Dietary arginine modulates nonspecific immune responses in Indian Major Carp, Cirrhinus mrigala exposed to hypoxia

Varghese, Tincy; Kumar, V. Rejish; Gopan, Amrutha; Valappil, Rajendran Kooloth; Sajina, K.A.; Puthiyottil, Mishal; Pal, A. K.

doi:10.1016/j.aquaculture.2020.735613

Cited by 19 publications

(10 citation statements)

References 44 publications

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“…The decreased circulating level of arginine recorded in certain fish such as Senegalese sole and turbot under stressful husbandry conditions indicates its increased requirement and a possible role in stress alleviation (Aragao et al 2008;Costas et al 2008Costas et al , 2011aCostas et al ,b, 2013. Varghese et al (2020a) recently illustrated that the immunosuppressive effects of hypoxia in Cirrhinus mrigala could be reversed by dietary arginine (0.7%) supplementation. Further, the authors noticed that dietary arginine reduced susceptibility of hypoxia-challenged Cirrhinus mrigala to bacterial infection.…”

Section: Protein and Amino Acidsmentioning

confidence: 99%

“…Varghese et al . (2020a) recently illustrated that the immunosuppressive effects of hypoxia in Cirrhinus mrigala could be reversed by dietary arginine (0.7%) supplementation. Further, the authors noticed that dietary arginine reduced susceptibility of hypoxia‐challenged Cirrhinus mrigala to bacterial infection.…”

Section: Stress Mitigation Through Dietary Additives/nutraceuticalsmentioning

confidence: 99%

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Stress management in aquaculture: a review of dietary interventions

Ciji

Akhtar

2021

Reviews in Aquaculture

103

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Over the last few decades, the demand-driven growth in aquaculture has been tremendous due to development and adoption of cutting-edge technologies and production systems such as intensification and high input aquaculture. This growth, however, has witnessed an insurgence of various environmental and husbandry-related stressors posing major challenges to the aquaculture sector limiting its further expansion worldwide. These stressful conditions impair the health of cultured animals and predispose them to diseases resulting in economic losses. Hence, optimizing the stress resilience of the cultured species is paramount to ensure sustainable development of aquaculture sector. Addressing the concerns of stress mitigation in aquaculture, a plethora of research investigations have been intensively carried out all over the world targeting the management of cultured environment as well as cultured species. Among various mitigation strategies, dietary interventions appear to be pliable and a sustainable approach to develop immunocompetence and stress resistance in fish as requirement of several nutrients may increase under stressful conditions. The suboptimal and/or excessive levels of several essential and non-essential nutrients modulate the immune response and stress/disease resistance. Hence, the present review is an inclusive and informative compilation of dietary interventions for management of stress in aquaculture. This review highlights the stress-mitigating roles of different nutritive and non-nutritive compounds/additives such as amino acids, essential fatty acids, phospholipids, vitamins, minerals, carotenoids, different synthetic chemicals and biological derivatives from bacteria, yeast, fungi, algae, plants and animals as a promising stress management strategy to enhance the overall performance of the cultured species.

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Section: Protein and Amino Acidsmentioning

confidence: 99%

Section: Stress Mitigation Through Dietary Additives/nutraceuticalsmentioning

confidence: 99%

Stress management in aquaculture: a review of dietary interventions

Ciji

Akhtar

2021

Reviews in Aquaculture

103

View full text Add to dashboard Cite

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“…(2011) Yellow grouper, Epinephelus awoara 2.51 to 2.83/5.83 to 6.58 T-NOS activity in plasma and liver Red blood cell, hematocrit, hemoglobin SOD activity in plasma and liver Zhou et al. (2012) Indian Major Carp, Cirrhinus mrigala 2.78/8.00 Activity in serum Albumin, globulin, and activity of antiprotease and myeloperoxidase Survival rate against Aeromonas hydrophila Varghese et al. (2020) Jian carp, Cyprinus carpio var.…”

