Dietary conjugated linoleic acid decreases adipocyte size and favorably modifies adipokine status and insulin sensitivity in obese, insulin-resistant rats

Noto, Amy; Zahradka, Peter; Yurkova, Natalia; Xie, Xueping; Truong, Han; Nitschmann, Evan; Ogborn, Malcolm R.; Taylor, Carla G.

doi:10.1016/j.metabol.2007.06.025

Cited by 44 publications

(37 citation statements)

References 57 publications

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“…The dose of CLA was chosen to parallel research in Zucker Diabetic Fatty rats demonstrating improved glucose tolerance and attenuated hyperinsulinemia (26). Details of the CLA composition, diet formulations, diet fatty acid composition, and other indices for these rats related to hepatic steatosis, pancreatic function, glucose disposal, inflammatory markers, adiposity, and adipokine status have been reported elsewhere (27)(28)(29).…”

Section: Methodsmentioning

confidence: 99%

Dietary trans-10, cis-12 Conjugated Linoleic Acid Reduces Early Glomerular Enlargement and Elevated Renal Cyclooxygenase-2 Levels in Young Obese fa/fa Zucker Rats

Drury¹,

Warford-Woolgar²,

Herchak³

et al. 2009

The Journal of Nutrition

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Conjugated linoleic acid (CLA) slows the progression of disease in models of chronic kidney disease. Because obesity is associated with nephropathy and increased renal cyclooxygenase (COX) levels, the effects of dietary CLA on kidney function, morphology, and COX protein levels in the kidneys of young obese (fa/fa) Zucker rats, a model of metabolic syndrome, were examined. In study 1, 6-wk-old fa/fa and lean Zucker rats were given a mixture of CLA isomers (1.5% CLA, wt:wt) or the control diet (CTL) with no CLA for 8 wk. To examine specific isomer effects, study 2 used the same model with the following diets: 0.4% (g/g) cis-9, trans-11 (c9,t11) CLA; 0.4% trans-10, cis-12 (t10,c12) CLA; a combination of these 2 isomers (0.4% each); or CTL diets with no CLA. In study 1, fa/fa rats given the CLA mixture had 11% smaller kidney weights and 28% smaller glomeruli, and feed intake and body weight did not differ from the CTL rats. In study 2, diet also did not affect body weights, but fa/fa rats given a diet containing t10,c12 CLA had 7% lower kidney weights, 20% smaller glomeruli, and 39% lower COX-2 protein levels than CTL rats. In conclusion, dietary t10,c12 CLA reduces the enlargement of glomeruli in young obesity-associated nephropathy and is associated with lower protein levels of renal COX-2. Long-term studies with CLA supplementation are required to determine whether these changes would lead to reduction in development of renal disease associated with obesity.

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Section: Methodsmentioning

confidence: 99%

Dietary trans-10, cis-12 Conjugated Linoleic Acid Reduces Early Glomerular Enlargement and Elevated Renal Cyclooxygenase-2 Levels in Young Obese fa/fa Zucker Rats

Drury¹,

Warford-Woolgar²,

Herchak³

et al. 2009

The Journal of Nutrition

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“…Lipids were extracted by solvent extraction as described [59], and phospholipids and triacylglycerol fractions were separated by thin layer chromatography (heptane/ isopropyl/acetic acid, 60:40:3 vol/vol/vol) as described [63]. Fatty acids from these fractions were then transmethylated using separate acid and base methylation procedures and quantified by gas chromatography, as described [64]. The results from the two methylation procedures (methanolic hydrochloride acid and sodium methoxide) were combined according to the relative amounts of internal standard based on its addition in equal amounts to duplicate samples.…”

Section: Fatty Acid Analysismentioning

confidence: 99%

Trans-10,cis-12-conjugated linoleic acid worsens renal pathology and alters cyclooxygenase derived oxylipins in obesity-associated nephropathy

Zhan

Shi

Caligiuri

et al. 2015

The Journal of Nutritional Biochemistry

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“…Cells were cultured in a humidifi ed atmosphere at 37°C and 5% CO 2 in DMEM containing conjugated linolenic acid, docosahexanoic acid, epigallocatechin gallate (EGCG), quercetin, resveratrol, and ajoene affect adipogenic differentiation at various life cycle stages of adipocytes (4)(5)(6)(7)(8)(9)(10). These effects are exerted either by induction of apoptosis, inhibition of adipogenesis, stimulating lipolysis, or combinations thereof ( 11 ).…”

Section: Differentiation Of 3t3-l1 and C3h10t1/2 Adipocytesmentioning

confidence: 99%

Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansion and improves dyslipidemia in vivo

Varshney

Shankar

Beg

et al. 2014

Journal of Lipid Research

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Dietary conjugated linoleic acid decreases adipocyte size and favorably modifies adipokine status and insulin sensitivity in obese, insulin-resistant rats

Cited by 44 publications

References 57 publications

Dietary trans-10, cis-12 Conjugated Linoleic Acid Reduces Early Glomerular Enlargement and Elevated Renal Cyclooxygenase-2 Levels in Young Obese fa/fa Zucker Rats

Dietary trans-10, cis-12 Conjugated Linoleic Acid Reduces Early Glomerular Enlargement and Elevated Renal Cyclooxygenase-2 Levels in Young Obese fa/fa Zucker Rats

Trans-10,cis-12-conjugated linoleic acid worsens renal pathology and alters cyclooxygenase derived oxylipins in obesity-associated nephropathy

Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansion and improves dyslipidemia in vivo

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