Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study

Peptu, Cătălina Anişoara; Băcăiță, Elena Simona; Savin, Corina-Lenuta; Luțcanu, Marian; Agop, Maricel

doi:10.3390/polym13244461

Cited by 7 publications

(11 citation statements)

References 27 publications

(34 reference statements)

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“…In line with previous research, Peptu et al [ 80 ] synthesized alginate (AG)/CMCNa-based hydrogel with ECH as a crosslinking agent. It was found that high superabsorbent properties, indicated by a maximum swelling ratio of 1273%, were observed for the sample with 1:1 AG:CMC molar ratio, 6.6% polymer concentration, and 0.75 mL of ECH.…”

Section: Types Of Crosslinking Agents In the Synthesis Of Cellulose-b...supporting

confidence: 59%

Hydrogel and Effects of Crosslinking Agent on Cellulose-Based Hydrogels: A Review

Nasution

Harahap

Dalimunthe

et al. 2022

Gels

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Hydrogels are hydrophilic polymer materials that can swell but are insoluble in water. Hydrogels can be synthesized with synthetic or natural polymers, but natural polymers are preferred because they are similar to natural tissues, which can absorb a high water content, are biocompatible, and are biodegradable. The three-dimensional structure of the hydrogel affects its water insolubility and ability to maintain its shape. Cellulose hydrogels are preferred over other polymers because they are highly biocompatible, easily accessible, and affordable. Carboxymethyl cellulose sodium (CMCNa) is an example of a water-soluble cellulose derivative that can be synthesized using natural materials. A crosslinking agent is used to strengthen the properties of the hydrogel. Chemical crosslinking agent is used more often than physical crosslinking agent. In this review, article, different types of crosslinking agents are discussed based on synthetic and natural crosslinking agents. Hydrogels that utilize synthetic crosslinking agent have advantages, such as adjustable mechanical properties and easy control of the chemical composition. However, hydrogels that use natural crosslinking agent have better biocompatibility and less latent toxic effect.

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Section: Types Of Crosslinking Agents In the Synthesis Of Cellulose-b...supporting

confidence: 59%

Hydrogel and Effects of Crosslinking Agent on Cellulose-Based Hydrogels: A Review

Nasution

Harahap

Dalimunthe

et al. 2022

Gels

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“…Thus, if the hydrodynamic scenario allows the “decoding” of some drug release mechanisms, then the Schrodinger scenario can be employed for the “plotting” of the drug release curves. For a better understanding of our argumentation, let us remind the hypotheses from (Peptu et al, 2021 ): the dynamics of any complex system, independent of the two scale resolutions (differentiable and non-differentiable scale resolutions), are one-dimensional dynamics; the synchronization of the dynamics of any complex system at the two scale resolutions is achieved by “compensating” the velocity fields and given by the restriction ; the polymer network operates by means of a potential vector (for details, see (Peptu et al, 2021 )). …”

Section: Resultsmentioning

confidence: 99%

“…The functionality of such a hypothesis implies, based on the Scale Relativity Theory, employing, in the description of polymer-drug dynamics, continuous and non-differential curves (fractal/multifractal curves). Then, two scenarios for describing polymer-drug dynamics become compatible: release dynamics in the Schrödinger multifractal scenario (multifractal Schrödinger equation) (Peptu et al, 2021 ): release dynamics in the Madelung multifractal scenario (multifractal hydrodynamic equation) (Peptu et al, 2021 ): where denotes the multifractal specific potential: …”

Section: Methodsmentioning

confidence: 99%

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Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles

et al. 2022

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The physicochemical properties of “smart” or stimuli-sensitive amphiphilic copolymers can be modeled as a function of their environment. In special, pH-sensitive copolymers have practical applications in the biomedical field as drug delivery systems. Interactions between the structural units of any polymer-drug system imply mutual constraints at various scale resolutions and the nonlinearity is accepted as one of the most fundamental properties. The release kinetics, as a function of pH, of a model active principle, i.e., Curcumin, from nanomicelles obtained from amphiphilic pH-sensitive poly(2-vinylpyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) tailor-made diblock copolymers was firstly studied by using the Rietger-Peppas equation. The value of the exponential coefficient, n, is around 0.5, generally suggesting a diffusion process, slightly disturbed in some cases. Moreover, the evaluation of the polymer-drug system’s nonstationary dynamics was caried out through harmonic mapping from the usual space to the hyperbolic one. The kinetic model we developed, based on fractal theory, fits very well with the experimental data obtained for the release of Curcumin from the amphiphilic copolymer micelles in which it was encapsulated. This model is a variant of the classical kinetic models based on the formal kinetics of the process.

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“…Drug delivery vector is one of the most common applications of CMC gels owing to their good drug loading and drug release ability [ 43 , 44 , 45 , 46 , 47 ]. Zhang et al designed a type of CMC gel, CMC-polydopamine-NaI (CDI) hydrogel, with the anti-tumor abilities of photothermal therapy (PTT) and photodynamic therapy (PDT) after loading polydopamine (PDA) and Chlorin e6 (Ce6) [ 48 ].…”

Section: Applicationsmentioning

confidence: 99%

Synthesis and Applications of Carboxymethyl Cellulose Hydrogels

Zhang

Liu

et al. 2022

Gels

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Hydrogels are basic materials widely used in various fields, especially in biological engineering and medical imaging. Hydrogels consist of a hydrophilic three-dimensional polymer network that rapidly expands in water and can hold a large volume of water in its swelling state without dissolving. These characteristics have rendered hydrogels the material of choice in drug delivery applications. In particular, carboxymethyl cellulose (CMC) hydrogels have attracted considerable research attention for the development of safe drug delivery carriers because of their non-toxicity, good biodegradability, good biocompatibility and low immunogenicity. Aiming to inspire future research in this field, this review focuses on the current preparation methods and applications of CMC gels and highlights future lines of research for the further development of diverse applications.

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Hydrogels Based on Alginates and Carboxymethyl Cellulose with Modulated Drug Release—An Experimental and Theoretical Study

Cited by 7 publications

References 27 publications

Hydrogel and Effects of Crosslinking Agent on Cellulose-Based Hydrogels: A Review

Hydrogel and Effects of Crosslinking Agent on Cellulose-Based Hydrogels: A Review

Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles

Synthesis and Applications of Carboxymethyl Cellulose Hydrogels

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