Amphiphilic α-Peptoid-deoxynojirimycin Conjugate-based Multivalent Glycosidase Inhibitor for Hypoglycemic Effect and Fluorescence Imaging
Guang-Yuan Wang,
Dong-Xiao Yan,
Rui-Xue Rong
et al.
Abstract:Multivalent
glycosidase inhibitors based on 1-deoxynojirimycin
derivatives against α-glucosidases have been rapidly developed.
Nonetheless, the mechanism based on self-assembled multivalent glucosidase
inhibitors in living systems needs to be further studied. It remains
to be determined whether the self-assembly possesses sufficient stability
to endure transit through the small intestine and subsequently bind
to the glycosidases located therein. In this paper, two amphiphilic
compounds, 1-deoxynojirimycin and … Show more
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