Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose–Response Meta-analysis

Adani, Giorgia; Filippini, Tommaso; Wise, Lauren A.; Halldórsson, Thorhallur I.; Bláha, Luděk; Vinceti, Marco

doi:10.1158/1055-9965.epi-19-1628

Cited by 88 publications

(55 citation statements)

References 72 publications

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“…Several studies have focused on investigating the toxicology of AA, and assessing the health risks of dietary exposure to AA in different food products [ 9 , 10 , 11 , 12 ]. The Food and Agriculture Organization/World Health Organization (FAO/WHO) reported that dietary AA exposure can vary between 0.3 and 0.8 μg/kg BW/day [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…In a Netherlands cohort study on diet and cancer, increased risks of postmenopausal endometrial and ovarian cancer were reported with an increase in dietary AA intake [ 11 ]. Another report suggested that prediagnostic exposure to acrylamide, measured by AA-hemoglobin and glycidamide-hemoglobin adducts, could be related to mortality among breast cancer patient, especially those with endocrine-related types of breast cancer [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Exposure to Acrylamide and Associated Health Risks for the Korean Population

Lee

Kim

2020

IJERPH

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The aim of the study was to estimate the dietary exposure to acrylamide (AA) from the consumption of various processed food and to assess the associated health risks in different age groups in Korea. Potato crisps and French fries presented the highest mean levels of AA (546 and 372 μg/kg, respectively) followed by coffee (353 μg/kg) and tea products (245 μg/kg). The mean AA dietary exposure values for toddlers (≤2 years), children (3–6 years), children (7–12 years), adolescents (13–19 years), adults (20–64 years), and seniors (≥65 years) were estimated to be 0.15, 0.13, 0.06, 0.06, 0.08, and 0.06 μg/kg body weight (BW)/day, respectively. Based on the benchmark dose lower confidence limit (BMDL10) of 0.18 and 0.31 mg/kg BW/day, the calculated mean and 95th percentile values for the margin of exposure were below 10,000 for the all age groups suggesting possible health concern for Koreans. Biscuits, crisps, and coffee were the primary foods contributing to dietary AA exposure among these in the Korean populations. In children, considering the health risk of AA dietary exposure, especially from biscuits and crisps, there is a need to further control and modify dietary habits to ensure lower AA exposure.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary Exposure to Acrylamide and Associated Health Risks for the Korean Population

Lee

Kim

2020

IJERPH

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“…Furthermore, reviews and meta-analyses performed in humans did not report any association between dietary AA intake and the risk of cancer for most organs susceptible to AA-induced carcinogenesis in rodents. This was shown to be the case for lung [ 49 ], breast cancer [ 50 , 51 , 52 , 53 , 54 ], and most studies of ovary cancer [ 52 , 55 , 56 ]. Only one recent study [ 54 ] reported a slight increased risk of ovarian cancer upon AA exposure.…”

Section: Impact Of Aa On Cancer Risk In Humansmentioning

confidence: 99%

“…In humans, the data on AA and endometrial cancer risk are somewhat inconsistent. While some studies and meta-analyses reported no association between dietary AA intake and endometrial cancer [ 52 , 57 , 58 ], others reported increased risk [ 51 , 54 , 56 ]. No associations were reported between AA intake and the risk of skin cancer, particularly in females, which represented the most sensitive gender for this type of cancer in rodents [ 59 ].…”

Section: Impact Of Aa On Cancer Risk In Humansmentioning

confidence: 99%

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

Nehlig

Cunha

2020

Nutrients

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The health implications of acrylamide in food are a matter of concern based on toxicological studies in rodents, which showed that doses of acrylamide more than 100 times higher than those estimated to result from dietary exposure in humans are carcinogenic; however, the cancer types reported in rodents are species-specific, and whether these results can be extrapolated to humans is still in question. In fact, human epidemiological studies revealed a general lack of association between dietary acrylamide exposure and the incidence of different cancer types. Even occupational exposure to acrylamide, resulting in acrylamide exposure nearly 10 times higher than dietary exposure, did not increase tumor occurrence. Furthermore, the consumption of coffee, which is a main contributor of dietary acrylamide exposure, actually decreases the overall incidence of cancer in humans and afford global health benefits, increasing both lifespan and healthspan on ageing. This paradox clearly illustrates the risk of evaluating an individual molecule independently of its complete food matrix, which may have other components that completely override the effects of the considered molecule.

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“…HBM4EU, which is the most recent of the described projects, has, so far, resulted in one publication that addressed breast cancer in a sample of 585 females (age 28–85 years), who were enrolled between 2007 and 2011 [ 94 ]. A further review and the projects overall ambition promise that further work will follow [ 1 ]. Ongoing and planned work strives to link human exposure to general health status by expanding chemical analyses to biospecimen available from established health cohort studies [ 96 ] and address pesticide mixture exposure and associated health effects [ 101 ].…”

Section: Main Textmentioning

confidence: 99%

Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive

et al. 2021

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Environmental factors contribute to the risk for adverse health outcomes against a background of genetic predisposition. Among these factors, chemical exposures may substantially contribute to disease risk and adverse outcomes. In fact, epidemiological cohort studies have established associations between exposure against individual chemicals and adverse health effects. Yet, in daily life individuals are exposed to complex mixtures in varying compositions. To capture the totality of environmental exposures the concept of the exposome has been developed. Here, we undertake an overview of major exposome projects, which pioneered the field of exposomics and explored the links between chemical exposure and health outcomes using cohort studies. We seek to reflect their achievements with regard to (i) capturing a comprehensive picture of the environmental chemical exposome, (ii) aggregating internal exposures using chemical and bioanalytical means of detection, and (iii) identifying associations that provide novel options for risk assessment and intervention. Various complementary approaches can be distinguished in addressing relevant exposure routes and it emerges that individual exposure histories may not easily be grouped. The number of chemicals for which human exposure can be detected is substantial and highlights the reality of mixture exposures. Yet, to a large extent it depends on targeted chemical analysis with the specific challenges to capture all relevant exposure routes and assess the chemical concentrations occurring in humans. The currently used approaches imply prior knowledge or hypotheses about relevant exposures. Typically, the number of chemicals considered in exposome projects is counted in dozens—in contrast to the several thousands of chemicals for which occurrence have been reported in human serum and urine. Furthermore, health outcomes are often still compared to single chemicals only. Moreover, explicit consideration of mixture effects and the interrelations between different outcomes to support causal relationships and identify risk drivers in complex mixtures remain underdeveloped and call for specifically designed exposome-cohort studies.

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Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose–Response Meta-analysis

Cited by 88 publications

References 72 publications

Dietary Exposure to Acrylamide and Associated Health Risks for the Korean Population

Dietary Exposure to Acrylamide and Associated Health Risks for the Korean Population

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive

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