Die percutane Absorption von tritium-markiertem Panthenol bei Mensch und Tier

Stuettgen, G; Krause, H.

doi:10.1007/bf00477492

Cited by 14 publications

(8 citation statements)

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“…Our results strongly suggest that dexpanthenol was released from the lipophilic vehicles and penetrated the epidermis, or else our findings would be hard to account for. Our results thus confirm Stüttgen's observation of percutaneous absorption of tritiated dexpanthenol [19].…”

Section: Discussionsupporting

confidence: 92%

Effect of Topically Applied Dexpanthenol on Epidermal Barrier Function and Stratum Corneum Hydration

Gehring¹,

Gloor²

2011

Arzneimittelforschung

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In a randomized, double-blind, placebo-controlled study the effect of topical dexpanthenol (CAS 81-13-0) formulated in two different lipophilic vehicles on epidermal barrier function in vivo was carried out. Seven days' treatment with dexpanthenol improved stratum corneum hydration and reduced transepidermal water loss. Active treatment was statistically different from the vehicle control on both measures. Our results suggest that topical dexpanthenol formulated in either lipophilic vehicle stabilizes the skin barrier function.

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Section: Discussionsupporting

confidence: 92%

Effect of Topically Applied Dexpanthenol on Epidermal Barrier Function and Stratum Corneum Hydration

Gehring¹,

Gloor²

2011

Arzneimittelforschung

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“…These experiments demonstrate a positive effect of pantothenate on the proliferation and migration of dermal fibroblasts especially at a concentration of 20 μg/ml. The dosages of pantothenate applied in our in vitro experiments are in good correlation to in vivo studies by Burlet (27) and Stütgen and Krause (24) who measured the penetration of panthenol in human and rodent skin. Burlet described a skin concentration of pantothenic acid of 30–40 μg/g in rat skin after repeated percutaneous application of 20 mg of panthenol, which is equivalent to dosages regularly applied to human skin.…”

Section: Discussionsupporting

confidence: 82%

“…Because CoA is not transported across barrier membranes, pantothenic acid is the compound that is transferred in the body. Panthenol is an alcohol analogue to pantothenic acid, depending on the formulation it is well absorbed in human skin (24) and can be oxidized to pantothenic acid by alcohol dehydrogenase (25). Panthenol has therefore been used for many years for skin protection and improvement in skin regeneration after wounding (2).…”

Section: Discussionmentioning

confidence: 99%

Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts

Wiederholt¹,

Heise²,

Skazik³

et al. 2009

Experimental Dermatology

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Topical application of pantothenate is widely used in clinical practice for wound healing. Previous studies identified a positive effect of pantothenate on migration and proliferation of cultured fibroblasts. However, these studies were mainly descriptive with no molecular data supporting a possible model of its action. In this study, we first established conditions for an in vitro model of pantothenate wound healing and then analysed the molecular effects of pantothenate. To test the functional effect of pantothenate on dermal fibroblasts, cells were cultured and in vitro proliferation tests were performed using a standardized scratch test procedure. For all three donors analysed, a strong stimulatory effect of pantothenate at a concentration of 20 microg/ml on the proliferation of cultivated dermal fibroblasts was observed. To study the molecular mechanisms resulting in the proliferative effect of pantothenate, gene expression was analysed in dermal fibroblasts cultivated with 20 microg/ml of pantothenate compared with untreated cells using the GeneChip Human Exon 1.0 ST Array. A number of significantly regulated genes were identified including genes coding for interleukin (IL)-6, IL-8, Id1, HMOX-1, HspB7, CYP1B1 and MARCH-II. Regulation of these genes was subsequently verified by quantitative real-time polymerase chain reaction analysis. Induction of HMOX-1 expression by pantothenol and pantothenic acid in dermal cells was confirmed on the protein level using immunoblots. Functional studies revealed the enhanced suppression of free radical formation in skin fibroblasts cultured with panthenol. In conclusion, these studies provided new insight in the molecular mechanisms linked to the stimulatory effect of pantothenate and panthenol on the proliferation of dermal fibroblasts.

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“…Dexpanthenol is a stable alcoholic analog of pantothenic acid. Contrary to pantothenic acid, it is well absorbed through the skin (4,5). Bepanthen TM was first introduced as an ointment approximately 70 years ago (in 1944).…”

Section: Introductionmentioning

confidence: 99%

Topical use of dexpanthenol: a 70th anniversary article

Proksch

Bony

Trapp

et al. 2017

Journal of Dermatological Treatment

112

143

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Approximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen TM Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the field of dermatology and skin care. Various studies confirmed dexpanthenol's moisturizing and skin barrier enhancing potential. It prevents skin irritation, stimulates skin regeneration and promotes wound healing. Two main directions in the use of topical dexpanthenol-containing formulations have therefore been pursued: as skin moisturizer/skin barrier restorer and as facilitator of wound healing. This 70th anniversary paper reviews studies with topical dexpanthenol in skin conditions where it is most frequently used. Although discovered decades ago, the exact mechanisms of action of dexpanthenol have not been fully elucidated yet. With the adoption of new technologies, new light has been shed on dexpanthenol's mode of action at the molecular level. It appears that dexpanthenol increases the mobility of stratum corneum molecular components which are important for barrier function and modulates the expression of genes important for wound healing. This review will update readers on recent advances in this field. ARTICLE HISTORY

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Die percutane Absorption von tritium-markiertem Panthenol bei Mensch und Tier

Cited by 14 publications

References 0 publications

Effect of Topically Applied Dexpanthenol on Epidermal Barrier Function and Stratum Corneum Hydration

Effect of Topically Applied Dexpanthenol on Epidermal Barrier Function and Stratum Corneum Hydration

Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts

Topical use of dexpanthenol: a 70th anniversary article

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