Die Wasserstoffionenkonzentration des Hirngewebes bei raumfordernden intracraniellen Prozessen

Pampus, F

doi:10.1007/bf01402010

Cited by 26 publications

(9 citation statements)

References 11 publications

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“…6 Although the average pH e of two kinds of brain tumours is slightly different, they are both more acidic than normal brain tissues. 38 Similar results have also been observed in other tissues, such as lung, 34 breast, 39 and skeletal muscle. [35][36][37] Thus, it is very clear that most cancer cells usually have a more acidic pH e than their corresponding normal cells, and the differences vary from 0.3-0.7.…”

Section: Extracellular Ph (Ph E )supporting

confidence: 74%

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Manipulating extracellular tumour pH: an effective target for cancer therapy

2018

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Section: Extracellular Ph (Ph E )supporting

confidence: 74%

“…These data were selected based on the measurements using pH-sensitive electrodes. 4,6,[34][35][36][37][38][39] As shown in Fig. 1, pH e of cancer cells is 0.3-0.7 pH unit lower than that of corresponding normal cells.…”

Section: Extracellular Ph (Ph E )mentioning

confidence: 84%

Manipulating extracellular tumour pH: an effective target for cancer therapy

2018

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“…The molecular mechanisms behind the putative anti-oncogenic effects of ASICs expression is, however, unknown. Data from in vivo and in vitro studies clearly indicate that the average pH is ~0.2 pH units lower in GBM (pH 6.97) than in normal brain tissue (pH 7.2) 41 . Anti-angiogenic treatment with e.g.…”

Section: Discussionmentioning

confidence: 97%

Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3

Tian

Bresenitz

Reska

et al. 2017

Sci Rep

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Acidic microenvironment is commonly observed in tumour tissues, including glioblastoma (GBM), the most aggressive and lethal brain tumour in adults. Acid sensing ion channels (ASICs) are neuronal voltage-insensitive sodium channels, which are sensors of extracellular protons. Here we studied and functionally characterized ASICs in two primary glioblastoma stem cell lines as cell culture models. We detected transcripts of the ACCN2 and ACCN3 genes, coding for ASIC1 and ASIC3, respectively, but not transcripts of ACCN1 (coding for ASIC2). Available microarray data confirmed that ACCN1 is downregulated in glioma. Western blotting confirmed expression of ASIC1 and ASIC3, the most proton-sensitive ASICs, in both GBM cell lines. We characterized ASICs functionally using whole-cell patch clamp and detected different types of acid-sensitive currents. Some of these currents had kinetics typical for ASICs and were sensitive to specific toxin inhibitors of ASIC1a or ASIC3, demonstrating that the GBM cell lines express functional ASIC1a and ASIC3 that may enable GBM cells to sensitively detect extracellular pH in a tumour tissue. Microarray data revealed that expression of ACCN2 and ACCN3 is associated with improved survival of patients suffering from gliomas, suggesting that preserved susceptibility to extracellular pH may impair tumour growth.

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“…4). 1966, Pampus 1963) which lead to vasodilatation and finally--in fully developed oedema--to complete paralysis of the cerebral vessels. 5).…”

Section: Resultsmentioning

confidence: 99%

Experimental investigations on the regulation of the spinal cord circulation

Palleske

1969

Acta neurochir

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With 5 FiguresIn our preceding studies on the regulation of the spinal cord circulation under physiological conditions we were able to demonstrate, that, qualitatively, there were no factors different from those governing the regulation of cerebral circulation (Palleske and Herrmann 1968, Palleske 1968). In the meantime these results have been confirmed by Brock (1969). Brock and coll., however, using radio-isotopes, found quantitative differences in the regulation of circulation in various cerebral and spinal regions. For this reason it is of special interest, to discover whether the blood flow in the injured spinal cord is affected in a manner corresponding to that seen in cerebral oedema. MethodThe experiments have been performed in 8 dwarf pigs. A detailed description of the technique was given in part I of our publication. A cold injury of the cord was produced, under otherwise unchanged experimentM conditions, in the region of the lumbar enlargement. A copper-cube (length 10 mm), cooled in a CO2-aeetone mixture, was placed on the intact dura in this area for 30 see and was then thawed off by rinsing with Ringer's solution.Only then were the probes applied to the areas bordering on the lesion and to the healthy spinal cord. We have demonstrated (Palleske, Herrmann and Kremer 1968) that this method produces an oedema which is relatively exactly measurable and reprodueeable, and which is comparable to the oedema most frequently seen in neurosurgicM material. 320 H. Palleske :

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Die Wasserstoffionenkonzentration des Hirngewebes bei raumfordernden intracraniellen Prozessen

Cited by 26 publications

References 11 publications

Manipulating extracellular tumour pH: an effective target for cancer therapy

Manipulating extracellular tumour pH: an effective target for cancer therapy

Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3

Experimental investigations on the regulation of the spinal cord circulation

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