Dietary conjugated linoleic acid preserves pancreatic function and reduces inflammatory markers in obese, insulin-resistant rats

Dietary conjugated linoleic acid decreases adipocyte size and favorably modifies adipokine status and insulin sensitivity in obese, insulin-resistant rats

“…However, the faCLA rats had greater relative epididymal, perirenal, and visceral adipose tissue weights than faCTL rats [31].…”

“…The protocol for the animal care procedures was approved by the University of Manitoba Protocol Management and Review Committee. Other indices for these rats related to hepatic steatosis, pancreatic function, glucose disposal, and inflammatory markers have been reported elsewhere [30,31]. The dietary formulation and the fatty acid distributions of the CLA and CTL diets have been previously reported [30].…”

Free fatty acid metabolic profile and biomarkers of isolated post-challenge diabetes and type 2 diabetes mellitus based on GC–MS and multivariate statistical analysis

“…For example, palmitic acid (C16:0), a biomarker that can distinguish IPD versus T2DM individuals, may inhibit the metabolic actions of insulin and attenuate insulin signal transduction [27]; whereas linoleic acid (C18:2,n-6), an important biomarker for distinguishing healthy control versus IPD and T2DM individuals, may preserve pancreatic ␤-cell function and improved peripheral glucose utilization [28]. These biomarkers (identified FFAs) may reflect the different features of a glucose metabolic disorder.…”

Trans-10,cis-12-conjugated linoleic acid worsens renal pathology and alters cyclooxygenase derived oxylipins in obesity-associated nephropathy

“…We also have shown that t10,c12 CLA decreases adipocyte dysfunction by reducing cell size and increasing cell number in epididymal adipose tissue of fa/fa Zucker rats [16,28], and it is generally believed that t10,c12 CLA is responsible for effects on body composition [29][30][31][32]. Animal models of inflammation and obesity have shown that a mixture of CLA isomers increases antiinflammatory cytokines and decreases proinflammatory cytokines [33][34][35][36]. On the other hand, studies in humans have documented elevated levels of C-reactive protein with t10,c12 CLA and elevated isoprostanes with supplementation with either isomer [37,38].…”

“…However, rats given the t10,c12 CLA isomer had higher amounts of perirenal fat mass compared to all the other groups. We have previously observed higher relative epididymal and perirenal fat mass in younger fa/fa Zucker rats fed a CLA mixture despite no change in body weight and improvements in glycemic control, pancreatic and hepatic functions [36,66]. Greater levels of adipose mass surrounding the kidney may be related to the increased renal damage in the rats given the 10,c12 CLA diets.…”