Diclofenac release from alginate/carboxymethyl cellulose mono and bilayer films for wound dressing applications

Trevisol, Thalles Canton; Scartazzini, Laura; Valério, Alexsandra; Souza, Selene M.A. Guelli U. de; Bierhalz, Andréa Cristiane Krause; Valle, José Alexandre Borges

doi:10.1007/s10570-020-03217-3

Cited by 21 publications

(14 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with previously reported studies about bilayer films, where contents of the secondary layer affected the release of actives from the primary layer. 67 , 68 …”

Section: Resultsmentioning

confidence: 99%

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

Khan

et al. 2021

DDDT

View full text Add to dashboard Cite

Background/Objective: Periodontitis is a widely spread oral infection and various antibiotics are utilized for its treatment, but high oral doses and development of antibiotic resistance limit their use. This study was aimed at development of natural polymer-based mucoadhesive bilayer films loaded with moxifloxacin hydrochloride (Mox) and clove essential oil (CEO) to potentially combat bacterial infection associated with periodontitis. Methods: Films were synthesized by double solvent casting technique having an antibiotic in the gellan gum-based primary layer with clove oil in a hydroxyethyl cellulose-based secondary layer. Results: Prepared films were transparent, flexible, and showed high antibacterial response against both gram-positive and gram-negative bacteria. The films showed excellent pharmaceutical attributes in terms of drug content, folding endurance, swelling index, and mucoadhesive strength. Solid state characterization of formulation showed successful incorporation of drug and oil in separate layers of hydrogel structure. An in-vitro release study showed an initial burst release of drug followed by sustained release for up to 48 hours. Conclusion:The prepared mucoadhesive bilayer buccal films could be used as a potential therapeutic option for the management of periodontitis.

show abstract

“…This is in agreement with previously reported studies about bilayer films, where contents of the secondary layer affected the release of actives from the primary layer. 67 , 68 …”

Section: Resultsmentioning

confidence: 99%

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

Khan

et al. 2021

DDDT

View full text Add to dashboard Cite

show abstract

“…In recent years, significant progress has been made in the field of biology, medicine and materials science, which has led to the development of innovative systems, including films, hydrogels and micro-and nanoparticulate systems based on natural/synthetic polymers as drug carriers. The advantages of such drug delivery systems are the improved therapeutic efficacy of drugs and reduced side effects and associated costs [1][2][3]. Generally, polymeric films are biocompatible and can be used as supports for the controlled release of bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

“…The content in the residues of D-manuronate and α-L-guluronate alginates and the length of each block may differ depending on the species of algae used for their extraction. Alginates are excellent candidates for the development of different systems, such as films, membranes, hydrogels, particles and nanofibers [1,4,6].…”

Section: Introductionmentioning

confidence: 99%

Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study

et al. 2021

View full text Add to dashboard Cite

New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amounts of water). The characterization of their structural, morphological, swelling capacity, loading/release and drug efficiency traits proved that these new hydrogels are promising materials for controlled drug delivery systems. Further, a new theoretical model, in the framework of Scale Relativity Theory, was built with to offer insights on the release process at the microscopic level and to simplify the analysis of the release process.

show abstract

“…In literature, there are wound dressing studies focus on different aspects such as drug release from Ca 2+ crosslinked [11] and layer-by-layer coated [12] Alg/CMC films, the effect of polymer ratio for Ca 2+ crosslinked Alg/CMC film [13], silver nanoparticle containing antimicrobial Alg/gelatin/CMC fabric [14]. However, a wound dressing film containing only cerium crosslinked Alg/CMC and that is antimicrobial has not been reported.…”

mentioning

confidence: 99%

A Potential Antibacterial Wound Dressing Based on Cerium Crosslinked Alginate and Carboxymethyl Cellulose

Abtahi

Orhan

Vatansever

et al. 2022

Preprint

View full text Add to dashboard Cite

Recently, biopolymer based wound dressing films were studied due to their biocompatibility and biodegradability. In this study, a film was prepared with alginate (Alg) and carboxymethyl cellulose (CMC) by crosslinking with Ce3+ ion to evaluate the antibacterial properties of the film. The film exhibits antibacterial activity against Gram positive (Staphylococcus aureus) and Gram negative (Escherichia coli) bacteria. Physical and chemical characterizations of the film were assessed through FT-IR spectrometry, SEM, swelling, water vapor transmission (WVT), and ultraviolet-visible light transmittance tests. The chemical and physical attributes of the film prove to be potentially advantageous for wound dressings due to its UV-protective, vapor permeable, swellable and antimicrobial properties.

show abstract

Diclofenac release from alginate/carboxymethyl cellulose mono and bilayer films for wound dressing applications

Cited by 21 publications

References 60 publications

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis

Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study

A Potential Antibacterial Wound Dressing Based on Cerium Crosslinked Alginate and Carboxymethyl Cellulose

Contact Info

Product

Resources

About