Diamox

Merlis, Sidney

doi:10.1212/wnl.4.11.863

Cited by 36 publications

(11 citation statements)

References 0 publications

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“…Eight of the patients we studied, however, all of whom showed a most satisfactory response and then returned to their previous state in about two months, did not improve when the dosage was increased to as much as 20 mg. per kg. The observation of Lombroso et al (1956) and of Merlis (1954), that patients showing enhancement of their E.E.G. abnormalities with overbreathing are more likely to respond to acetazolamide, was not confirmed in this study.…”

Section: Disculsioncontrasting

confidence: 71%

“…Recently a much more potent carbonic anhydrase inhibitor-acetazolamide ('diamox ") -has been introduced, and it seemed reasonable to attempt an evaluation of its anticonvulsant properties in view of its ability to produce an acidosis. Bergstrom et al (1952), Merlis (1954), Pero (1955), Vivien (1955), Ferroni et al (1955), Munoz and Gomensoro (to be published), and Lombroso et al (1956) have already reported its effects in epilepsy, and the present study is a further attempt to assess its value.…”

Section: Resultsmentioning

confidence: 59%

“…Further support has One patient been given by Lombroso et al (1956) and Ferroni et al that ln minor (1955). The patients treated by Merlis (1954) had assolueless, but it ciated psychiatric disorders, and again assessment is not ittacks in the easy, although this author also described the beneficial effect of acetazolamide in many cases. No serious side-effects have been reported by any workers.…”

Section: Disculsionmentioning

confidence: 91%

“…The dose used at the onset of this investigation was small an adjuvant compared with that of other authors (Merlis, 1954). Howhen occurred ever, 125 mg. twice daily having been shown to have an jence in only adequate pharmacological effect in the form of a systemic acidosis (Counihan et al, 1954), it was decided to begin :n cases the with this.…”

Section: Disculsionmentioning

confidence: 95%

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Acetazolamide in Treatment of Epilepsy

Ansell¹,

Clarke²

1956

BMJ

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Section: Disculsioncontrasting

confidence: 71%

Section: Resultsmentioning

confidence: 59%

Section: Disculsionmentioning

confidence: 91%

Section: Disculsionmentioning

confidence: 95%

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Acetazolamide in Treatment of Epilepsy

Ansell¹,

Clarke²

1956

BMJ

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“…This was first reported by Merlis in the abstracts of the American League Against Epilepsy meeting in 1954 ( [77] Fig. 8).…”

Section: Acetazolamide (Diamox)mentioning

confidence: 61%

The Treatment of Epilepsy

Shorvon¹,

Perucca²,

Engel³

2004

118

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Influence of Acetazolamide on Cerebral Blood Flow

Ehrenreich¹,

Burns²,

Alman³

et al. 1961

Archives of Neurology

114

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Carbonic anhydrase inhibitors have been used in clinical medicine as diuretics,1-3 as anticonvulsants,4,5 to reduce intraocular tension,6,7 to lower intracranial pressure,8,9 and in the treatment of respiratory insufficiency.10,11 In the course of investigation of the effects of acetazolamide in hepatic encephalopathy, Posner and Plum 12 observed without comment a considerable increase in rate of cerebral blood flow after intravenous administration of 1 to 2 gm. of acetazolamide. Such a cerebral circulatory change had previously been considered to account for the brief elevation of cerebrospinal fluid pressure after intravenous acetazolamide.9,13In view of these findings, we felt that the usefulness of carbonic anhydrase inhibitors might be extended to the management of patients with intermittent cerebral vascular insufficiency. In this preliminary report, observations of the quantitative cerebral hemodynamic effects of intravenous acetazolamide are presented. In several subjects, the effects of inhalation of 5% CO2 were also noted for comparative purposes. MethodThe subjects of this investigation were 10 pa¬ tients hospitalized for clinical study of cerebral vascular disease believed to be the cause of cir¬ culatory insufficiency of internal carotid or vertebral-basilar artery systems. In all cases, the disorder was manifested by recurrent, transitory neurological dysfunction, considered on clinical grounds to involve the cerebral areas primarily supplied by the arterial systems noted, and assumed to be due to intermittent ischemia of these areas.Cerebral hemodynamic studies were performed before and 30 to 60 minutes after the intravenous administration of 1 gm. of acetazolamide (2 gm. in one instance) over a 10-minute period. In 8 of these patients, the effects of inhalation of S'%

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Diamox

Cited by 36 publications

References 0 publications

Acetazolamide in Treatment of Epilepsy

Acetazolamide in Treatment of Epilepsy

The Treatment of Epilepsy

Influence of Acetazolamide on Cerebral Blood Flow

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