal. Information was collected from secondary sources to estimate per capita fish consumption. The per capita consumption was calculated dividing the total fish production by population of specific year, which showed that per capita fish consumption has increased from 125 g in 1975 to 2060 g in year 2013, at least nine times below compared with average global consumption. The value of per capita fish consumption would increase, if native shellfish (gastropod, crab, shrimp, and turtle), frogs and aquatic plants such as foxnut (Euryale ferox) and water chest nut (Trapa sp) which are consumed by ethnic communities are added. In the fish production among the five development regions of the country, Central Development Region was at the top, while Far-Western Development Region was at the bottom. However, on altitudinal basis southern plains contribute highest production, while least is in mountain areas although potentiality of cold-water aquaculture seems high. These imply that support services and innovation should be extended in the Western Development Region and mountainous regions in addition to the plains for improving fisheries-based food and nutrition security.

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“…On the other hand, copper (Cu 2+ ) ions play an important role in the physiological activities of the human body . Cu 2+ ion is the essential trace metal ion which serves as a cofactor for a wide variety of enzymatic activities such as various redox processes, pigmentation of skin and hair to sustain normal human health . Though Cu 2+ ion is the third most abundant essential trace element after iron and zinc in the human body, they are harmful to humans and organisms at high concentration .…”

Section: Introductionmentioning

confidence: 99%

Real‐Time Probe for the Efficient Sensing of Inorganic Fluoride and Copper Ions in Aqueous Media

et al. 2018

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A highly sensitive and efficient rhodamine 6G based probe (P3) was synthesized for the real‐time sensing of F− and Cu2+ ions. The probe P3 was able to show significant color change from brown to pink in the presence of F− and yellow to orange in presence of Cu2+ ions. The UV‐vis studies confirm that the probe P3 was able to detect F− and Cu2+ ions over other ions. Further, UV‐vis titration studies were carried out to understand the detection mechanism and stoichiometry between P3: F− and P3: Cu2+ ions. 1H‐NMR titration was performed to confirm the F− ion binding to probe P3, where, deprotonation of hydrazone proton (‐C=N‐NH‐) was observed. In addition, the limit of detection for P3:F− and P3:Cu2+ ions were found to be 4.02 μM and 1.64 μM respectively which is useful for practical applications. Lastly, probe P3 was used to detect and quantify the F− ions present in a commercially available mouthwash product. Furthermore, P3 was adsorbed on the surface of silica microsphere to detect Cu2+ ions. Interestingly, the material could visually detect 1 ppm of Cu2+ ions which is lower than the permissible limit.

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Dietary copper and human health: Current evidence and unresolved issues

Cited by 508 publications

References 79 publications

Changes in blood concentrations of trace metals in cancer patients receiving cisplatin-based chemotherapy

Changes in blood concentrations of trace metals in cancer patients receiving cisplatin-based chemotherapy

Role of inland fishery and aquaculture for food and nutrition security in Nepal

Real‐Time Probe for the Efficient Sensing of Inorganic Fluoride and Copper Ions in Aqueous Media

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