Diazoxide for the treatment of hypoglycaemic dumping syndrome

Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment

“…In the beta cells of the pancreas, open potassium channels maintain a polarized state which inhibits the secretion of insulin. Thus, diazoxide has showed success in recent studies in treating late dumping hypoglycemia and can be used when acarbose and lifestyle modifications are insufficient [42,43].…”

Safety and efficacy of pasireotide in dumping syndrome—results from a phase 2, multicentre study

“…Currently, there is no approved medical treatment available for patients with dumping syndrome . Use of acarbose and diazoxide in some patients have been reported to improve late dumping symptoms. Octreotide, a first‐generation somatostatin analogue approved for use in acromegaly and gastroenteropancreatic neuroendocrine tumours, administered either as subcutaneous (SC) or as intramuscular (IM) long‐acting injection, has been used off‐label for the treatment of patients with dumping syndrome in whom first‐line measures fail .…”

Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy

“…Successful treatment of post-gastrectomy hypoglycemia by diazoxide, a K ATP channel opener, has actually been reported [10,11]. In the present patient, however, diazoxide failed to improve the hyperinsulinemia.…”

“…ide, and also pancreatectomy, have been applied for the management of postprandial hypoglycemia after gastrectomy [5][6][7][8][9][10][11][12]. However, adverse effects of the drugs and complications of the surgery pose limitations, and no standard treatment for postprandial hypoglycemia has been established yet.…”