Section: Arginine Immunonutrition In Fishmentioning

confidence: 99%

“…A reduction in the mortality rate of Nile tilapia fingerlings after Streptococcus agalactiae challenge and a boost in immune responses were observed in all supplementations of arginine (from 1.55% to 2.39%) in the diet ( Vianna et al., 2020 ). Dietary arginine supplementation (from 2.08% to 3.48%) also modulated nonspecific immune responses in Indian major carp ( Cirrhinus mrigala ) exposed to hypoxia and reduced its mortality after A. hydrophila infection ( Varghese et al., 2020 ). Arginine also elevated the survival rate of fish under ammonia-nitrogen stress.…”

Section: Arginine Immunonutrition In Fishmentioning

confidence: 99%

Arginine metabolism and its functions in growth, nutrient utilization, and immunonutrition of fish

Wang

2021

Animal Nutrition

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Fish have limited ability in endogenous biosynthesis of arginine. Arginine is an indispensable amino acid for fish, and the arginine requirement varies with fish species and fish size. Recent studies on fish have demonstrated that arginine influences nutrient metabolism, stimulates insulin release, is involved in nonspecific immune responses and antioxidant responses, and elevates disease resistance. Specifically, arginine can regulate energy homeostasis via modulating the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway, and also regulate protein synthesis via activating the target of rapamycin (TOR) signaling pathway. The present article reviews pertinent knowledge of arginine in fish, including dietary quantitative requirements, endogenous anabolism and catabolism, regulation of the endocrine and metabolic systems, and immune-regulatory functions under pathogenic challenge. Our findings showed that further data about the distribution of arginine after intake into specific cells, its sub-cellular sensor to initiate downstream signaling pathways, and its effects on fish mucosal immunity, especially the adaptive immune response against pathogenic infection in different species, are urgently needed.

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“…They occur in the principal rivers of India and are a moderately fast‐growing freshwater carp. They are an important factor of the polyculture and sewage fed carp culture system in India, which contributes approximately 8.7% of the global total carp production 20 . Also, C. mrigala is of great commercial importance (owing to the ease of cultivation) and renowned for taste.…”

Section: Introductionmentioning

confidence: 99%

Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions

Ramesh

Sujitha

Anila

et al. 2020

Environmental Toxicology

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Ciprofloxacin drugs are a second‐generation fluoroquinolone highly prescribed medication against various bacterial infections in human and aquaculture practices. These drugs are chemically designed to persist in the body long enough to achieve target objectives. Extensive usage has resulted in ciprofloxacin becoming a ubiquitous contaminant in the environment. Unfortunately, the ecotoxicological profiles for ciprofloxacin are scanty. This study was aimed to assess the ecotoxicity of ciprofloxacin at environmentally relevant concentrations (1 μg/L, and 1.5 μg/L) to a cultivable fish Cirrhinus mrigala. Responses of antioxidant enzymes, histological anomalies, and inorganic ion levels were studied. SOD activity in gill, liver, and kidney tissues was elevated in ciprofloxacin‐exposed groups when compared with the control group. CAT activity was predominantly decreased in ciprofloxacin treated groups relative to the control group. GST activity in the ciprofloxacin treated groups was increased (except kidney tissues [Treatment I (1 μg/L)], and gill tissues fifteenth day) significantly (p < .05). The LPO level was elevated in the ciprofloxacin treatment groups throughout the study period (except Treatment II (1.5 μg/L) tenth day in kidney tissues). A series of histological anomalies were noticed in the gill, liver, and kidney tissues of the ciprofloxacin treated groups. Ciprofloxacin exposure caused a significant decrease of sodium, potassium, and chloride levels in the plasma of C. mrigala. A parallel among an imbalanced oxidative defense system, tissue structural changes, and alterations of plasma inorganic ions could be considered as a reliable biomarker for antibiotic toxicity study. This study could be a primary platform for further toxicity studies to understand the potential molecular impacts and adverse effects of ciprofloxacin on aquatic organisms.

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Dietary arginine modulates nonspecific immune responses in Indian Major Carp, Cirrhinus mrigala exposed to hypoxia

Cited by 19 publications

References 44 publications

Stress management in aquaculture: a review of dietary interventions

Stress management in aquaculture: a review of dietary interventions

Arginine metabolism and its functions in growth, nutrient utilization, and immunonutrition of fish

Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions

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