Dielectric barrier discharge micro-plasma emission source for the determination of thimerosal in vaccines by photochemical vapor generation

On the coupling of hydride generation with atmospheric pressure glow discharge in contact with the flowing liquid cathode for the determination of arsenic, antimony and selenium with optical emission spectrometry

“…They sheared a considerable interest and are the subject of a growing number of works [1][2][3]. Among developed and studied in recent years miniaturized excitation sources there are dielectric barrier discharge (DBD), electrolyte as cathode glow discharge (ELCAD), liquid sampling atmospheric pressure glow discharge (LS-APGD), solution cathode glow discharge (SCGD), capacitively coupled plasma (CCP) and microstrip plasma (MSP) [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. In general, these new excitation sources enable efficient excitation of elements with relatively low excitation potentials, i.e., alkali and alkaline earth elements and some of transition metals.…”

“…In general, these new excitation sources enable efficient excitation of elements with relatively low excitation potentials, i.e., alkali and alkaline earth elements and some of transition metals. Limits of detection (LODs) of elements usually vary from several to tens micro gram per liter and because of that miniaturized excitation sources are commonly used for their quantification in different samples [4][5][6][7][8][9][10][11][12][13][14][15][16]. On the other hand, mentioned radiation sources are rarely utilized for the determination of elements with high excitation potentials, e.g., As, Sb or Se, with OES.…”

Development and ICH Validation of a RP-HPLC-UV Method for the Quantification of Thimerosal in Topic Creams

“…Most of them are focused on its application in sterile pharmaceutical formulations. Thus, sensitivity methods based on total Hg quantification, involving mercury vapor generation, has been performed in vaccines (PVG-OES) [11] (DBD-PIV-AFS) [12] or in ophthalmic solutions by flow injection (FI) coupled with UV/microwave-assisted photochemical (CVG-AFS) detection [13]. Direct determination of TMS, using high performance liquid chromatography (HPLC) has also been developed in vaccines [14][15][16] or ophthalmic solutions [17][18][19][20][21].…”

Simultaneous determination of thimerosal and aluminum in vaccines and pharmaceuticals with the use of HPLC method

“…Determination of thimerosal in pharmaceuticals is carried out in two ways: as total Hg [26][27][28][29][30][31][32][33][34] or directly as thimerosal [35][36][37][38][39][40][41][42][43][44]. The total Hg determination methods require mineralization and atomization of sample to form mercury vapor.…”