Dietary acrylamide intake and the risk of endometrial or ovarian cancers in Japanese women

Abstract

A meta‐analysis published in 2015 noted a marginally increased risk of endometrial and ovarian cancers in non‐smoking women with dietary acrylamide intake, but only a few studies were included, and they were limited to Western countries. The aim of this study was to investigate the association between dietary acrylamide intake and endometrial or ovarian cancer risk in the Japan Public Health Center‐based Prospective Study (JPHC Study). In this prospective cohort study, 47 185 participants aged 45‐74 years at the follow‐up starting point in the JPHC Study were enrolled. Dietary acrylamide intake was assessed using a validated food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI). In participants with endometrial and ovarian cancer, the average follow‐up periods were 15.5 and 15.6 years, respectively, and 161 and 122 cases of endometrial and ovarian cancer were diagnosed, respectively. Energy‐adjusted dietary acrylamide intake was negatively associated with endometrial cancer, but the association disappeared after adjusting for coffee consumption with an adjusted HR for the highest vs lowest tertile of 0.85 (95%CI: 0.54‐1.33). No association was observed, however, for ovarian cancer (adjusted HR, 0.77; 95%CI: 0.49‐1.23). Furthermore, after stratifying by smoking status, coffee consumption, alcohol consumption, body mass index, and menopause status, no association was observed. Dietary acrylamide intake was not associated with the risk of endometrial or ovarian cancer in Japanese women with a relatively lower dietary intake of acrylamide compared with Western populations.

Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies

“…Recently, some debates are ignited about the acrylamide formed early in the roasting process of coffee beans, a carcinogen in both animals and human [30]. However, we did not have enough evidence to attribute the positive associations between coffee and these two types of cancers to the acrylamide because such a low exposure of acrylamide in coffee is unlikely to cause any cancers in human body [31,32].…”

Dietary Acrylamide Intake and Risk of Esophageal, Gastric, and Colorectal Cancer: The Japan Public Health Center–Based Prospective Study

“…To our knowledge, no study has assessed the effect of dietary acrylamide intake on the risk of esophageal, gastric, or colorectal cancer in Asian populations. In addition, the main sources of dietary acrylamide are coffee and green tea, followed by confectioneries, vegetables, and potatoes in Japan, whereas in Western countries, they are potatobased foods, wheat-based products, and coffee (19). Therefore, it is necessary to examine the influence of acrylamide intake on cancers in various countries with different dietary sources of the chemical.…”

The Evaluation of Childhood Foods and Infant Formula Exposure to Furan, Chloropropanols and Acrylamide Contamination by Food Processing

“…On the other hand, there is not a clear consensus on the relationship between AA and cancer yet. Whereas, some studies reveal that AA increases the risk of contracting ovarian cancer [62], lung cancer [63] and the cancers related to digestive and respiratory systems [64], some other studies determine that AA has no positive relationship with several types of cancer [65][66][67]. However, IARC classifies AA as a probable human carcinogen (group 2A) [68].…”