Diclofenac Sodium (Voltaren) And Indomethacin in the Ambulatory Treatment of Rheumatoid Arthritis: A Double-Blind Multicentre Study

Mutru, O.; Penttilä, Matti; Pesonen, Janne; Salmela, Pasi; Suhonen, Olli; Sonck, T

doi:10.3109/03009747809097217

Cited by 21 publications

(4 citation statements)

References 9 publications

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“…Since indomethacin is a potent NSAID, it exerts its anti-inflammatory effect through the inhibition of prostaglandins that effectively suppress the inflammatory symptoms in arthritic joints. However, it delivers symptomatic relief, that is, pain and swelling in RA patients but cannot preclude joint destruction [50]. In contrast to indomethacin, NHAG-treated arthritic animals revealed mild increase synovial infiltration with slight bone and periarticular cartilage destruction.…”

Section: Discussionmentioning

confidence: 99%

The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis

Shah

Jawed

Awan

et al. 2013

BioMed Research International

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Rheumatoid arthritis (RA) is potentially devastating condition which lacks good treatment options. Pro-inflammatory cytokines interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and oxidative stress markers such as nitric oxide (NO) and peroxide (PO) are mediators of RA pathogenesis. In the present study N-[2,4,5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-3-yl]acrylamide (NHAG), analogue of glucosamine, was evaluated in adjuvant-induced arthritic model of rats. The disease progression was monitored by analysing arthritis scoring, loss of body weight, paw oedema, and histological changes in joints. RA associated hyperalgesia was evaluated by gait analysis. The serum or plasma levels of NO, PO, glutathione (GSH) superoxide dismutase (SOD) IL-1β and TNF-α were analyzed to monitor the state of disease severity. The arthritic control animals exhibited significant increase in arthritic score (P < 0.003) and paw oedema (P < 0.001) with parallel loss in body weight (P < 0.04). The NHAG-treated arthritic animals exhibited refinement in the gait changes associated with arthritis. NHAG also significantly decreased the NO (P < 0.02) and PO (P < 0.03) with concurrent increased in GSH (P < 0.04) and SOD (P < 0.007). Both IL-1β (P < 0.001) and TNF-α (P < 0.001), were significantly decreased in NHAG-treated group. Thus NHAG might have a therapeutic potential for arthritis by exerting antioxidative and immunomodulatory effects.

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Section: Discussionmentioning

confidence: 99%

The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis

Shah

Jawed

Awan

et al. 2013

BioMed Research International

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“…Diclofenac is a non-steroidal anti-inflammatory drug that regulates the inflammatory response in the active stage of RA. However, it is difficult to eliminate the cause of the induced inflammation[ 16 ]. Diprospans are widely used in RA.…”

Section: Discussionmentioning

confidence: 99%

Changes in rheumatoid arthritis under ultrasound before and after sinomenine injection

Huang¹,

Yu²,

Tan³

2022

WJCC

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BACKGROUND Rheumatoid arthritis (RA) is a prevalent clinical autoimmune disease that is commonly treated with diclofenac and methotrexate. In recent years, the application of traditional Chinese medicine in RA has received widespread attention; it promotes blood circulation, strengthens the immune system, and eliminates evil. The sinomenine preparation of Zhingqeng Fengtongning is studied as a possible treatment for patients with RA. AIM To explore the value of sinomenine injection into the articular cavity for the treatment of RA. METHODS A total of 94 patients with RA treated from January 2019 to January 2021 were selected and divided into the study and control groups with 47 patients each using a simple random number table method. Both groups received conventional treatment with diclofenac sodium and methotrexate tablets. The control group received diproxone and lidocaine by intra-articular administration while the study group received an intra-articular administration of the sinomenine preparation of Zhengqing Fengning and lidocaine. χ 2 test was used to evaluate the therapeutic effect and synovial thickness, degree of pain through the visual analog scale (VAS), blood flow grade, arthroinflammatory indexes [rheumatoid factor (RF), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR)] before and after treatment in the two groups. RESULTS The total effective rate of the study group (93.62%) was higher than that of the control group (78.72%) ( P < 0.05). Before treatment, there were no significant differences between the two groups in terms of synovial thickness, VAS score, blood flow grading, levels of RF, and ESR ( P > 0.05). After treatment, the synovial thickness and VAS score were significantly lower ( P < 0.05) in the study group than in the control group (2.05 ± 0.59 mm vs 2.87 ± 0.64 mm and 2.11 ± 0.62 vs 2.90 ± 0.79 scores, respectively). The rate of blood flow at grade 0 in the study group (76.60%) was higher than that in the control group (57.45%), and the rate of blood flow at grade I (10.64%) was lower than that in the control group (31.91%) ( P < 0.05). Furthermore, the levels of RF (55.61 ± 6.13 U/mL), CRP (11.43 ± 3.59 mg/L), and ESR (29.60 ± 5.56 mm/h) in the study group were lower than those in the control group (73.04 ± 9.23 U/mL, 15.07 ± 4.06 mg/L, 36.64 ± 6.10 mm/h, respectively) ( P < 0.05). CONCLUSION Sinomenine administration of Zhengqing Fengtongning in the articular cavity with conventional treatment of RA can improve ultrasonographic blood flow and synovial thickness, reduce pain, regulate inflammation, and enhance therapeutic effect.

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“…При назначении диклофенака натрия больным с хроническим артритом отмечалось значительное уменьшение выраженности артралгий, утренней скованности, припухлости суставов и болезненности при пальпации [43]. У пациентов с поражением околосуставных мягких тканей (субакромиальным бурситом, тендинитом вращательной манжетки, эпикондилитом) диклофенак натрия обеспечивал существенное снижение интенсивности болевого синдрома, а также значи-тельную положительную динамику функционального статуса [44][45][46].…”

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Pain in Rheumatoid Arthritis: Specific Features of Its Development and Methods of Correction

Олюнин¹

2010

Modern Rheumatology Journal

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Хронический воспалительный процесс у больных ревматоидным артритом (РА) сопровождается различными проявлениями, к числу которых относятся такие характерные и прогностически значимые признаки, как припухлость и деструктивные изменения суставов, функциональные нарушения, повышение уровня острофазовых показателей, ревматоидного фактора и антител к циклическому цитруллинированному пептиду. Однако центральное место в клинической картине заболевания, безусловно, занимает боль. Именно она является основной причиной, заставляющей пациента обращаться за медицинской помощью [1].За последнее время качество лечения больных РА существенно улучшилось, что способствовало уменьшению тяжести заболевания в целом. Однако боль по-прежнему остается серьезной проблемой. При сопоставлении статуса больных РА, наблюдавшихся в разное время в одной и той же клинике, было установлено, что у обследованных в 2000 г. отмечались достоверно более благоприятные показатели суставного счета, рентгенологического и лабораторного исследования, а также функционального статуса, чем у тех, кто был обследован в 1985 г. Однако интенсивность боли не уменьшилась [2].

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Diclofenac Sodium (Voltaren) And Indomethacin in the Ambulatory Treatment of Rheumatoid Arthritis: A Double-Blind Multicentre Study

Cited by 21 publications

References 9 publications

The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis

The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis

Changes in rheumatoid arthritis under ultrasound before and after sinomenine injection

Pain in Rheumatoid Arthritis: Specific Features of Its Development and Methods of Correction

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