Die Guanidin- und Dimethylguanidin-Toxikose des Säugetiers und ihre physio-pathologische Bedeutung

EFFECTS OF SOME ISOTHIOUREA AND GUANIDINE SALTS ON VARIOUS PREPARATIONS OF SMOOTH AND STRIPED MUSCLE

“…It has been known for some considerable time that guanidine can potentiate the action of acetylcholine on striped muscle (Frank, Stern, and Nothmann, 1921 ;Harvey, 1940). The finding that bases like asym-dimethylguanidine, methyl and ethyl isothiourea also possess this property is hardly surprising considering the numerous other analogies that have been noted in their pharmacological behaviour (Fastier and Smirk, 1947).…”

Guanidine Retention and Calcium Reserve as Antagonistic Factors in Carbon Tetrachloride and Chloroform Poisoning

“…Paton and Findlay (27) studied the intoxication produced by guanidine or methyl guanidine and described symptoms very similar to the tetany seen after parathyroidectomy and believed that the two conditions are identical. Perhaps the most complete pharmacological and toxicological study of guanidine compounds which we have is a paper by Frank, Stern, and Nothmann (28). A variety of guanidine compounds were used with adequate numbers of animals of different species, the lethal doses carefully determined, and the symptoms noted.…”