Die Schutzwirkung von Cysteamin und β-Aminoäthylisothiouronium (AET) gegen die chromosomenschädigende Aktivität von Trenimon® in menschlichen Lymphocyten in vitro

Becher, R.; Gebhart, Erich

doi:10.1007/bf00273185

Cited by 16 publications

(2 citation statements)

References 8 publications

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“…On the other hand, the antimutagenicity of cysteamine against chemical mutagens has also been the subject of a number of studies. In 1973, Becher and Gebhart demonstrated cysteamine's strong, dose-dependent, in vitro protection of human lymphocytes from chromosomal damage induced by trenimon, an anticancer drug that acts via alkylation and is well-known for its clastogenic effects [ 75 ]. Rosin and Stich reported that cysteamine had good, dose-dependent antimutagenicity against mutations induced by 50–100 μ M N-acetoxy-2-acetylaminofluorene in Salmonella typhimurium [ 76 ].…”

Section: The Radiation Protection Effect By Cysteaminementioning

confidence: 99%

A Review on the Antimutagenic and Anticancer Effects of Cysteamine

Lee

2023

Advances in Pharmacological and Pharmaceutical Sciences

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Cancer is one of the leading causes of death worldwide. First-line treatments usually include surgery, radiotherapy, and/or systemic therapy. These methods can be associated with serious adverse events and can be toxic to healthy cells. Despite the new advances in cancer therapies, there is still a continuous need for safe and effective therapeutic agents. Cysteamine is an aminothiol endogenously synthetized by human cells during the degradation of coenzyme-A. It has been safely used in humans for the treatment of several pathologies including cystinosis and neurodegenerative diseases. Cysteamine has been shown to be a potent antimutagenic, anticarcinogenic, and antimelanoma in various in vitro and in vivo studies, but a review on these aspects of cysteamine’s use in medicine is lacking in the current literature. The efficacy of cysteamine has been shown in vitro and in vivo for the treatment of different types of cancer, such as gastrointestinal cancer, pancreatic cancer, sarcomas, hepatocellular carcinoma, and melanoma, leading to the significant reduction of lesions and/or the increase of survival time. Although the mechanisms of action are not fully understood, possible explanations are (i) free radical scavenging, (ii) alteration of the tumor cell proliferation by affecting nucleic acid and protein synthesis or inhibition of DNA synthesis, and (iii) hormone regulation. In conclusion, regarding the high safety profile of cysteamine and the current literature data presented in this article, cysteamine might be considered as an interesting molecule for the prevention and the treatment of cancer. Further clinical studies should be performed to support these data in humans.

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Section: The Radiation Protection Effect By Cysteaminementioning

confidence: 99%

A Review on the Antimutagenic and Anticancer Effects of Cysteamine

Lee

2023

Advances in Pharmacological and Pharmaceutical Sciences

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“…On the other hand, the antimutagenicity of cysteamine against chemical mutagens has also been the subject of a number of studies. In 1973, Becher and Gebhart demonstrated cysteamine's strong, dose-dependent,in vitro protection of human lymphocytes from chromosomal damage induced by trenimon, an anti-cancer drug that acts via alkylation and is well-known for its clastogenic effects [67]. Rosin & Stich (1978) reported that cysteamine had good, dose-dependent antimutagenicity against mutations induced by 50-100 μM N-acetoxy-2-acetylaminofluorene in Salmonella typhimurium [68].…”

Section: The Radiation Protection Effect By Cysteaminementioning

confidence: 99%

A review on the anti-mutagenic and anti-cancer effects of Cysteamine

Lee

2022

Preprint

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Cysteamine is an aminothiol endogenously synthetized by human cells during the degradation of coenzyme A. Since the 1950s, this substance has been used in radiation protection, immunomodulation, and is the sole FDA-approved oral agent for the treatment of cystinosis. Many in vitro and in vivo studies recommend cysteamine as an effective anti-carcinogenic agent. In this article, we will review the preventive and therapeutic effects of cysteamine for 3 types of cancers: carcinomas, sarcomas and melanomas. Cysteamine has been shown to be effective in vitro and in vivo for the treatment of different cancer types generally leading to the significant reduction of lesions and/or the increase of survival time. Cysteamine has been shown to enhance the anti-melanoma effect of doxorubicin in vivo and cysteamine derivatives have shown anti-melanoma efficacy in animal models. Although the mechanisms of action are not fully understood, possible explanations on the pathophysiology of cell suppression by cysteamine are given : (i) free radical scavenging (ii) alteration of the tumor cell proliferation by affecting nucleic acid and protein synthesis or inhibition of DNA synthesis (iii) hormone regulation.

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The action of three anticlastogens on the induction of sister chromatid exchange by trenimon and 8‐hydroxyquinoline sulfate in human lymphocyte cultures

Gebhart¹,

Kappauf²

1980

Environ. mutagen

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The influence of the anticlastogens beta-aminoethylisothiouronium (AET), d,l-homocysteinethiolactone (HCT), and 1-cysteine (CYS) on the frequency of sister chromatid exchanges (SCEs) induced by the chromosome damaging chemicals Trenimon and 8-hydroxyquinoline sulfate (8-HQS), was investigated in human lymphocyte cultures. None of the anticlastogens significantly influenced the SCE rate, whereas in the same or previous experiments the chromosome-breaking effect of these clastogens was distinctly reduced by the anticlastogens. These results suggest that the sites of anticlastogenic activity do not coincide with the sites of SCE formation. SCE analysis, although it yields interesting and important information about the action of chemicals on genetic material, cannot replace classical aberration analysis, because the two parameters apparently reflect different patterns of molecular and cytogenetic activity of mutagens.

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Die Schutzwirkung von Cysteamin und β-Aminoäthylisothiouronium (AET) gegen die chromosomenschädigende Aktivität von Trenimon® in menschlichen Lymphocyten in vitro

Cited by 16 publications

References 8 publications

A Review on the Antimutagenic and Anticancer Effects of Cysteamine

A Review on the Antimutagenic and Anticancer Effects of Cysteamine

A review on the anti-mutagenic and anti-cancer effects of Cysteamine

The action of three anticlastogens on the induction of sister chromatid exchange by trenimon and 8‐hydroxyquinoline sulfate in human lymphocyte cultures

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