Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center‐based Prospective Study

Kotemori, Ayaka; Ishihara, Junko; Zha, Ling; Liu, Rong; Sawada, Norie; Iwasaki, Motoki; Sobue, Tomotaka; Tsugane, Shoichiro

doi:10.1111/cas.13496

Cited by 42 publications

(40 citation statements)

References 34 publications

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“…We reported general characteristics of included studies in Table 1. The most common study designs were the cohort (eleven studies) (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) and case-cohort (five studies) (7,(41)(42)(43)(44), followed by two case-control studies (28,29). These studies were published between 2005 and 2019, and the vast majority were carried out in Europe (N=15), followed by the US (N=2) and Japan (N=1).…”

Section: Resultsmentioning

confidence: 99%

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Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose–Response Meta-analysis

Adani

Filippini

Wise

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Acrylamide is a probable human carcinogen. Aside from occupational exposures and smoking, diet is the main source of exposure in humans. We performed a systematic review of the association between estimated dietary intake of acrylamide and risk of female breast, endometrial, and ovarian cancers in non-experimental studies published through February 25, 2020, and conducted a doseresponse meta-analysis. We identified 18 papers covering 10 different study populations: 16 cohort and 2 case-control studies. Acrylamide intake was associated with a slightly increased risk of ovarian cancer, particularly among never-smokers. For endometrial cancer, risk was highest at intermediate levels of exposure, whereas the association was more linear and positive among never-smokers. For breast cancer, we found evidence of a null or inverse relation between exposure and risk, particularly among never-smokers and post-menopausal women. In a subgroup analysis limited to premenopausal women, breast cancer risk increased linearly with acrylamide intake starting at 20 µg/day of intake. High acrylamide intake was associated with increased risks of ovarian and endometrial cancers in a relatively linear manner, especially among never-smokers. Conversely, little association was observed between acrylamide intake and breast cancer risk, with the exception of premenopausal women.

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Section: Resultsmentioning

confidence: 99%

“…Some studies assessed more than one cancer type. Overall, ten studies assessed breast cancer (28,(30)(31)(32)(33)(34)(35)42,44), seven endometrial cancer (7,29,(35)(36)(37)40,43), and seven ovarian cancer (7,28,35,36,38,39,41), with a total of 18,100, 3561, and 3569 cases of breast, endometrial, and ovarian cancer, respectively.…”

Section: Resultsmentioning

confidence: 99%

Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose–Response Meta-analysis

Adani

Filippini

Wise

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Therefore, in order to evaluate the safety of dietary acrylamide, it is important to examine its influence on cancers in various countries with different dietary sources. Only one study in Asia, however, has assessed the influence of dietary acrylamide intake on the incidence of cancers …”

Section: Introductionmentioning

confidence: 99%

“…Only one study in Asia, however, has assessed the influence of dietary acrylamide intake on the incidence of cancers. 15 Therefore, the aim of this study was to investigate the association between dietary acrylamide intake and the incidence of endometrial or ovarian cancers in Japanese women.…”

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confidence: 99%

Dietary acrylamide intake and the risk of endometrial or ovarian cancers in Japanese women

Kotemori¹,

Ishihara

Zha

et al. 2018

Cancer Science

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A meta‐analysis published in 2015 noted a marginally increased risk of endometrial and ovarian cancers in non‐smoking women with dietary acrylamide intake, but only a few studies were included, and they were limited to Western countries. The aim of this study was to investigate the association between dietary acrylamide intake and endometrial or ovarian cancer risk in the Japan Public Health Center‐based Prospective Study (JPHC Study). In this prospective cohort study, 47 185 participants aged 45‐74 years at the follow‐up starting point in the JPHC Study were enrolled. Dietary acrylamide intake was assessed using a validated food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI). In participants with endometrial and ovarian cancer, the average follow‐up periods were 15.5 and 15.6 years, respectively, and 161 and 122 cases of endometrial and ovarian cancer were diagnosed, respectively. Energy‐adjusted dietary acrylamide intake was negatively associated with endometrial cancer, but the association disappeared after adjusting for coffee consumption with an adjusted HR for the highest vs lowest tertile of 0.85 (95%CI: 0.54‐1.33). No association was observed, however, for ovarian cancer (adjusted HR, 0.77; 95%CI: 0.49‐1.23). Furthermore, after stratifying by smoking status, coffee consumption, alcohol consumption, body mass index, and menopause status, no association was observed. Dietary acrylamide intake was not associated with the risk of endometrial or ovarian cancer in Japanese women with a relatively lower dietary intake of acrylamide compared with Western populations.

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“…FFQs are widely used in large-scale epidemiological studies to determine the effects of long-term dietary acrylamide intake [12,13]. As with most epidemiologic applications of FFQs, ranking is the primary objective.…”

Section: Introductionmentioning

confidence: 99%

Variations in the estimated intake of acrylamide from food in the Japanese population

Kito

Ishihara

Yamamoto

et al. 2020

Nutr J

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Background: Due to concerns of carcinogenicity, it is necessary to assess long-term acrylamide exposure in individuals. Whether the available methods of estimating acrylamide intake can indicate long-term exposure remains unknown. We examined variations in the estimated dietary acrylamide intake of the Japanese population. Methods: The study included 240 participants aged 40-74 years who were a part of the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT). Twelve-day dietary records (DRs) were collected over a one-year period, and food frequency questionnaires (FFQs) were collected twice during the year. Dietary acrylamide intake was estimated from an acrylamide content database. Within-individual variations and between-individual variations were calculated using the random effects model. A linear regression analysis was performed to identify foods with large between-individual variations. Results: The ratios of within-individual variance to between-individual variation were 3.2 for men and 4.3 for women. Days of DRs required to estimate the usual individual intake within 20% of the true mean intake with 95% confidence were 60 days for men and 66 days for women. Coffee/cocoa, potato, and green tea contributed to between-individual variations, in that order, and seven foods contributed to 93% of the between-individual variation. Conclusions: Estimating the acrylamide intake using DRs requires an extended data collection period to estimate the intragroup ranking and habitual intake of individuals. Long-term exposure assessments should be based on methods with less potential for measurement errors, such as the use of biomarkers.

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Dietary acrylamide intake and risk of breast cancer: The Japan Public Health Center‐based Prospective Study

Cited by 42 publications

References 34 publications

Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose–Response Meta-analysis

Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose–Response Meta-analysis

Dietary acrylamide intake and the risk of endometrial or ovarian cancers in Japanese women

Variations in the estimated intake of acrylamide from food in the Japanese population

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