A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polihexanide

Dissemond, Joachim; Gerber, Veronika; Krämer, Axel; Riepe, G.; Strohal, Robert; Vasel-Biergans, A.; Eberlein, Thomas

doi:10.1016/j.jtv.2010.06.002

Cited by 51 publications

(30 citation statements)

References 9 publications

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“…Related products contain only substances that nowadays pass a critical evaluation. This has been confirmed by consensus recommendations [18,19] . Various polihexanide-containing products are available for wound treatment, and these are now also gaining in importance throughout Europe and throughout the world.…”

Section: Polihexanide For Wound Treatmentsupporting

confidence: 75%

Polihexanide for Wound Treatment – How It Began

Roth¹,

Brill

2010

Skin Pharmacol Physiol

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The essential role of wound antiseptics was discovered in the 18th century. Since then, many different procedures and substances have been developed and used for this indication. In the 1980s, polihexanide was introduced by Prof. Willenegger in Switzerland. Today, consensus recommendations confirm the potential of this substance for wound treatment. Various polihexanide-containing wound care products are available and these are now also gaining in importance throughout Europe and throughout the world.

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Section: Polihexanide For Wound Treatmentsupporting

confidence: 75%

Polihexanide for Wound Treatment – How It Began

Roth¹,

Brill

2010

Skin Pharmacol Physiol

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“…No microbial resistance has been observed. [ 27 ] In a not yet published prospective, randomized, controlled, double-blind clinical trial the use of polyhexanide-coated CVCs is associated with a significant reduction in BSI but not with the reduction in colonization rate. [ 28 ] The antimicrobial mode of action is dependent on the type of the incorporated additive.…”

Section: Quantitative Comparison Of the Antimicrobial Effi Ciency Of mentioning

confidence: 99%

“…PHMB has a broad antimicrobial spectrum and excellent cell and tissue tolerability, as well as a low risk of contact sensitization and adjuvant effects to wound healing. No microbial resistance has been observed . In a not yet published prospective, randomized, controlled, double‐blind clinical trial the use of polyhexanide‐coated CVCs is associated with a significant reduction in BSI but not with the reduction in colonization rate …”

Section: Introductionmentioning

confidence: 96%

Quantitative Comparison of the Antimicrobial Efficiency of Leaching versus Nonleaching Polymer Materials

Bruenke¹,

Roschke²,

Agarwal

et al. 2016

Macromolecular Bioscience

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New antimicrobial materials will be more and more in the focus for hygienic and clinical disease control. Antimicrobial materials have to be distinguished in leaching and nonleaching materials. For many applications of antimicrobial materials on implants the use of nonleaching materials is essential. Therefore, the antimicrobial efficiency of leaching and nonleaching polymers has been investigated quantitatively in vitro in direct comparison on a highly relevant implant of central venous catheters (CVCs) using a well‐established called Certika test. This test is especially designed to test antimicrobial properties of leachable and nonleachable materials. This contribution demonstrates that newly developed nonleaching antimicrobial CVCs are equivalent to conventional leaching CVC systems in their antimicrobial performance against gram‐positive and gram‐negative bacteria, as well as Candida species. The use of new nonleaching antimicrobial polymers as shown here for CVCs represents a different mode of action with the aim to prevent infections also with antibiotic‐resistant strains and reduced side effects.

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“…The duration of topical antiseptic treatment is usually 2-5 days, and in general should not exceed 14-21 days [51,52] . If the signs of infection do not recede, the efficacy of the measures used must be checked, and if necessary new measures must be initiated.…”

Section: Duration Of Treatment and Endpoint Of Antiseptic Therapy Andmentioning

confidence: 99%

Clinical Use of Polihexanide on Acute and Chronic Wounds for Antisepsis and Decontamination

Eberlein¹,

Assadian

2010

Skin Pharmacol Physiol

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Polihexanide is an antimicrobial compound suitable for clinical use in critically colonized or infected acute and chronic wounds. Its beneficial characteristic is attributable particularly to its broad antimicrobial spectrum, good cell and tissue tolerability, ability to bind to the organic matrix, low risk of contact sensitization, and wound healing promoting effect. In addition, no development of microorganism resistance during polihexanide use has been detected to date, nor does this risk appear imminent. The aim of therapy using polihexanide is to reduce the pathogen burden in a critically colonized or infected acute or chronic wound. An increasing number of articles on the subject of wound antisepsis with polihexanide can be found in the medical literature. However, there is still little published information on the practical use of polihexanide-containing wound antiseptics. The purpose of this review article is to describe the handling and the different possibilities of use of polihexanide-containing preparations, including the currently approved indications, contraindications and reservations. The use of polihexanide is not the only therapeutic option in management of wounds; therefore, priority is also given to prior surgical debridement and clarification of the cause of the underlying disease, including appropriate therapy.

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A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polihexanide

Cited by 51 publications

References 9 publications

Polihexanide for Wound Treatment – How It Began

Polihexanide for Wound Treatment – How It Began

Quantitative Comparison of the Antimicrobial Efficiency of Leaching versus Nonleaching Polymer Materials

Clinical Use of Polihexanide on Acute and Chronic Wounds for Antisepsis and Decontamination

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