Die Bedeutung von Kollagen und Kollagenasen in der Wundheilung

Frieß, Wolfgang; Metzmacher, Iris; Wild, T.

doi:10.1007/978-3-211-69454-1_12

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…More often than not, especially with chronic wounds, critical colonisation is a permanent situation. In this case, the microbial load might trigger an inflammation process, which contributes to a chronification of the wound and involves specific signs such as persistent fibrinous coating (which must by no means be mistaken for pus) [29].…”

Section: Diagnosis Of Local Wound Infectionmentioning

confidence: 99%

A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polihexanide

Dissemond¹,

Gerber²,

Krämer³

et al. 2010

Journal of Tissue Viability

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Section: Diagnosis Of Local Wound Infectionmentioning

confidence: 99%

A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polihexanide

Dissemond¹,

Gerber²,

Krämer³

et al. 2010

Journal of Tissue Viability

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“…Moreover, bioactive wound pads seemingly modulate and improve the physiological stages of wound healing [32]. Therefore, products containing collagen and hyaluronic acid are used [33,34]. In addition, another interesting approach to improve wound healing is the use of growth factors due to their immense importance in mediating the wound closure processes.…”

Section: Discussionmentioning

confidence: 99%

Development of a Novel Polymer-Based mRNA Coating for Surgical Suture to Enhance Wound Healing

et al. 2019

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A therapeutic strategy to improve wound healing has become an increasingly important medical task due to the rising incidence of adiposity and type II diabetes as well as the proceeding population aging. In order to cope with the resulting burdens, new strategies to achieve rapid and complete wound healing must now be developed. Accordingly, the development of a bioactive wound dressing in the form of a messengerRNA (mRNA)-bearing poly(lactide-co-glycolide acid) (PLGA) coating on surgical suture is being pushed further with this study. Furthermore, the evaluation of the polymer-based transfection reagent Viromer RED has shown that it can be used for the transfection of eukaryotic cells: The mRNA gets properly complexed and translated into a functional protein.In addition, the mRNA-PLGA coating triggered the expression of the keratinocyte growth factor (KGF) in HaCat cells although KGF is not expressed under physiological conditions. Moreover, transfection via surgical sutures coated with mRNA does not affect the cell viability and a proinflammatory reaction in the transfected cells is not induced. These properties make the mRNA-PLGA coating very attractive for the in vivo application. For the future, this could mean that through the use of mRNA-coated sutures in surgical wound closure, cells in the wound area can be transfected directly, thus accelerating and improving wound healing.

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The significance of collagen dressings in wound management: a review

Pallaske¹,

Pallaske²,

Herklotz³

et al. 2018

J Wound Care

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Clinical experience and research has improved our understanding of wound healing which, in turn, has enabled health professionals to aid wound healing and manufacturers to develop modern wound dressings. The significant role of collagen in wound healing has led to the development of numerous products on the basis of this biological material. The main focus of this review is to provide a critical appraisal of publications about collagen and acellular collagen dressings with a fleece-like or spongy structure. It is intended for clinicians and researchers, and aims to keep them up-to-date in the complex field of interactive, collagen-based wound dressings, including their manufacture, combination possibilities, mechanisms of action, performance in the promotion of wound healing and indications. Despite the small number of clinical studies, the importance of acellular collagen dressings with a fleece-or sponge-like structure is likely to increase in the future. As there is no ideal wound dressing, the knowledge attained is meant to support health professionals in selecting the right product, and pave the way for new applications and clinical studies.

show abstract

Die Bedeutung von Kollagen und Kollagenasen in der Wundheilung

Cited by 3 publications

References 9 publications

A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polihexanide

A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polihexanide

Development of a Novel Polymer-Based mRNA Coating for Surgical Suture to Enhance Wound Healing

The significance of collagen dressings in wound management: a review

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