Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy

Shirakawa, Jun; Murohashi, Yuko; Okazaki, Naoaki; Yamazaki, Shunsuke; Tamura, Tetsuya; Okuyama, Tomoko; Togashi, Yuichi; Terauchi, Yasuo

doi:10.1507/endocrj.ej14-0290

Cited by 3 publications

(1 citation statement)

References 36 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One potential advantage of hypoglycemic drug based on glycosidase inhibitors is that they may carry a reduced risk of hypoglycemia, which is related to the hypoglycemic mechanism. α-Glucosidase inhibitors can efficiently inhibit disaccharide-hydrolyzing glycosidase in the intestine, and suppress postprandial elevation of plasma glucose by delaying the digestion and absorption of carbohydrates, which are less likely to lead to the hypoglycemia. − Given the extended binding interaction between multivalent glucosidase inhibitor LP-4DNJ-6C assemblies and α-glucosidase observed in the small intestine of mice, further investigation is necessary to determine its potential for both hypoglycemic risk and long-term efficacy as a therapeutic agent.…”

Section: Resultsmentioning

confidence: 99%

Amphiphilic α-Peptoid-deoxynojirimycin Conjugate-based Multivalent Glycosidase Inhibitor for Hypoglycemic Effect and Fluorescence Imaging

Wang,

Yan,

Rong

et al. 2024

J. Med. Chem.

View full text Add to dashboard Cite

Multivalent glycosidase inhibitors based on 1-deoxynojirimycin derivatives against α-glucosidases have been rapidly developed. Nonetheless, the mechanism based on self-assembled multivalent glucosidase inhibitors in living systems needs to be further studied. It remains to be determined whether the self-assembly possesses sufficient stability to endure transit through the small intestine and subsequently bind to the glycosidases located therein. In this paper, two amphiphilic compounds, 1-deoxynojirimycin and α-peptoid conjugates (LP-4DNJ-3C and LP-4DNJ-6C), were designed. Their self-assembling behaviors, multivalent α-glucosidase inhibition effect, and fluorescence imaging on living organs were studied. LP-4DNJ-6C exhibited better multivalent α-glucosidase inhibition activities in vitro. Moreover, the self-assembly of LP-4DNJ-6C could effectively form a complex with Nile red. The complex showed fluorescence quenching effect upon binding with α-glucosidases and exhibited potent fluorescence imaging in the small intestine. This result suggests that a multivalent hypoglycemic effect achieved through self-assembly in the intestine is a viable approach, enabling the rational design of multivalent hypoglycemic drugs.

show abstract

Section: Resultsmentioning

confidence: 99%