Dielectrophoretic deformation of breast cancer cells for lab on a chip applications

Chan, Jun Yuan; Kayani, Aminuddin Bin Ahmad; Ali, Mohd Alaudin Mohd; Kok, Chee Kuang; Buyong, Muhamad Ramdzan; Hoe, Susan; Marzuki, Marini; Khoo, Alan Soo‐Beng; Sriram, Sharath; Ostrikov, Kostya Ken

doi:10.1002/elps.201800442

Cited by 6 publications

(10 citation statements)

References 39 publications

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“…Different electrode geometries have been designed and simulated to ensure a sufficient

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for particle polarization. The common shapes of the electrodes used are interdigitated microelectrodes [49–51], circular electrode [31], tapered electrode [52–54], quadrupole electrodes array [55], planar electrode [56], and curved microelectrode [36]. However, this device frequently has issues related to the complex fabrication of electrode.…”

Section: Devices In Dielectrophoresis Applicationmentioning

confidence: 99%

“…Chan et al. [36] studied the deformation of cells by observing the blebbing and shrinkage of the cells using curved microelectrodes patterned onto a glass slide (Fig. 4F).…”

Section: Application Of Dielectrophoresis In Biomedical Fieldmentioning

confidence: 99%

“…Chan et al. [36] focused on the use of DEP system for cancer detection. Pethig summarized the advancement in the use of the DEP technique for stem cell sorting and prediction of stem cell fate potential [37].…”

Section: Introductionmentioning

confidence: 99%

“…The application of DEP to the biomedical field has recently gained significant attention. DEP can be used in several areas including cancer disease diagnostics [36], stem cell‐based therapy [32,42], and diagnosis of infectious diseases [30,43,44]. In this review, the recent applications of DEP to the biomedical field are discussed.…”

Section: Introductionmentioning

confidence: 99%

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Dielectrophoresis applications in biomedical field and future perspectives in biomedical technology

et al. 2021

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Dielectrophoresis (DEP) is a technique to manipulate trajectories of polarisable particles in nonuniform electric fields by utilizing unique dielectric properties. The manipulation of a cell using DEP has been demonstrated in various modes, thereby indicating potential applications in the biomedical field. In this review, recent DEP applications in the biomedical field are discussed. This review is intended to highlight research work that shows significant approach related to DEP application in biomedical field reported between 2016 and 2020. First, single‐shell model and multiple‐shell model of cells are introduced. Current device structures and recently introduced electrode patterns for DEP applications are discussed. Second, the biomedical uses of DEP in liquid biopsies, stem cell‐based therapies, and diagnosis of infectious diseases due to bacteria and viruses are presented. Finally, the challenges in DEP research are discussed, and the reported solutions are explained. DEP's potential research directions are mentioned.

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“…Different electrode geometries have been designed and simulated to ensure a sufficient

\nabla false| \vec{normalE} false|

Section: Devices In Dielectrophoresis Applicationmentioning

confidence: 99%

“…Chan et al. [36] studied the deformation of cells by observing the blebbing and shrinkage of the cells using curved microelectrodes patterned onto a glass slide (Fig. 4F).…”

Section: Application Of Dielectrophoresis In Biomedical Fieldmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dielectrophoresis applications in biomedical field and future perspectives in biomedical technology

et al. 2021

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“…Their experiments demonstrated a higher percentage of cell shrinkage, and APS ≈ 20% (average shrinkage percentage), when cancer cells are exposed to higher frequency and peak to peak voltage electric field. 175…”

Section: ■ Theoretical Considerationsmentioning

confidence: 99%

Dielectrophoretic Manipulation of Cancer Cells and Their Electrical Characterization

Turcan

Olariu

2020

ACS Comb. Sci.

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Electromanipulation and electrical characterization of cancerous cells is becoming a topic of high interest as the results reported to date demonstrate a good differentiation among various types of cells from an electrical viewpoint. Dielectrophoresis and broadband dielectric spectroscopy are complementary tools for sorting, identification, and characterization of malignant cells and were successfully used on both primary tumor cells and culture cells as well. However, the literature is presenting a plethora of studies with respect to electrical evaluation of these type of cells, and this review is reporting a collection of information regarding the functioning principles of different types of dielectrophoresis setups, theory of cancer cell polarization, and electrical investigation (including here the polarization mechanisms). The interpretation of electrical characteristics against frequency is discussed with respect to interfacial/Maxwell−Wagner polarization and the parasitic influence of electrode polarization. Moreover, the electrical equivalent circuits specific to biological cells polarizations are discussed for a good understanding of the cells' morphology influence. The review also focuses on advantages of specific low-conductivity buffers employed currently for improving the efficiency of dielectrophoresis and provides a set of synthesized data from the literature highlighting clear differentiation between the crossover frequencies of different cancerous cells.

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A correlation of conductivity medium and bioparticle viability on dielectrophoresis‐based biomedical applications

et al. 2023

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Dielectrophoresis (DEP) bioparticle research has progressed from micro to nano levels. It has proven to be a promising and powerful cell manipulation method with an accurate, quick, inexpensive, and label-free technique for therapeutic purposes. DEP, an electrokinetic phenomenon, induces particle movement as a result of polarization effects in a nonuniform electrical field. This review focuses on current research in the biomedical field that demonstrates a practical approach to DEP in terms of cell separation, trapping, discrimination, and enrichment under the influence of the conductive medium in correlation with bioparticle viability. The current review aims to provide readers with an in-depth knowledge of the fundamental theory and principles of the DEP technique, which is influenced by conductive medium and to identify and demonstrate the biomedical application areas. The high conductivity of physiological fluids presents obstacles and opportunities, followed by bioparticle viability in an electric field elaborated in detail. Finally, the drawbacks of DEP-based systems

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Dielectrophoretic deformation of breast cancer cells for lab on a chip applications

Cited by 6 publications

References 39 publications

Dielectrophoresis applications in biomedical field and future perspectives in biomedical technology

Dielectrophoresis applications in biomedical field and future perspectives in biomedical technology

Dielectrophoretic Manipulation of Cancer Cells and Their Electrical Characterization

A correlation of conductivity medium and bioparticle viability on dielectrophoresis‐based biomedical applications

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