Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum

Guilarte, Mar; Santos, Javier; Torres, Inés de; Alonso, Carmen; Vicario, María; Ramos, Laura; Martínez, Cristina; Casellas, Francesc; Saperas, Esteban; Malagelada, Juan R.

doi:10.1136/gut.2006.100594

Cited by 339 publications

(307 citation statements)

References 59 publications

(47 reference statements)

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“…Recently, the role of microscopic inflammation and immune activation in the intestinal mucosa has been elucidated. 3,5,22 Gastrointestinal infections are more likely to initiate IBS-like symptoms 23 inducing mucosal inflammation. Impaired intestinal permeability 24 and a role for mucosal inflammation in regulating the gut-brain axis 25 have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Carroccio

Brusca

Mansueto

et al. 2011

Clinical Gastroenterology and Hepatology

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Section: Discussionmentioning

confidence: 99%

Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Carroccio

Brusca

Mansueto

et al. 2011

Clinical Gastroenterology and Hepatology

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“…35 Alterations in the production of these pro-inflammatory cytokines (primarily produced by monocytes and macrophages) are suggestive of an increase in innate immune activity in IBS patients. Accordingly, data collected from D-IBS patients indicate an increase in protease activity in the stool 39 and jejunal fluid 40 and an increase in NO release in the rectal mucosa, 41 indicating the potential involvement of mast cells in the increased release of inflammatory mediators. This finding is consistent with data indicating an increase in blood levels of lipid inflammatory mediators such as prostaglandin E2 and leukotriene B4, which are known to be released from newly formed mast cells.…”

Section: Resultsmentioning

confidence: 99%

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

Matricon

Méleine

Gelot

et al. 2012

Aliment Pharmacol Ther

185

180

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This uncommissioned review article was subject to full peer-review. SUMMARY BackgroundIrritable bowel syndrome (IBS), one of the most common gastrointestinal disorders, markedly impairing patients' quality of life. Drug development for IBS treatment has been hampered by the lack of understanding of IBS aetiology. In recent years, numerous data have emerged that suggest the involvement of immune activation in IBS, at least in a subset of patients. AimTo determine whether immune activation and intestinal permeabilisation are more frequently observed in IBS patients compared with healthy controls. MethodsThe scientific bibliography was searched using the following keywords: irritable bowel syndrome, inflammation, immune activation, permeabilisation, intestine, assay, histology and human. The retrieved studies, including blood, faecal and histological studies, were analysed to provide a comprehensive and structured overview of the available data including the type of assay, type of inflammatory marker investigated or intestinal segment studied. ResultsImmune activation was more frequently observed in IBS patients than in healthy controls. An increase in the number of mast cells and lymphocytes, an alteration in cytokine levels and intestinal permeabilisation were reported in IBS patients. No consistent changes in the numbers of B cells or enterochromaffin cells or in mucosal serotonin production were demonstrated. ConclusionsThe changes observed were modest and often heterogeneous among the studied population. Only appropriate interventions improving irritable bowel syndrome symptoms could highlight and confirm the role of immune activation in this pathophysiology.

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“…32,33 Previous studies also show an increase in T lymphocyte infiltrates. 12,14,25,29,30,33 Conversely, there appears to be no significant differences in tissue eosinophil counts of patients with IBS. 12,14,31,34 However, histopathological studies in pediatric patients with AP-FGID are relatively scarce, moreover, the results of some studies are discrepant from those of studies on adults.…”

Section: Introductionmentioning

confidence: 88%

“…13,[16][17][18][19][20][21] On the other hand, several studies also show increased infiltration and degranulation of gastric and duodenal mast cells in adult FD patients. 16,[22][23][24] In adult patients with IBS, most studies demonstrate increased infiltration of mast cells in all parts of the duodenum, 14 jejunum, 25 ileum, 26 and colon, 12,[27][28][29][30][31] with the exception of a few studies. 32,33 Previous studies also show an increase in T lymphocyte infiltrates.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Gastric and Duodenal Eosinophils in Children with Abdominal Pain Related Functional Gastrointestinal Disorders According to Rome III Criteria

Lee

Yang

Lee

2016

J Neurogastroenterol Motil

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Background/AimsAbdominal pain-related functional gastrointestinal disorder (AP-FGID) is common in children and adults. However, the mechanism of AP-FGID is not clearly known. Recently, micro-inflammation, especially eosinophilia in the gastrointestinal tract, was suggested in the pathophysiology of AP-FGID in adults. The aim of this study was to evaluate the association of gastric and duodenal eosinophilia with pediatric AP-FGID. MethodsIn total, 105 pediatric patients with AP-FGID were recruited and classified into 4 subgroups based on the Rome III criteria. Eosinophil counts in the gastric and duodenal tissues of children with AP-FGID were compared to those from normal pathology references or those of children with Helicobacter pylori infection. Tissue eosinophil counts were also compared among the 4 subtypes of AP-FGID. ResultsEosinophil counts in the gastric antrum and body were significantly higher in children with AP-FGID than normal reference values. Duodenal eosinophil counts were higher in children with AP-FGID, but not significantly when compared with normal reference values. There were no significant differences in eosinophil counts of the stomach or duodenum among the 4 subtypes of AP-FGID. Eosinophils counts in the gastric antrum and body were significantly higher in children with H. pylori infection than in those with AP-FGID. Duodenal eosinophilia was prominent in cases of H. pylori infection, but not statistically significant when compared with AP-FGID. ConclusionsOur study revealed that gastric eosinophilia is associated with AP-FGID in children, regardless of the subtype of functional abdominal pain. This suggests some contribution of gastrointestinal eosinophils in the development of pediatric AP-FGID.

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Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum

Cited by 339 publications

References 59 publications

Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Fecal Assays Detect Hypersensitivity to Cow's Milk Protein and Gluten in Adults With Irritable Bowel Syndrome

Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome

Analysis of Gastric and Duodenal Eosinophils in Children with Abdominal Pain Related Functional Gastrointestinal Disorders According to Rome III Criteria

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